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Chronic Pain clinical trials
Every US clinical trial registered for Chronic Pain — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
302 US clinical trials · 139 currently recruiting
The research picture
Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now — about 46% of the total.
- 139
- recruiting participants now
- 46%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 16
- top sponsor: VA Office of Research and Development
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
RIVER At Home Ketamine Protocols
RIVER Foundation
NCT06070766
A DirEct to PatieNt Study in Chronic Pain
Boston Scientific Corporation
NCT05515341
Patient Retrospective Outcomes (PRO)
Boston Scientific Corporation
NCT01550575
A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children
Telethon Kids Institute
NCT06354699
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Abbott Medical Devices
NCT03876054
Impact of 4PCP on Practitioner and Patient Outcomes
Virginia Commonwealth University
NCT05580419
Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
Washington University School of Medicine
NCT06978166
Embo Registry; National Registry for Artery Embolization
Vascular Solutions of North Carolina
NCT06477965
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
Chronic Pain Management In Primary Care Using Behavioral Health Consultants
The University of Texas Health Science Center at San Antonio
NCT04680000
Tele-Collaborative Outreach to Rural Patients With Chronic Pain
Oregon Health and Science University
NCT06091202
Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity
University of California, San Francis
NCT06183281
AIMS Medical Outcomes Study
Advanced Integrative Medical Science Institute
NCT04512755
Targeted Realtime Assessment of Chronic Pain in Youth
Stanford University
NCT06867757
Nonpharmacologic Pain Management in FQHC Primary Care Clinics
University of Utah
NCT04923334
Ketamine Treatment Plans for Chronic Conditions
RIVER Foundation
NCT06038409
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Anna Evans Phillips
NCT03434392
MIVetsCan: Can-Coach Trial (Phase 2)
University of Michigan
NCT06283862
Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain
Rush University Medical Center
NCT06044649
Stanford Pragmatic Effectiveness Comparison
Stanford University
NCT04441034
Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial
VA Office of Research and Development
NCT07149870
Overlapping Pain Trajectory Study
Children's Hospital Medical Center, Cincinnati
NCT05752396
Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention
Florida State University
NCT07335159
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
Massachusetts General Hospital
NCT06246929
Telehealth for Pain and Unhealthy Drinking Among PLWH
Boston University
NCT05503173
Partners4Pain & Wellbeing: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain
University of Minnesota
NCT06696352
CARES-Spine (Comprehensive Analgesic, Recovery, and Education Support for Spine Surgery) Trial
Stanford University
NCT06027099
Group-based Integrative Pain Management in Primary Care Safety Net Clinics
University of California, San Francis
NCT06327542
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Rush University Medical Center
NCT05700279
HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
Rhode Island Hospital
NCT06931158
Equipping Patients Using Interventions for Pain and Depression
Indiana University
NCT06500780
Under-Resourced Adults With Chronic Pain eHealth Study
Mayo Clinic
NCT06688864
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Hugo W. Moser Research Institute at Kennedy Krieger
NCT05197946
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
University of Utah
NCT06387290
Individual Differences in Gait and Osteoarthritis Pain
University of Pittsburgh
NCT07308873
Better Options for Chronic Cancer Pain
VA Office of Research and Development
NCT06574009
Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain
Palo Alto Veterans Institute for Research
NCT06704061
Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain
VA Office of Research and Development
NCT06058624
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
Medical University of South Carolina
NCT06442566
EPPIC: Easing Pelvic Pain Interventions Clinical Research Program
State University of New York at Buffalo
NCT05127616
Examining Racial and Socioeconomic Differences in Chronic Low Back Pain
Washington University School of Medicine
NCT05991440
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial
St. Jude Children's Research Hospital
NCT07160621
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
University of New Mexi
NCT06565416
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)
Evon Medics
NCT06671132
Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain
Cambridge Health Alliance
NCT06515925
Stepped Care for Patients to Optimize Whole Recovery
Yale University
NCT05155163
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
University of Pittsburgh
NCT06855732
A Mobile Intervention to Reduce Pain and Improve Health-III
Wake Forest University
NCT06623669
Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)
CognifiSense
NCT07033195
Improving Health for Older Adults With Pain Through Engagement
Massachusetts General Hospital
NCT06119698
Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain
Washington University School of Medicine
NCT07270406
Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
University of Florida
NCT05561595
CBT-CP for Veterans With SMI
VA Office of Research and Development
NCT06758414
IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs
Albert Einstein College of Medicine
NCT05492825
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
Massachusetts General Hospital
NCT05661903
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
University of South Florida
NCT06345872
Randomized Trial of ACT and a Care Management App in Primary Care-based Buprenorphine Treatment
Albert Einstein College of Medicine
NCT05039554
RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain
VA Office of Research and Development
NCT05963607
Mind Body Syndrome Therapy for Chronic Pain
Beth Israel Deaconess Medical Center
NCT04689646
Divided or Single Exposure (DOSE) Study
University of Maryland, Baltimore
NCT05459402
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
University of Pittsburgh
NCT04996628
PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial
Salem Veterans Affairs Medical Center
NCT06427356
Combined THC and CBD for OUD and Chronic Pain
Yale University
NCT06544291
Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD
The University of Texas Health Science Center, Houston
NCT07116109
Neuroimaging of Opioid Phase (OPAL)
Duke University
NCT05905419
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Duke University
NCT06983678
Optimization of NIBS for Treatment of Addiction
Case Western Reserve University
NCT04379115
Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)
David Moss
NCT07094282
Utilizing Battlefield Acupuncture to Treat Chronic Pain
Edith Nourse Rogers Memorial Veterans Hospital
NCT06128772
Pain Reduction Using NEurostimulation Study
Weill Medical College of Cornell University
NCT05311956
The PROACTIVE Study for Black Elders
University of Florida
NCT06512727
VCOM Pain Free Research Collaborative
Edward Via Virginia College of Osteopathic Medicine
NCT06533345
Brief Mindfulness-Oriented Recovery Enhancement vs Brief Cognitive-Behavioral Therapy for Chronic Pain
Florida State University
NCT07207174
Placebo Impacts Sleep and Pain Modulation in Chronic Pain
University of Maryland, Baltimore
NCT06225817
Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain
Stanford University
NCT04546685
Can Medical Cannabis Affect Opioid Use?
Thomas Jefferson University
NCT06206252
Evaluating the Acceptability, Feasibility and Usability of Various Conversational Data Collection Software
AugMend Health
NCT07336537
Examining the Effectiveness of Asynchronous Versus Synchronous Yoga for Veterans With Chronic Pain
Portland VA Medical Center
NCT06973876
Improving Sleep in Veterans With the Polytrauma Clinical Triad
VA Office of Research and Development
NCT06477796
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
Spaulding Rehabilitation Hospital
NCT04206215
Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders
University of Minnesota
NCT05068908
NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow
The Cleveland Clinic
NCT06373978
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions
Navy Medical Center San Diego
NCT06273462
Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Florida State University
NCT06471075
A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults
University of Michigan
NCT06671925
Dronabinol as an Adjunct for Reducing Pain
Christopher D. Verri
NCT06454669
Pilot Study: Impact of Biomarker-Guided Dietary Supplementation on Quality-of-Life Measures in Subjects With Chronic Pain
Ethos Research & Development
NCT06247813
Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department
Western Michigan University School of Medicine
NCT06395428
Predictors of Pain in Sickle Cell Disease
Duke University
NCT06139510
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Boston Scientific Corporation
NCT07190807
Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty
Hospital for Special Surgery, New York
NCT05981105
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Duke University
NCT06747871
CIH Stepped Care for Co-occurring Chronic Pain and PTSD
University of Washington
NCT06219408
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
University of Iowa
NCT07032350
Group Integrative Breathwork for Chronic Pain
University of Florida
NCT06977984
Opioid Adherence and Support Through Innovative Texting Strategies
University of New Mexi
NCT07350148
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
Massachusetts General Hospital
NCT07118722
Comparing the Effects of Yoga Nidra to Yoga Nidra With Pain Acceptance Intention and Motor Imagery on Pain Outcomes
University of Central Florida
NCT06590181
Pain and Major Depressive Disorder
University of California, Los Angeles
NCT04556890
Using Ecological Momentary Assessment to Develop an Adaptive Psychological Intervention for Young Adults With Chronic Pain
Seattle Children's Hospital
NCT06932432
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Pain Trial Landscape
ClinicalTrials.gov lists 302 US studies indexed under Chronic Pain, and 139 of those are currently open to recruitment — roughly 46% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Chronic Pain shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 41 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Chronic Pain is led by VA Office of Research and Development with 16 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Pain?
PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.