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Chronic Pain: early-phase trial registry
139 of 302 indexed Chronic Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #29 of 28,707 conditions by registered trial count.
302 US clinical trials · 139 currently recruiting · #29 of 28,707 conditions by registered trial count
Chronic Pain: 302 US clinical trials tracked, 139 recruiting.
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition chronic-pain
OPEN 139 | RECR 46% | LATE 15 | EARLY 41 | RANK #29 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Recurrent Glioblastoma (46% recruiting · 63 trials)
Chronic Pain lists 139 open slots (46% of 302 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Pain is recruiting above its size-band peers.
139 of 302 indexed trials (46%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 302 trials (5.3%). 155 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Pain enrolment sits around 80 participants.
Median target enrolment is 80 among the 302 trials that report a genuine target (sentinel values excluded). 164 of those (54.3%) plan for fewer than 100 participants.
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Chronic Pain research is mostly interventional.
260 interventional and 42 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
302 total, page 1 of 7
RIVER At Home Ketamine Protocols
RIVER Foundation
NCT06070766
A DirEct to PatieNt Study in Chronic Pain
Boston Scientific Corporation
NCT05515341
Patient Retrospective Outcomes (PRO)
Boston Scientific Corporation
NCT01550575
A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children
Telethon Kids Institute
NCT06354699
Long-Term Real-World Outcomes Study on Patients Implanted With a Neurostimulator
Abbott Medical Devices
NCT03876054
Impact of 4PCP on Practitioner and Patient Outcomes
Virginia Commonwealth University
NCT05580419
Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
Washington University School of Medicine
NCT06978166
Embo Registry; National Registry for Artery Embolization
Vascular Solutions of North Carolina
NCT06477965
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
Chronic Pain Management In Primary Care Using Behavioral Health Consultants
The University of Texas Health Science Center at San Antonio
NCT04680000
Tele-Collaborative Outreach to Rural Patients With Chronic Pain
Oregon Health and Science University
NCT06091202
Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity
University of California, San Francisco
NCT06183281
AIMS Medical Outcomes Study
Advanced Integrative Medical Science Institute
NCT04512755
Targeted Realtime Assessment of Chronic Pain in Youth
Stanford University
NCT06867757
Nonpharmacologic Pain Management in FQHC Primary Care Clinics
University of Utah
NCT04923334
Ketamine Treatment Plans for Chronic Conditions
RIVER Foundation
NCT06038409
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Anna Evans Phillips
NCT03434392
MIVetsCan: Can-Coach Trial (Phase 2)
University of Michigan
NCT06283862
Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain
Rush University Medical Center
NCT06044649
Stanford Pragmatic Effectiveness Comparison
Stanford University
NCT04441034
Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial
VA Office of Research and Development
NCT07149870
Overlapping Pain Trajectory Study
Children's Hospital Medical Center, Cincinnati
NCT05752396
Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention
Florida State University
NCT07335159
Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline
Massachusetts General Hospital
NCT06246929
Telehealth for Pain and Unhealthy Drinking Among PLWH
Boston University
NCT05503173
Partners4Pain & Wellbeing: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain
University of Minnesota
NCT06696352
CARES-Spine (Comprehensive Analgesic, Recovery, and Education Support for Spine Surgery) Trial
Stanford University
NCT06027099
Group-based Integrative Pain Management in Primary Care Safety Net Clinics
University of California, San Francisco
NCT06327542
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Rush University Medical Center
NCT05700279
HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
Rhode Island Hospital
NCT06931158
Equipping Patients Using Interventions for Pain and Depression
Indiana University
NCT06500780
Under-Resourced Adults With Chronic Pain eHealth Study
Mayo Clinic
NCT06688864
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Hugo W. Moser Research Institute at Kennedy Krieger
NCT05197946
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
University of Utah
NCT06387290
Individual Differences in Gait and Osteoarthritis Pain
University of Pittsburgh
NCT07308873
Better Options for Chronic Cancer Pain
VA Office of Research and Development
NCT06574009
Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain
Palo Alto Veterans Institute for Research
NCT06704061
Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain
VA Office of Research and Development
NCT06058624
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
Medical University of South Carolina
NCT06442566
EPPIC: Easing Pelvic Pain Interventions Clinical Research Program
State University of New York at Buffalo
NCT05127616
Examining Racial and Socioeconomic Differences in Chronic Low Back Pain
Washington University School of Medicine
NCT05991440
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial
St. Jude Children's Research Hospital
NCT07160621
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
University of New Mexi
NCT06565416
Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)
Evon Medics
NCT06671132
Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain
Cambridge Health Alliance
NCT06515925
Stepped Care for Patients to Optimize Whole Recovery
Yale University
NCT05155163
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
University of Pittsburgh
NCT06855732
A Mobile Intervention to Reduce Pain and Improve Health-III
Wake Forest University
NCT06623669
Virtual Reality Treatment for Adults With Chronic Back Pain (VRNT)
CognifiSense
NCT07033195
Improving Health for Older Adults With Pain Through Engagement
Massachusetts General Hospital
NCT06119698
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Pain page
302 registered trials, 139 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 139 Chronic Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Pain condition card totals 302 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.