Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Trial of Parkinson's And Zoledronic Acid
NCT03924414 · View on ClinicalTrials.gov ↗
Study Summary
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 2650 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the National Institute of Aging.
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Zoledronic Acid 5Mg/Bag 100Ml Inj
Study Locations (20)
California
- Sutter Health — Berkeley
- Parkinson's and Movement Disorder Institute — Fountain Valley
- University of California, Irvine — Irvine
- Loma Linda University — Loma Linda
- Cedars-Sinai Medical Center — Los Angeles
- University of California, Los Angeles — Los Angeles
- Valley Parkinson Clinic — Los Gatos
- Parkinson's Disease and Movement Disorder Center of Silicon Valley — Palo Alto
- University of California, Riverside — Riverside
- Sutter Health — Sacramento
- University of California, Davis — Sacramento
- University of California, San Francisco — San Francisco
Connecticut
- University of Connecticut — Farmington
- University of Connecticut — Farmington
- Hartford Healthcare — Hartford
Arkansas
- Washington Regional Medical Center — Fayetteville
- University of Arkansas for Medical Sciences — Little Rock
Colorado
- University of Colorado, Denver — Aurora
- St. Mary's Medical Center — Grand Junction
Arizona
- Mayo Clinic — Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,650 participants |
| Start Date | 2019-11-15 |
| Est. Completion | 2025-10-31 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03924414
The ClinicalTrials.gov registry entry for NCT03924414 describes a study currently listed as active not recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,650 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is California Pacific Medical Center Research Institute, which has 9 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 9 conditions, with Parkinson Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03924414 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Connecticut, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03924414 about?
NCT03924414 is a clinical study titled "Trial of Parkinson's And Zoledronic Acid". This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 2650 participants w...
What is the current status of trial NCT03924414?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 2,650 participants. The study started on 2019-11-15. Estimated completion is 2025-10-31.
What conditions does trial NCT03924414 study?
This clinical trial studies the following conditions: Parkinson Disease, Osteoporosis, Multiple System Atrophy, Dementia With Lewy Bodies, Progressive Supranuclear Palsy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03924414?
The interventions under investigation include: Placebo (OTHER), Zoledronic Acid 5Mg/Bag 100Ml Inj (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03924414?
This trial is sponsored by California Pacific Medical Center Research Institute, which has 9 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03924414 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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