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NCT04650932 · ClinicalTrials.gov registry record · NA
Dual Frequency Stimulation in Parkinson's Disease
A NA study of Parkinson Disease, sponsored by University of California, Davis.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04650932: Recruiting NA study of Parkinson Disease, sponsored by University of California, Davis.
NCT04650932 is a NA study of Parkinson Disease that is actively recruiting participants, run by University of California, Davis. The registered enrollment target is 10 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04650932, a NA study of Parkinson Disease, is actively recruiting participants, sponsored by University of California, Davis.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result, current stimulation parameters often lead to worsening in verbal fluency, executive function, and, particularly, cognitive control. There is evidence suggesting that low frequency oscillatory activity occurs across brain circuits important in integrating information for cognition. Preclinical studies and human recording studies indicate these low frequency theta oscillations drive cognitive control during cognitive tasks. Thus, the purpose of this study is to determine the safety, tolerability, and efficacy of low frequency stimulation (LFS) of the ventral STN alongside standard high frequency stimulation (HFS) of the dorsal STN in patients with PD.
Primary Outcome
The score of the CES-D will be compared across sessions and a score that rises above 20 (out of 60) will be considered positive for the development of depression.
Conditions Studied
Interventions
- DEVICE Deep brain stimulation
Study Locations (1)
California
- UC Davis Health - Sacramento
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-10-22 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT04650932 shows while recruiting
NCT04650932 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Parkinson Disease appearing as the primary indexed condition, and to 1 intervention - of which Deep brain stimulation is the first listed.
NCT04650932 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04650932 about?
NCT04650932 is a clinical study titled "Dual Frequency Stimulation in Parkinson's Disease". Deep brain stimulation (DBS) in the dorsal region of the subthalamic nucleus (STN) is very effective for reducing motor symptoms of Parkinson's disease (PD). Modeling studies suggest that this therapy may result in current spread into the ventral STN, causing altered cognitive processes. As a result...
What is the current status of trial NCT04650932?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2022-10-22. Estimated completion is 2026-06-30.
What conditions does trial NCT04650932 study?
This clinical trial studies the following conditions: Parkinson Disease.
What interventions are being tested in trial NCT04650932?
The interventions under investigation include: Deep brain stimulation (DEVICE).
Who is sponsoring clinical trial NCT04650932?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04650932 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Parkinson Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04650932's enrollment target sits among peer trials
10 276th of 297 higher than 11 of 297 other Parkinson Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Parkinson Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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