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NCT04768101 · ClinicalTrials.gov registry record · Early Phase 1
Quantitative Imaging of Brain Glymphatic Function in Humans
A Early Phase 1 study of Parkinson Disease, sponsored by Vanderbilt University Medical Center.
- Active
- Registry status
- Early Phase 1
- Development phase
- 140
- Enrollment target
- 1
- Study location
NCT04768101 is a Early Phase 1 study of Parkinson Disease that is active but no longer recruiting, run by Vanderbilt University Medical Center. The registered enrollment target is 140 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04768101, a Early Phase 1 study of Parkinson Disease, is active but no longer recruiting, sponsored by Vanderbilt University Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 140 participants
- Enrollment target
- 1
- Study location
Study Summary
Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system exists in humans. If operative, this system may have central relevance to many vascular and fluid clearance disorders such as stroke, multiple sclerosis, Parkinson's disease, and Alzheimer's disease related dementia (ADRD): diseases which represent some of the most pressing healthcare challenges of the 21st century. Evaluating this possibility will require improved, robust imaging methods sensitive to lymphatic drainage dysfunction; as such, the goal of this work is to apply novel magnetic resonance imaging approaches, optimized already for evaluating lymphatic circulation in patients with peripheral lymphatic dysfunction, to quantify relationships between physiological hallmarks of ADRD and CNS lymphatic function in humans.
Conditions Studied
Interventions
- DRUG [11C]-PIB
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2020-04-15 |
| Est. Completion | 2025-12-31 |
| Phase | Early Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04768101
The ClinicalTrials.gov registry entry for NCT04768101 describes a study currently listed as active not recruiting, categorized as Early Phase 1. The registered enrollment target is 140 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (97% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Parkinson Disease appearing as the primary indexed condition, and to 1 intervention - of which [11C]-PIB is the first listed.
NCT04768101 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT04768101 about?
NCT04768101 is a clinical study titled "Quantitative Imaging of Brain Glymphatic Function in Humans". Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system exists in humans. If operative, this system may have central relevance to m...
What is the current status of trial NCT04768101?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 140 participants. The study started on 2020-04-15. Estimated completion is 2025-12-31.
What conditions does trial NCT04768101 study?
This clinical trial studies the following conditions: Parkinson Disease.
What interventions are being tested in trial NCT04768101?
The interventions under investigation include: [11C]-PIB (DRUG).
Who is sponsoring clinical trial NCT04768101?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04768101 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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