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NCT05307055 · ClinicalTrials.gov registry record · NA
Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation
A NA study of Parkinson Disease, sponsored by University of Southern California.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05307055: Recruiting NA study of Parkinson Disease, sponsored by University of Southern California.
NCT05307055 is a NA study of Parkinson Disease that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 40 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05307055, a NA study of Parkinson Disease, is actively recruiting participants, sponsored by University of Southern California.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.
Primary Outcome
Effects of theta burst stimulation on changes in baseline motor symptoms will be assessed using the MDS-Unified Parkinson's Disease Rating Scale - Sections III\&IV (MDS-UPDRS III\&IV)
Conditions Studied
Interventions
- DEVICE STN DBS - Theta Burst
- DEVICE STN DBS - Gamma
Study Locations (1)
California
- University of Southern California Keck School of Medicine - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-01-11 |
| Est. Completion | 2029-08-31 |
| Phase | NA |
What NCT05307055 shows while recruiting
NCT05307055 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Parkinson Disease appearing as the primary indexed condition, and to 2 interventions - of which STN DBS - Theta Burst is the first listed.
NCT05307055 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05307055 about?
NCT05307055 is a clinical study titled "Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation". This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and bei...
What is the current status of trial NCT05307055?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2022-01-11. Estimated completion is 2029-08-31.
What conditions does trial NCT05307055 study?
This clinical trial studies the following conditions: Parkinson Disease.
What interventions are being tested in trial NCT05307055?
The interventions under investigation include: STN DBS - Theta Burst (DEVICE), STN DBS - Gamma (DEVICE).
Who is sponsoring clinical trial NCT05307055?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05307055 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05307055's enrollment target sits among peer trials
40 173rd of 297 higher than 109 of 297 other Parkinson Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Parkinson Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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