Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05489575 · ClinicalTrials.gov registry record · NA
CPAP for the Treatment of Supine Hypertension
A NA study of Parkinson Disease and Multiple System Atrophy, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 59
- Enrollment target
- 1
- Study location
NCT05489575: Recruiting NA study of Parkinson Disease and Multiple System Atrophy, sponsored by Vanderbilt University Medical Center.
NCT05489575 is a NA study of Parkinson Disease and Multiple System Atrophy that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 59 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05489575, a NA study of Parkinson Disease and Multiple System Atrophy, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 59 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment for sleep apnea) involves using a machine that blows air into a tube connected to a mask covering the nose, or nose and mouth, to apply a low air pressure in the airways. The study includes 3-5 days spent in the Vanderbilt Clinical Research Center (CRC): at least one day of screening tests, followed by up to 3 study days. Subjects may be able to participate in daytime and/or overnight studies. The Daytime study consists of 2 study days: one with active CPAP and one with sham CPAP applied for up to 2 hours. The Overnight study consists of 3 study nights: one with active CPAP, one with sham CPAP, both applied for up to 9 hours and one night sleeping with the bed tilted head-up.
Primary Outcome
Change from baseline in systolic blood pressure at 2 hours of the intervention
Conditions Studied
Interventions
- DEVICE Active CPAP
- DEVICE Sham CPAP
- OTHER Sleeping in a head-up tilt (HUT) position
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center/ Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2022-06-23 |
| Est. Completion | 2026-08-31 |
| Phase | NA |
What NCT05489575 shows while recruiting
NCT05489575 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 59 participants, a relatively small participant target, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower).
The record links to 6 conditions, with Parkinson Disease appearing as the primary indexed condition, and to 3 interventions - of which Active CPAP is the first listed.
NCT05489575 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT05489575 about?
NCT05489575 is a clinical study titled "CPAP for the Treatment of Supine Hypertension". This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment fo...
What is the current status of trial NCT05489575?
This trial is currently recruiting. It is a NA study. The enrollment target is 59 participants. The study started on 2022-06-23. Estimated completion is 2026-08-31.
What conditions does trial NCT05489575 study?
This clinical trial studies the following conditions: Parkinson Disease, Multiple System Atrophy, Autonomic Failure, Pure Autonomic Failure, Neurogenic Orthostatic Hypotension.
What interventions are being tested in trial NCT05489575?
The interventions under investigation include: Active CPAP (DEVICE), Sham CPAP (DEVICE), Sleeping in a head-up tilt (HUT) position (OTHER).
Who is sponsoring clinical trial NCT05489575?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05489575 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Parkinson Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05489575's enrollment target sits among peer trials
59 145th of 297 higher than 153 of 297 other Parkinson Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Parkinson Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Evaluation of Correlation Between Oculometric Measures and Clinical Assessment in Parkinson's Disease
RECRUITING · NA
-
Neocortical Microarchitecture of Executive Function
RECRUITING · NA
-
Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)
RECRUITING · NA
-
Neurophysiology of Reward Signaling in Parkinson's Disease
RECRUITING · NA
-
Balance Tele-Rehab in Parkinson's Disease Parkinson's Disease
RECRUITING · NA
-
Rock Steady Boxing: A Community Based In Person Class
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03801083 · 59 participants · Phase 2
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Biliary Tract Cancers
- NCT04332367 · 59 participants · Phase 2
Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance
- NCT06721689 · 59 participants · Phase 1
PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors
- NCT06722807 · 59 participants · NA
ClAmpless, Sutureless PartIAl Nephrectomy for Renal Masses
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI