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NCT05489575 · ClinicalTrials.gov registry record · NA
CPAP for the Treatment of Supine Hypertension
A NA study of Parkinson Disease and Multiple System Atrophy, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 59
- Enrollment target
- 1
- Study location
NCT05489575 is a NA study of Parkinson Disease and Multiple System Atrophy that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 59 participants, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05489575, a NA study of Parkinson Disease and Multiple System Atrophy, is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 59 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment for sleep apnea) involves using a machine that blows air into a tube connected to a mask covering the nose, or nose and mouth, to apply a low air pressure in the airways. The study includes 3-5 days spent in the Vanderbilt Clinical Research Center (CRC): at least one day of screening tests, followed by up to 3 study days. Subjects may be able to participate in daytime and/or overnight studies. The Daytime study consists of 2 study days: one with active CPAP and one with sham CPAP applied for up to 2 hours. The Overnight study consists of 3 study nights: one with active CPAP, one with sham CPAP, both applied for up to 9 hours and one night sleeping with the bed tilted head-up.
Conditions Studied
Interventions
- DEVICE Active CPAP
- DEVICE Sham CPAP
- OTHER Sleeping in a head-up tilt (HUT) position
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center/ Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2022-06-23 |
| Est. Completion | 2026-08-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05489575
The ClinicalTrials.gov registry entry for NCT05489575 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 5,326-participant average among 297 other Parkinson Disease trials with a reported enrollment target (99% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 6 conditions, with Parkinson Disease appearing as the primary indexed condition, and to 3 interventions - of which Active CPAP is the first listed.
NCT05489575 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.
Frequently Asked Questions
What is clinical trial NCT05489575 about?
NCT05489575 is a clinical study titled "CPAP for the Treatment of Supine Hypertension". This study aims to learn about the effects of continuous positive airway pressure (CPAP) on people with autonomic failure and high blood pressure when lying down (supine hypertension) to determine if it can be used to treat their high blood pressure during the night. CPAP (a widely used treatment fo...
What is the current status of trial NCT05489575?
This trial is currently recruiting. It is a NA study. The enrollment target is 59 participants. The study started on 2022-06-23. Estimated completion is 2026-08-31.
What conditions does trial NCT05489575 study?
This clinical trial studies the following conditions: Parkinson Disease, Multiple System Atrophy, Autonomic Failure, Pure Autonomic Failure, Neurogenic Orthostatic Hypotension.
What interventions are being tested in trial NCT05489575?
The interventions under investigation include: Active CPAP (DEVICE), Sham CPAP (DEVICE), Sleeping in a head-up tilt (HUT) position (OTHER).
Who is sponsoring clinical trial NCT05489575?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05489575 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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