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ClinicalTrials.gov 50 recruiting now official registry

Overweight clinical trials

50 of 198 indexed Overweight trials are currently recruiting.

198 US clinical trials · 50 currently recruiting

Overweight is the subject of 198 registered US clinical trials on ClinicalTrials.gov, 50 of them currently open to new participants. 37 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 37 of these trials.

The research picture

Overweight has 198 registered US clinical trials, 50 of them open to new participants right now, about 25% of the total.

50
recruiting participants now
25%
of trials open to enrollment
37
in Phase 3–4 (later-stage)
37
top sponsor: Eli Lilly and Company
Phase 121Phase 225Phase 336Phase 41

Active & Recent Trials

198 total, page 2 of 4

ACTIVE NOT RECRUITING 60,000 participants

INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)

Brigham and Women's Hospital

NCT07417618

ACTIVE NOT RECRUITING Phase 3 15,374 participants

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Eli Lilly and Company

NCT05556512

ACTIVE NOT RECRUITING NA 5,000 participants

Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0

Brigham and Women's Hospital

NCT05553925

ACTIVE NOT RECRUITING Phase 3 3,127 participants

A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT05869903

ACTIVE NOT RECRUITING Phase 3 2,749 participants

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Eli Lilly and Company

NCT05803421

ACTIVE NOT RECRUITING Phase 3 2,300 participants

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929066

ACTIVE NOT RECRUITING Phase 3 1,000 participants

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929079

ACTIVE NOT RECRUITING Phase 3 905 participants

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06914895

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING Phase 3 465 participants

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06962280

ACTIVE NOT RECRUITING NA 440 participants

TOTAL: A Multisite RCT

VA Office of Research and Development

NCT05346575

ACTIVE NOT RECRUITING Phase 3 400 participants

A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT06047548

ACTIVE NOT RECRUITING Phase 2 350 participants

A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes

Eli Lilly and Company

NCT06603571

ACTIVE NOT RECRUITING Phase 1 348 participants

Comparing the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous (SC) Presentations

Amgen

NCT07226778

ACTIVE NOT RECRUITING Phase 3 330 participants

Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide

Novo Nordisk A/S

NCT07220759

ACTIVE NOT RECRUITING Phase 1 302 participants

A Study of LY3537031 in Overweight, Obese, and Healthy Participants

Eli Lilly and Company

NCT06606106

ACTIVE NOT RECRUITING NA 300 participants

NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers

New York University

NCT05461495

ACTIVE NOT RECRUITING Phase 3 300 participants

Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide

Novo Nordisk A/S

NCT07220642

ACTIVE NOT RECRUITING Phase 2 288 participants

A Study to Investigate Weight Management With LY3549492 Compared With Placebo in Adult Participants With Obesity or Overweight

Eli Lilly and Company

NCT06683508

ACTIVE NOT RECRUITING Phase 2 285 participants

A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

Hoffmann-La Roche

NCT06965413

ACTIVE NOT RECRUITING Phase 2 240 participants

A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight

Eli Lilly and Company

NCT06643728

ACTIVE NOT RECRUITING Phase 4 226 participants

A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)

WW International

NCT06605703

ACTIVE NOT RECRUITING Phase 2 221 participants

Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)

Zealand Pharma

NCT06926842

ACTIVE NOT RECRUITING Phase 2 206 participants

A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Verdiva Bio Dev Limited

NCT07281937

ACTIVE NOT RECRUITING NA 175 participants

Promotion of Weight Management

VA Office of Research and Development

NCT04131647

ACTIVE NOT RECRUITING Phase 3 150 participants

A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT06075667

ACTIVE NOT RECRUITING Phase 2 150 participants

Taldefgrobep Alfa in Adults With Overweight and Obesity

Biohaven Therapeutics

NCT07281495

ACTIVE NOT RECRUITING Phase 2 140 participants

A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Eli Lilly and Company

NCT05536804

ACTIVE NOT RECRUITING NA 100 participants

A Study of Time Restricted Eating in Obese Adults

Mayo Clinic

NCT05660291

ACTIVE NOT RECRUITING Phase 2 82 participants

A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

NCT06703021

ACTIVE NOT RECRUITING Phase 1 81 participants

Effect of Maridebart Cafraglutide on the Heart's Electrical Activity

Amgen

NCT07229157

ACTIVE NOT RECRUITING Phase 2 80 participants

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

Massachusetts General Hospital

NCT05774665

ACTIVE NOT RECRUITING NA 68 participants

Piloting a Patient Navigator Program for Weight Loss

Drexel University

NCT06972381

ACTIVE NOT RECRUITING Phase 1 63 participants

A Research Study on How NNC0638-0355, a New Medicine, Works in People Living With Overweight or Obesity

Novo Nordisk A/S

NCT06577766

ACTIVE NOT RECRUITING NA 60 participants

Study to Evaluate the Efficacy of an Avocado Dietary Supplement

SP Nutraceuticals

NCT07354308

ACTIVE NOT RECRUITING NA 51 participants

Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants

M.D. Anderson Cancer Center

NCT03546972

ACTIVE NOT RECRUITING NA 50 participants

The Effects of Almond Consumption on Functional Performance and Activity in Overweight Active Older Adults

Florida State University

NCT04778371

ACTIVE NOT RECRUITING 50 participants

Variety of Physical Activity in Normal to Overweight Adults Who Are Regularly Active

The University of Tennessee, Knoxville

NCT02149147

ACTIVE NOT RECRUITING NA 44 participants

Olive Oil Polyphenols and Cardiovascular Health Biomarkers

University of California, Davis

NCT04149288

ACTIVE NOT RECRUITING NA 40 participants

Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

Joslin Diabetes Center

NCT03860558

ACTIVE NOT RECRUITING NA 40 participants

Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes

Brigham and Women's Hospital

NCT05560971

ACTIVE NOT RECRUITING 36 participants

Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)

AdventHealth Translational Research Institute

NCT01745471

ACTIVE NOT RECRUITING NA 25 participants

Study of the Carbon Dioxide Treatment for Fat Reduction

Northwestern University

NCT00974415

ACTIVE NOT RECRUITING NA 20 participants

Family-Based Treatment for Type 1 Diabetes

State University of New York at Buffalo

NCT05756361

ACTIVE NOT RECRUITING NA 20 participants

Enhancing Mental and Physical Health of Women Veterans

VA Office of Research and Development

NCT05050266

COMPLETED NA 3,765 participants

Mass in Motion Kids in the Clinical Setting

Massachusetts General Hospital

NCT02110615

COMPLETED 3,439 participants

SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial

Novo Nordisk A/S

NCT04972721

COMPLETED NA 2,600 participants

Electronic Tools to Assist With Identification of and Counseling for Overweight Patients

Northwestern University

NCT00973661

COMPLETED Phase 3 1,613 participants

A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

Eli Lilly and Company

NCT05872620

COMPLETED Phase 3 1,210 participants

Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity

Novo Nordisk A/S

NCT03552757

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Phase Distribution

PhaseTrial count
Phase 1 21
Phase 2 25
Phase 3 36
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight Trial Landscape

198 indexed Overweight studies · 50 recruiting (25%).

Phase mix: 37 late (III/IV) vs 46 early (I/II).

Top sponsor: Eli Lilly and Company (37 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight?

PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.