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ACTIVE NOT RECRUITING Phase 2

Taldefgrobep Alfa in Adults With Overweight and Obesity

NCT07281495 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, randomized, double-blind, placebo-controlled, multiple dose study to evaluate the efficacy, safety, and tolerability of taldefgrobep alfa in adults with overweight and obesity, with an open-label extension.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Taldefgrobep Alfa

Study Locations (20)

California

  • Site-001 — Chula Vista
  • Site-014 — Montclair
  • Site-011 — Sacramento
  • Site-018 — Tustin

Florida

  • Site-020 — Orlando
  • Site-008 — Palm Springs
  • Site-015 — St. Petersburg

Texas

  • Site-005 — Austin
  • Site-012 — McKinney
  • Site-013 — San Antonio

Louisiana

  • Site-010 — Baton Rouge
  • Site-009 — Metairie

Missouri

  • Site-006 — City of Saint Peters
  • Site-003 — Springfield

Illinois

  • Site-007 — Chicago

Indiana

  • Site-016 — Indianapolis

North Carolina

  • Site-019 — Monroe

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 2025-11-24
Est. Completion 2026-09
Phase Phase 2

Sponsor

Biohaven Therapeutics

65 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07281495

The ClinicalTrials.gov registry entry for NCT07281495 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Biohaven Therapeutics, which has 65 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07281495 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Florida, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07281495 about?

NCT07281495 is a clinical study titled "Taldefgrobep Alfa in Adults With Overweight and Obesity". This is a multicenter, randomized, double-blind, placebo-controlled, multiple dose study to evaluate the efficacy, safety, and tolerability of taldefgrobep alfa in adults with overweight and obesity, with an open-label extension.

What is the current status of trial NCT07281495?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2025-11-24. Estimated completion is 2026-09.

What conditions does trial NCT07281495 study?

This clinical trial studies the following conditions: Obesity, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07281495?

The interventions under investigation include: Placebo (DRUG), Taldefgrobep Alfa (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07281495?

This trial is sponsored by Biohaven Therapeutics, which has 65 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07281495 being conducted?

This trial has 20 study locations across California, Florida, Illinois, Indiana, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial