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ACTIVE NOT RECRUITING Phase 3

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

NCT05929079 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of participants who have obstructive sleep apnea (OSA) (J1I-MC-GSA2). The study will last about 89 weeks and will include up to 24 visits.

Interventions

  • DRUG Placebo
  • DRUG Retatrutide

Study Locations (20)

Florida

  • Excel Medical Clinical Trials — Boca Raton
  • Teradan Clinical Trials, LLC — Brandon
  • Fleming Island Center for Clinical Research — Fleming Island
  • Therafirst Medical Center — Fort Lauderdale
  • Clinical Site Partners LLC, dba Flourish Research — Miami
  • Quantum Clinical Trials — Miami Beach
  • Renstar Medical Research — Ocala
  • Clinical Research Center of Florida — Pompano Beach
  • Palm Beach Research Center — West Palm Beach
  • Clinical Site Partners, LLC dba Flourish Research — Winter Park

California

  • Core Healthcare Group — Cerritos
  • Velocity Clinical Research, Westlake — Los Angeles
  • Valley Clinical Trials, Inc. — Northridge
  • Diablo Clinical Research, Inc. — Walnut Creek

Alabama

  • Pinnacle Research Group, LLC — Anniston
  • Cullman Clinical Trials — Cullman

Georgia

  • NeuroTrials Research Inc — Atlanta
  • Centricity Research Rincon Pulmonology — Rincon

Arkansas

  • Preferred Research Partners — Little Rock

Connecticut

  • Chase Medical Research, LLC — Waterbury

Trial Details

FieldValue
Enrollment Target 1,000 participants
Start Date 2023-07-11
Est. Completion 2026-05
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05929079

The ClinicalTrials.gov registry entry for NCT05929079 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05929079 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Florida, California, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05929079 about?

NCT05929079 is a clinical study titled "A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight". The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of participants who have obstructive sleep apnea (OSA) (J1I-MC-GSA2). The study w...

What is the current status of trial NCT05929079?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,000 participants. The study started on 2023-07-11. Estimated completion is 2026-05.

What conditions does trial NCT05929079 study?

This clinical trial studies the following conditions: Obesity, Type 2 Diabetes, Overweight, Obstructive Sleep Apnea. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05929079?

The interventions under investigation include: Placebo (DRUG), Retatrutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05929079?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05929079 being conducted?

This trial has 20 study locations across Alabama, Arkansas, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial