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Overweight clinical trials
50 of 198 indexed Overweight trials are currently recruiting.
198 US clinical trials · 50 currently recruiting
Overweight is the subject of 198 registered US clinical trials on ClinicalTrials.gov, 50 of them currently open to new participants. 37 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 37 of these trials.
The research picture
Overweight has 198 registered US clinical trials, 50 of them open to new participants right now, about 25% of the total.
- 50
- recruiting participants now
- 25%
- of trials open to enrollment
- 37
- in Phase 3–4 (later-stage)
- 37
- top sponsor: Eli Lilly and Company
Active & Recent Trials
198 total, page 3 of 4
Delivering Geospatial Intelligence to Health Care Providers
Indiana University
NCT01567228
Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)
Novo Nordisk A/S
NCT05035095
A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program
Eli Lilly and Company
NCT04657016
Mothers in Motion Program to Prevent Weight Gain in WIC Mothers (MIM)
Ohio State University
NCT01839708
A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes
Orexigen Therapeutics
NCT00474630
A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults
Novartis Pharmaceuticals
NCT03100058
Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension
Novartis Pharmaceuticals
NCT00219141
Targeting Inflammation Using Salsalate in CardioVascular Disease
Joslin Diabetes Center
NCT00624923
Growing Resilience in Wind River Indian Reservation
University of Wyoming
NCT02672748
A Study of LY3437943 in Participants Who Have Obesity or Are Overweight
Eli Lilly and Company
NCT04881760
Multicenter Worksite Nutrition Study
Physicians Committee for Responsible Medicine
NCT01224548
A Randomized Trial of Recommendations for Exercise to Prevent Weight Regain
University of Kansas
NCT01664715
Toddler Overweight Prevention Study Among Low-Income Families
University of Maryland, Baltimore
NCT02615158
Weight Watchers Online
The Miriam Hospital
NCT01888172
A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
AstraZeneca
NCT00402077
Barriers to Effective Weight Loss in Overweight Adolescents
Virginia Commonwealth University
NCT00562263
Dissemination of the Look Ahead Weight Management Treatment in the Military
University of Tennessee
NCT02063178
Effect of South Beach Diet (SBD™) Using SBD™ Products Compared to a Calorie-Restricted Diet in Women
Mondelēz International
NCT00932516
Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects
Orexigen Therapeutics
NCT01764386
Families Improving Together (FIT) for Weight Loss
University of South Carolina
NCT01796067
Weight Loss Maintenance in Primary Care
Drexel University
NCT00455780
Ethnic Dance and Screen Time Reduction to Prevent Weight Gain in Latina Girls
Stanford University
NCT00476775
UCSD Take Charge Study
University of California, San Diego
NCT01345500
Examining the Feasibility of Collaborative Care Treatment for Overweight Adolescents
Kaiser Permanente
NCT00462267
mFit: The Mobile Fitness Project
University of California, Los Angeles
NCT01650337
Eating Peanuts for Health
Purdue University
NCT01886326
Strong Hearts: Rural CVD Prevention
Cornell University
NCT02499731
Spark: Finding the Optimal Tracking Strategy for Weight Loss in a Digital Health Intervention
Stanford University
NCT05249465
Lorcaserin: Real World Experience in an Insurance-Based Weight Management Clinic
Scripps Whittier Diabetes Institute
NCT03552107
Getting in Balance: A Workplace Diabetes Prevention Intervention Trial
Kaiser Permanente
NCT02589873
Post-delivery Maternal-offspring Obesity and Metabolic Risk After a Prepregnancy Weight-loss Intervention
Kaiser Permanente
NCT06067126
Incentives Targeting Gestational Weight Gain in Overweight/Obese Low Income Women
University of Vermont
NCT02233673
A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight
Eli Lilly and Company
NCT06824051
Self-Efficacy in Weight Loss Treatment
Lora Burke
NCT00896194
Examining the Longitudinal Relationship Between Sleep and Weight Gain in College Students
Oakland University
NCT04100967
A Study of Tirzepatide in Overweight and Very Overweight Participants
Eli Lilly and Company
NCT04311411
Worksite Nutrition Study
Physicians Committee for Responsible Medicine
NCT00481897
Motivating Value of Vegetables Study
USDA Grand Forks Human Nutrition Research Center
NCT02585102
Medications With or Without WeightWatchers
Michelle Cardel, PhD, MS, RD
NCT06470659
Predicting Adherence to a Heart-Healthy Diet in Lean and Obese Individuals
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01862796
A Research Study on How a Dose of NNC0662-0419 Works in Japanese, Chinese and Non-Asian Participants Living With Overweight or Obesity
Novo Nordisk A/S
NCT07101783
PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches
University of North Carolina, Chapel Hill
NCT05929469
A Study of LY3841136 in Overweight and Obese Participants
Eli Lilly and Company
NCT06345066
Weight Watchers Online 2015
The Miriam Hospital
NCT02417220
Exercise Genes: Genomic Association With Exercise Reinforcement
USDA Grand Forks Human Nutrition Research Center
NCT02416882
A School Nurse-Delivered Intervention for Overweight and At Risk Adolescents
University of Massachusetts, Worcester
NCT00682188
Educational Intervention on Weight Management in Chinese-American Children
University of California, San Francisco
NCT00522964
Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)
Johns Hopkins University
NCT00990457
An Interactive Web-based Intervention to Achieve Healthy Weight in Young Children
University of Wisconsin, Madison
NCT01552642
Physical Activity Referrals to the Community
University of California, Berkeley
NCT02044744
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 21 |
| Phase 2 | 25 |
| Phase 3 | 36 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Overweight Trial Landscape
198 indexed Overweight studies · 50 recruiting (25%).
Phase mix: 37 late (III/IV) vs 46 early (I/II).
Top sponsor: Eli Lilly and Company (37 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Overweight?
PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Overweight?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.