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ClinicalTrials.gov 50 recruiting now official registry

Overweight clinical trials

50 of 198 indexed Overweight trials are currently recruiting.

198 US clinical trials · 50 currently recruiting

Overweight is the subject of 198 registered US clinical trials on ClinicalTrials.gov, 50 of them currently open to new participants. 37 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 37 of these trials.

The research picture

Overweight has 198 registered US clinical trials, 50 of them open to new participants right now, about 25% of the total.

50
recruiting participants now
25%
of trials open to enrollment
37
in Phase 3–4 (later-stage)
37
top sponsor: Eli Lilly and Company
Phase 121Phase 225Phase 336Phase 41

Active & Recent Trials

198 total, page 3 of 4

COMPLETED NA 1,076 participants

Delivering Geospatial Intelligence to Health Care Providers

Indiana University

NCT01567228

COMPLETED Phase 3 667 participants

Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1)

Novo Nordisk A/S

NCT05035095

COMPLETED Phase 3 579 participants

A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program

Eli Lilly and Company

NCT04657016

COMPLETED NA 569 participants

Mothers in Motion Program to Prevent Weight Gain in WIC Mothers (MIM)

Ohio State University

NCT01839708

COMPLETED Phase 3 505 participants

A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes

Orexigen Therapeutics

NCT00474630

COMPLETED Phase 2 460 participants

A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults

Novartis Pharmaceuticals

NCT03100058

COMPLETED Phase 3 460 participants

Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension

Novartis Pharmaceuticals

NCT00219141

COMPLETED Phase 2 340 participants

Targeting Inflammation Using Salsalate in CardioVascular Disease

Joslin Diabetes Center

NCT00624923

COMPLETED NA 338 participants

Growing Resilience in Wind River Indian Reservation

University of Wyoming

NCT02672748

COMPLETED Phase 2 338 participants

A Study of LY3437943 in Participants Who Have Obesity or Are Overweight

Eli Lilly and Company

NCT04881760

COMPLETED NA 292 participants

Multicenter Worksite Nutrition Study

Physicians Committee for Responsible Medicine

NCT01224548

COMPLETED NA 287 participants

A Randomized Trial of Recommendations for Exercise to Prevent Weight Regain

University of Kansas

NCT01664715

COMPLETED NA 277 participants

Toddler Overweight Prevention Study Among Low-Income Families

University of Maryland, Baltimore

NCT02615158

COMPLETED NA 270 participants

Weight Watchers Online

The Miriam Hospital

NCT01888172

COMPLETED Phase 2 258 participants

A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects

AstraZeneca

NCT00402077

COMPLETED NA 257 participants

Barriers to Effective Weight Loss in Overweight Adolescents

Virginia Commonwealth University

NCT00562263

COMPLETED NA 248 participants

Dissemination of the Look Ahead Weight Management Treatment in the Military

University of Tennessee

NCT02063178

COMPLETED NA 248 participants

Effect of South Beach Diet (SBD™) Using SBD™ Products Compared to a Calorie-Restricted Diet in Women

Mondelēz International

NCT00932516

COMPLETED Phase 3 242 participants

Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects

Orexigen Therapeutics

NCT01764386

COMPLETED NA 241 participants

Families Improving Together (FIT) for Weight Loss

University of South Carolina

NCT01796067

COMPLETED NA 238 participants

Weight Loss Maintenance in Primary Care

Drexel University

NCT00455780

COMPLETED NA 233 participants

Ethnic Dance and Screen Time Reduction to Prevent Weight Gain in Latina Girls

Stanford University

NCT00476775

COMPLETED NA 227 participants

UCSD Take Charge Study

University of California, San Diego

NCT01345500

COMPLETED Phase 2 215 participants

Examining the Feasibility of Collaborative Care Treatment for Overweight Adolescents

Kaiser Permanente

NCT00462267

COMPLETED NA 212 participants

mFit: The Mobile Fitness Project

University of California, Los Angeles

NCT01650337

COMPLETED NA 196 participants

Eating Peanuts for Health

Purdue University

NCT01886326

COMPLETED NA 194 participants

Strong Hearts: Rural CVD Prevention

Cornell University

NCT02499731

COMPLETED NA 176 participants

Spark: Finding the Optimal Tracking Strategy for Weight Loss in a Digital Health Intervention

Stanford University

NCT05249465

COMPLETED 157 participants

Lorcaserin: Real World Experience in an Insurance-Based Weight Management Clinic

Scripps Whittier Diabetes Institute

NCT03552107

COMPLETED NA 157 participants

Getting in Balance: A Workplace Diabetes Prevention Intervention Trial

Kaiser Permanente

NCT02589873

COMPLETED 154 participants

Post-delivery Maternal-offspring Obesity and Metabolic Risk After a Prepregnancy Weight-loss Intervention

Kaiser Permanente

NCT06067126

COMPLETED NA 136 participants

Incentives Targeting Gestational Weight Gain in Overweight/Obese Low Income Women

University of Vermont

NCT02233673

COMPLETED Phase 1 120 participants

A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight

Eli Lilly and Company

NCT06824051

COMPLETED NA 120 participants

Self-Efficacy in Weight Loss Treatment

Lora Burke

NCT00896194

COMPLETED 116 participants

Examining the Longitudinal Relationship Between Sleep and Weight Gain in College Students

Oakland University

NCT04100967

COMPLETED Phase 1 114 participants

A Study of Tirzepatide in Overweight and Very Overweight Participants

Eli Lilly and Company

NCT04311411

COMPLETED NA 113 participants

Worksite Nutrition Study

Physicians Committee for Responsible Medicine

NCT00481897

COMPLETED NA 102 participants

Motivating Value of Vegetables Study

USDA Grand Forks Human Nutrition Research Center

NCT02585102

COMPLETED NA 101 participants

Medications With or Without WeightWatchers

Michelle Cardel, PhD, MS, RD

NCT06470659

COMPLETED NA 100 participants

Predicting Adherence to a Heart-Healthy Diet in Lean and Obese Individuals

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01862796

COMPLETED Phase 1 100 participants

A Research Study on How a Dose of NNC0662-0419 Works in Japanese, Chinese and Non-Asian Participants Living With Overweight or Obesity

Novo Nordisk A/S

NCT07101783

COMPLETED NA 99 participants

PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches

University of North Carolina, Chapel Hill

NCT05929469

COMPLETED Phase 1 96 participants

A Study of LY3841136 in Overweight and Obese Participants

Eli Lilly and Company

NCT06345066

COMPLETED NA 92 participants

Weight Watchers Online 2015

The Miriam Hospital

NCT02417220

COMPLETED NA 88 participants

Exercise Genes: Genomic Association With Exercise Reinforcement

USDA Grand Forks Human Nutrition Research Center

NCT02416882

COMPLETED Phase 1 84 participants

A School Nurse-Delivered Intervention for Overweight and At Risk Adolescents

University of Massachusetts, Worcester

NCT00682188

COMPLETED Phase 3 80 participants

Educational Intervention on Weight Management in Chinese-American Children

University of California, San Francisco

NCT00522964

COMPLETED Phase 3 77 participants

Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)

Johns Hopkins University

NCT00990457

COMPLETED Phase 3 77 participants

An Interactive Web-based Intervention to Achieve Healthy Weight in Young Children

University of Wisconsin, Madison

NCT01552642

COMPLETED NA 76 participants

Physical Activity Referrals to the Community

University of California, Berkeley

NCT02044744

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Phase Distribution

PhaseTrial count
Phase 1 21
Phase 2 25
Phase 3 36
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight Trial Landscape

198 indexed Overweight studies · 50 recruiting (25%).

Phase mix: 37 late (III/IV) vs 46 early (I/II).

Top sponsor: Eli Lilly and Company (37 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight?

PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.