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Overweight clinical trials
50 of 198 indexed Overweight trials are currently recruiting.
198 US clinical trials · 50 currently recruiting
Overweight is the subject of 198 registered US clinical trials on ClinicalTrials.gov, 50 of them currently open to new participants. 37 are in Phase 3-4 (later-stage) and 46 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 37 of these trials.
The research picture
Overweight has 198 registered US clinical trials, 50 of them open to new participants right now, about 25% of the total.
- 50
- recruiting participants now
- 25%
- of trials open to enrollment
- 37
- in Phase 3–4 (later-stage)
- 37
- top sponsor: Eli Lilly and Company
Active & Recent Trials
198 total, page 1 of 4
International Weight Control Registry
Tufts University
NCT04907396
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Amgen
NCT07037433
Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study
Duke University
NCT06595251
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
Eli Lilly and Company
NCT07321886
Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
Kailera
NCT07284875
Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)
Memorial Sloan Kettering Cancer Center
NCT05770570
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Eli Lilly and Company
NCT06143956
A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
Eli Lilly and Company
NCT06993792
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
Eli Lilly and Company
NCT07282600
Community Park-Based Programs for Health Promotion: Active Older Adults Prospective Cohort Study
Duke University
NCT06604650
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
Eli Lilly and Company
NCT07392190
A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Eli Lilly and Company
NCT07369011
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
Eli Lilly and Company
NCT06972459
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
Eli Lilly and Company
NCT06972472
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
Eli Lilly and Company
NCT07357415
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Eli Lilly and Company
NCT07035093
Avoid and Resist Strategies for Weight Management
Cedars-Sinai Medical Center
NCT05143931
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
Novo Nordisk A/S
NCT07253285
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
University of Pittsburgh
NCT05655936
A Research Study on How Well Different Doses of the Medicine UBT251 Help People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07395687
HealthyTogether: RCT of a Dyadic Weight Management Intervention
VA Office of Research and Development
NCT06619041
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Eli Lilly and Company
NCT07232719
A Research Study on How Well Different Doses of the Medicine NNC0662-0419 Help People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07184632
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
Eli Lilly and Company
NCT06945419
A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes
Eli Lilly and Company
NCT07215559
Semaglutide for Post-Smoking Cessation Weight Management
The University of Texas Health Science Center, Houston
NCT06173778
Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients
Nitinotes Surgical
NCT07090005
Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers
Salk Institute for Biological Studies
NCT06891352
A Study on How NNC0174-1213 Works in People With Overweight or Obesity.
Novo Nordisk A/S
NCT06719011
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT03407079
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
Eli Lilly and Company
NCT06672549
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Eli Lilly and Company
NCT06672939
A Study of LY3549492 in Healthy Participants and Participants With Overweight or Obesity
Eli Lilly and Company
NCT07232732
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06044935
A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity
Novo Nordisk A/S
NCT07437079
Time Restricted Feeding, Muscle, and Metabolism
University of Arkansas, Fayetteville
NCT04949451
A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy
Eli Lilly and Company
NCT07225556
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
Georgia State University
NCT06735599
Night Owl Metabolism
Johns Hopkins University
NCT06507722
Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
Stanford University
NCT05912621
A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults
Shanghai World Leader Pharmaceutical Co.
NCT07465965
Improving Glycemic Control With Electrical Stimulation
University of Texas, El Paso
NCT03947697
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Cornell University
NCT06557317
A Study to Learn How the Study Medicine Called PF-08653944 is Taken up Into the Blood in Adults With Overweight or Obesity.
Pfizer
NCT07400679
Nutrition and Exercise Interventions in Reducing Androgen Deprivation Therapy-Induced Obese Frailty in Prostate Cancer Survivors
Roswell Park Cancer Institute
NCT03880422
Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06325722
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
Georgia State University
NCT06735651
Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
Massachusetts General Hospital
NCT05799222
The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.
University of California, Davis
NCT04248127
Dietary Supplementation on Fat Oxidation
Brightseed
NCT06548048
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 21 |
| Phase 2 | 25 |
| Phase 3 | 36 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Overweight Trial Landscape
198 indexed Overweight studies · 50 recruiting (25%).
Phase mix: 37 late (III/IV) vs 46 early (I/II).
Top sponsor: Eli Lilly and Company (37 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Overweight?
PlainTrial tracks 198 US clinical trials for Overweight, of which 50 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Overweight?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.