Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Type 1 Diabetes

Open-data reference.

179 US clinical trials · 69 currently recruiting

Active & Recent Trials

RECRUITING 50,000 participants

The T1D Exchange Registry

T1D Exchange, United States

NCT04629586

RECRUITING 33,000 participants

General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery

Sanford Health

NCT04477928

RECRUITING 6,000 participants

PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life

University of Colorado, Denver

NCT06141434

RECRUITING 2,800 participants

Immune Function and the Progression to T1D

University of Florida

NCT05899439

RECRUITING 2,200 participants

Post Market Registry for the Omnipod 5 System in Children and Adults With Type 1 Diabetes

Insulet Corporation

NCT06144554

RECRUITING 1,875 participants

The iLet Experience Study

Beta Bionics

NCT06891898

RECRUITING 1,000 participants

Commercial or Open Source Closed Loop Impact on Pregnancy Study

University of California, San Francis

NCT06654713

RECRUITING 550 participants

A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States

Sanofi

NCT07260110

RECRUITING NA 500 participants

ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2

Johns Hopkins University

NCT05463289

RECRUITING NA 250 participants

EMPoWER Study - Strengths-based Behavioral Intervention for Youth With Type 1 Diabetes

Baylor College of Medicine

NCT06014879

RECRUITING Phase 2 250 participants

ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes

Scripps Whittier Diabetes Institute

NCT04933851

RECRUITING NA 235 participants

Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

Duke University

NCT05540704

RECRUITING NA 216 participants

Family Intervention for Black Teens With Type 1 Diabetes

Wayne State University

NCT06275412

RECRUITING 200 participants

Accessing Care, Clinical Trials and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D)

AdventHealth Translational Research Institute

NCT06908057

RECRUITING 200 participants

Registry for Stage 2 Type 1 Diabetes

Sanofi

NCT06481904

RECRUITING NA 180 participants

Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

Nemours Children's Clinic

NCT05268250

RECRUITING Phase 2 159 participants

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

SAb Biotherapeutics

NCT07187531

RECRUITING NA 150 participants

Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes

University of Colorado, Denver

NCT06297980

RECRUITING NA 150 participants

Sleep Coach for Adolescents With Type 1 Diabetes

Vanderbilt University Medical Center

NCT06516614

RECRUITING NA 150 participants

Discovery Diabetes

Vanderbilt University Medical Center

NCT07116434

RECRUITING Phase 4 125 participants

Cholesterol Lowering and Residual Risk in Diabetes, Type 1

NYU Langone Health

NCT05641753

RECRUITING Phase 1 120 participants

A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes

City of Hope Medical Center

NCT07061574

RECRUITING 120 participants

Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes

University of Colorado, Denver

NCT06575842

RECRUITING Phase 2 114 participants

The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

Heba M. Ismail

NCT05414409

RECRUITING NA 100 participants

A Study Comparing Dexcom Continuous Glucose Monitoring to Point of Care Glucose Testing for the Management of Hospital and Post-Discharge Subjects With Type 1 Diabetes

Emory University

NCT06752928

RECRUITING 100 participants

Pathogenesis of Kidney Disease in Type 1 Diabetes: a Modern Kidney Biopsy Cohort (The PANDA Study)

University of Colorado, Denver

NCT05319990

RECRUITING NA 100 participants

T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes

Yale University

NCT07059806

RECRUITING Phase 2 100 participants

Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years

Massachusetts General Hospital

NCT05866536

RECRUITING NA 96 participants

InvesT1D: Promoting Adolescent Investment in Diabetes Care

Harvard Pilgrim Health Care

NCT06384911

RECRUITING NA 94 participants

Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

Albert Einstein College of Medicine

NCT05734313

RECRUITING NA 93 participants

Reducing Diabetes Distress Using Cognitive Behavioral Therapy in Young Adults With Type 1 Diabetes

Albert Einstein College of Medicine

NCT05000021

RECRUITING 80 participants

Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

Creighton University

NCT05701254

RECRUITING NA 80 participants

Transdisciplinary Care for Young Adults With Type 1 Diabetes

Nemours Children's Clinic

NCT06172166

RECRUITING Phase 1 72 participants

CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

COUR Pharmaceutical Development Company

NCT06783309

RECRUITING Phase 2 70 participants

TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

Emily K. Sims

NCT05594563

RECRUITING Phase 1 60 participants

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

Kalie Tommerdahl

NCT05065372

RECRUITING Phase 2 60 participants

Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

University of Florida

NCT06455319

RECRUITING Phase 2 60 participants

Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

University of Washington

NCT05822609

RECRUITING 60 participants

Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening

Yale University

NCT07155252

RECRUITING Phase 2 60 participants

The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

Mayo Clinic

NCT06976619

RECRUITING NA 60 participants

GO TEAM: Glucose Optimization Through Technology Assisted Management

Sarah MacLeish

NCT06074458

RECRUITING Phase 2 50 participants

Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes

Throne Biotechnologies

NCT04011020

RECRUITING Phase 1 45 participants

Denosumab for Type 1 Diabetes

City of Hope Medical Center

NCT06524960

RECRUITING NA 40 participants

AIDANET At Home Study

Sue Brown

NCT07039617

RECRUITING NA 40 participants

Expansion of the T1DES Pilot to a Public Hospital

Kaiser Permanente

NCT06494722

RECRUITING NA 40 participants

Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes

University of Virginia

NCT05653518

RECRUITING NA 40 participants

Using Simplified Meal Boluses Versus Carbohydrate Counting in Adolescents With Hybrid Closed Loop Systems

University of Colorado, Denver

NCT06575790

RECRUITING Early Phase 1 38 participants

Effect of C-peptide on Hypoglycemic Counterregulation

University of Cincinnati

NCT06470295

RECRUITING NA 38 participants

Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use

Yale University

NCT06171412

RECRUITING NA 36 participants

AIDANET Pediatrics

Mark D. DeBoer, MD, MSc., MCR

NCT07020936

RECRUITING NA 34 participants

To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.

Viral N. Shah

NCT07287943

RECRUITING Phase 4 30 participants

Extended Bolus for Meals in a Closed-loop System

University of California, San Francis

NCT05454891

RECRUITING NA 30 participants

Lipoprotein Kinetics in T1D

University of Missouri-Columbia

NCT05179954

RECRUITING Phase 2 25 participants

Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial

University of California, San Diego

NCT06981234

RECRUITING Phase 1 25 participants

A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500

Portal Diabetes

NCT07341373

RECRUITING Phase 1 24 participants

Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes

University of California, San Diego

NCT05696366

RECRUITING Early Phase 1 24 participants

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Augusta University

NCT04449198

RECRUITING Early Phase 1 24 participants

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

Vanderbilt University Medical Center

NCT06338553

RECRUITING 20 participants

Multivariable Artificial Pancreas: Detecting and Mitigating Unannounced Physical Activity and Acute Psychological Stress

University of Illinois at Chicago

NCT05145374

RECRUITING NA 20 participants

Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D

Mark D. DeBoer, MD, MSc., MCR

NCT06948760

RECRUITING NA 20 participants

BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes

Stanford University

NCT05488119

RECRUITING Phase 1 18 participants

Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes

Creative Medical Technology Holdings

NCT05626712

RECRUITING NA 16 participants

REAL-Fam Feasibility Study for Youth Diabetes Management

University of North Carolina, Chapel Hill

NCT07212790

RECRUITING NA 16 participants

Safety and Feasibility of a Machine-Learning Bolus Priming Added to Existing Control Algorithm

Sue Brown

NCT06728059

RECRUITING NA 15 participants

Resistance Training in Type 1 Diabetes Mellitus

University of Louisville

NCT05315037

RECRUITING Phase 1 13 participants

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Otsuka Pharmaceutical Factory

NCT06575426

RECRUITING Phase 3 10 participants

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

Vertex Pharmaceuticals Incorporated

NCT06832410

RECRUITING NA 10 participants

Closed Loop Context Aware AID

Oregon Health and Science University

NCT06676657

RECRUITING NA 6 participants

Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery

Anas El Fathi

NCT07212179

ACTIVE NOT RECRUITING Phase 3 905 participants

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06914895

ACTIVE NOT RECRUITING 533 participants

Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes

Joslin Diabetes Center

NCT04595474

ACTIVE NOT RECRUITING Phase 3 465 participants

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06962280

ACTIVE NOT RECRUITING NA 280 participants

FAMS-T1D Self-Regulation and Social Support for T1D

University of Utah

NCT05820477

ACTIVE NOT RECRUITING NA 280 participants

Multi-Site Eating Disorder Prevention Program for Type 1 Diabetes

Oslo University Hospital

NCT05399446

ACTIVE NOT RECRUITING NA 195 participants

iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes

University Hospitals Cleveland Medical Center

NCT06348160

ACTIVE NOT RECRUITING NA 144 participants

Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes

University of Illinois at Chicago

NCT04506151

ACTIVE NOT RECRUITING 144 participants

PS230005 Control-IQ 1.5 Post-Approval Study

Tandem Diabetes Care

NCT06717451

ACTIVE NOT RECRUITING NA 140 participants

Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes

Vanderbilt University Medical Center

NCT05854069

ACTIVE NOT RECRUITING NA 109 participants

Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes

Virginia Commonwealth University

NCT05639088

ACTIVE NOT RECRUITING NA 80 participants

Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes

Children's Mercy Hospital Kansas City

NCT06412601

ACTIVE NOT RECRUITING NA 60 participants

Research on Optimizing the Use of Technology With Education

Children's National Research Institute

NCT05564481

ACTIVE NOT RECRUITING Phase 2 60 participants

Reducing Innate Inflammation in New Onset Type 1 Diabetes

Medical College of Wisconsin

NCT04335656

ACTIVE NOT RECRUITING NA 50 participants

The T1D Parent Check-In: A Preventative Intervention

Massachusetts General Hospital

NCT06160934

ACTIVE NOT RECRUITING NA 45 participants

Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care

Massachusetts General Hospital

NCT05229718

ACTIVE NOT RECRUITING Phase 2 43 participants

Probiotics in Newly Diagnosed T1D

Medical College of Wisconsin

NCT04141761

ACTIVE NOT RECRUITING Phase 3 40 participants

A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients

Northwestern University

NCT01897688

ACTIVE NOT RECRUITING NA 36 participants

Fully Closed Loop At Home (FCL@Home)

University of Colorado, Denver

NCT06041971

ACTIVE NOT RECRUITING 34 participants

Evaluating the InPen in Pediatric Type 1 Diabetes

Wayne State University

NCT05515939

ACTIVE NOT RECRUITING NA 32 participants

Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes

Case Western Reserve University

NCT07084805

ACTIVE NOT RECRUITING Phase 2 30 participants

Effects of GRA in Patients With Type 1

University of California, San Diego

NCT04779645

ACTIVE NOT RECRUITING 28 participants

Development of Novel Biomarkers for the Early Diagnosis of Type 1 Diabetes

AdventHealth Translational Research Institute

NCT04164966

ACTIVE NOT RECRUITING NA 28 participants

Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes

Children's Hospital of Philadelphia

NCT04238949

ACTIVE NOT RECRUITING NA 20 participants

A 12-week Pilot Nutrition Intervention for Children With New Diagnosis of Stage 3 Type 1 Diabetes (T1D)

Milton S. Hershey Medical Center

NCT06640478

ACTIVE NOT RECRUITING Phase 1 7 participants

A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes

Vertex Pharmaceuticals Incorporated

NCT05791201

COMPLETED NA 32,796 participants

Extension for Community Health Outcomes (ECHO) Diabetes Program

University of Florida

NCT06552923

COMPLETED Phase 1 1,298 participants

Family Management of Childhood Diabetes Study

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00340938

COMPLETED Phase 3 692 participants

A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Eli Lilly and Company

NCT05463744

COMPLETED 649 participants

A 2-Month Safety Follow-Up Trial

Mannkind Corporation

NCT00741429

COMPLETED NA 568 participants

Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)

University of Virginia

NCT01563887

COMPLETED NA 485 participants

Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy

Medtronic Diabetes

NCT00417989

Phase Distribution

PhaseTrial count
Early Phase 1 27
Phase 2 23
Phase 3 10
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 1 Diabetes Trial Landscape

ClinicalTrials.gov lists 179 US studies indexed under Type 1 Diabetes, and 69 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Type 1 Diabetes shows 19 late-stage studies (Phase 3 and Phase 4 combined) alongside 50 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Type 1 Diabetes is led by University of Colorado, Denver with 14 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 1 Diabetes?

PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 1 Diabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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