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Type 1 Diabetes
Open-data reference.
179 US clinical trials · 69 currently recruiting
Active & Recent Trials
The T1D Exchange Registry
T1D Exchange, United States
NCT04629586
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
Sanford Health
NCT04477928
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
University of Colorado, Denver
NCT06141434
Immune Function and the Progression to T1D
University of Florida
NCT05899439
Post Market Registry for the Omnipod 5 System in Children and Adults With Type 1 Diabetes
Insulet Corporation
NCT06144554
The iLet Experience Study
Beta Bionics
NCT06891898
Commercial or Open Source Closed Loop Impact on Pregnancy Study
University of California, San Francis
NCT06654713
A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States
Sanofi
NCT07260110
ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2
Johns Hopkins University
NCT05463289
EMPoWER Study - Strengths-based Behavioral Intervention for Youth With Type 1 Diabetes
Baylor College of Medicine
NCT06014879
ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes
Scripps Whittier Diabetes Institute
NCT04933851
Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes
Duke University
NCT05540704
Family Intervention for Black Teens With Type 1 Diabetes
Wayne State University
NCT06275412
Accessing Care, Clinical Trials and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D)
AdventHealth Translational Research Institute
NCT06908057
Registry for Stage 2 Type 1 Diabetes
Sanofi
NCT06481904
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
Nemours Children's Clinic
NCT05268250
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
SAb Biotherapeutics
NCT07187531
Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes
University of Colorado, Denver
NCT06297980
Sleep Coach for Adolescents With Type 1 Diabetes
Vanderbilt University Medical Center
NCT06516614
Discovery Diabetes
Vanderbilt University Medical Center
NCT07116434
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
NYU Langone Health
NCT05641753
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
City of Hope Medical Center
NCT07061574
Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes
University of Colorado, Denver
NCT06575842
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Heba M. Ismail
NCT05414409
A Study Comparing Dexcom Continuous Glucose Monitoring to Point of Care Glucose Testing for the Management of Hospital and Post-Discharge Subjects With Type 1 Diabetes
Emory University
NCT06752928
Pathogenesis of Kidney Disease in Type 1 Diabetes: a Modern Kidney Biopsy Cohort (The PANDA Study)
University of Colorado, Denver
NCT05319990
T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes
Yale University
NCT07059806
Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years
Massachusetts General Hospital
NCT05866536
InvesT1D: Promoting Adolescent Investment in Diabetes Care
Harvard Pilgrim Health Care
NCT06384911
Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression
Albert Einstein College of Medicine
NCT05734313
Reducing Diabetes Distress Using Cognitive Behavioral Therapy in Young Adults With Type 1 Diabetes
Albert Einstein College of Medicine
NCT05000021
Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk
Creighton University
NCT05701254
Transdisciplinary Care for Young Adults With Type 1 Diabetes
Nemours Children's Clinic
NCT06172166
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company
NCT06783309
TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
Emily K. Sims
NCT05594563
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Kalie Tommerdahl
NCT05065372
Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
University of Florida
NCT06455319
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
University of Washington
NCT05822609
Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening
Yale University
NCT07155252
The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
Mayo Clinic
NCT06976619
GO TEAM: Glucose Optimization Through Technology Assisted Management
Sarah MacLeish
NCT06074458
Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes
Throne Biotechnologies
NCT04011020
Denosumab for Type 1 Diabetes
City of Hope Medical Center
NCT06524960
AIDANET At Home Study
Sue Brown
NCT07039617
Expansion of the T1DES Pilot to a Public Hospital
Kaiser Permanente
NCT06494722
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
University of Virginia
NCT05653518
Using Simplified Meal Boluses Versus Carbohydrate Counting in Adolescents With Hybrid Closed Loop Systems
University of Colorado, Denver
NCT06575790
Effect of C-peptide on Hypoglycemic Counterregulation
University of Cincinnati
NCT06470295
Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use
Yale University
NCT06171412
AIDANET Pediatrics
Mark D. DeBoer, MD, MSc., MCR
NCT07020936
To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.
Viral N. Shah
NCT07287943
Extended Bolus for Meals in a Closed-loop System
University of California, San Francis
NCT05454891
Lipoprotein Kinetics in T1D
University of Missouri-Columbia
NCT05179954
Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
University of California, San Diego
NCT06981234
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Portal Diabetes
NCT07341373
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
University of California, San Diego
NCT05696366
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Augusta University
NCT04449198
GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab
Vanderbilt University Medical Center
NCT06338553
Multivariable Artificial Pancreas: Detecting and Mitigating Unannounced Physical Activity and Acute Psychological Stress
University of Illinois at Chicago
NCT05145374
Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D
Mark D. DeBoer, MD, MSc., MCR
NCT06948760
BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes
Stanford University
NCT05488119
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings
NCT05626712
REAL-Fam Feasibility Study for Youth Diabetes Management
University of North Carolina, Chapel Hill
NCT07212790
Safety and Feasibility of a Machine-Learning Bolus Priming Added to Existing Control Algorithm
Sue Brown
NCT06728059
Resistance Training in Type 1 Diabetes Mellitus
University of Louisville
NCT05315037
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
Vertex Pharmaceuticals Incorporated
NCT06832410
Closed Loop Context Aware AID
Oregon Health and Science University
NCT06676657
Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery
Anas El Fathi
NCT07212179
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06914895
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes
Joslin Diabetes Center
NCT04595474
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06962280
FAMS-T1D Self-Regulation and Social Support for T1D
University of Utah
NCT05820477
Multi-Site Eating Disorder Prevention Program for Type 1 Diabetes
Oslo University Hospital
NCT05399446
iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes
University Hospitals Cleveland Medical Center
NCT06348160
Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes
University of Illinois at Chicago
NCT04506151
PS230005 Control-IQ 1.5 Post-Approval Study
Tandem Diabetes Care
NCT06717451
Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes
Vanderbilt University Medical Center
NCT05854069
Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes
Virginia Commonwealth University
NCT05639088
Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes
Children's Mercy Hospital Kansas City
NCT06412601
Research on Optimizing the Use of Technology With Education
Children's National Research Institute
NCT05564481
Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin
NCT04335656
The T1D Parent Check-In: A Preventative Intervention
Massachusetts General Hospital
NCT06160934
Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care
Massachusetts General Hospital
NCT05229718
Probiotics in Newly Diagnosed T1D
Medical College of Wisconsin
NCT04141761
A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients
Northwestern University
NCT01897688
Fully Closed Loop At Home (FCL@Home)
University of Colorado, Denver
NCT06041971
Evaluating the InPen in Pediatric Type 1 Diabetes
Wayne State University
NCT05515939
Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes
Case Western Reserve University
NCT07084805
Effects of GRA in Patients With Type 1
University of California, San Diego
NCT04779645
Development of Novel Biomarkers for the Early Diagnosis of Type 1 Diabetes
AdventHealth Translational Research Institute
NCT04164966
Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes
Children's Hospital of Philadelphia
NCT04238949
A 12-week Pilot Nutrition Intervention for Children With New Diagnosis of Stage 3 Type 1 Diabetes (T1D)
Milton S. Hershey Medical Center
NCT06640478
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
NCT05791201
Extension for Community Health Outcomes (ECHO) Diabetes Program
University of Florida
NCT06552923
Family Management of Childhood Diabetes Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00340938
A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy
Eli Lilly and Company
NCT05463744
A 2-Month Safety Follow-Up Trial
Mannkind Corporation
NCT00741429
Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)
University of Virginia
NCT01563887
Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy
Medtronic Diabetes
NCT00417989
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 27 |
| Phase 2 | 23 |
| Phase 3 | 10 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Trial Landscape
ClinicalTrials.gov lists 179 US studies indexed under Type 1 Diabetes, and 69 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Type 1 Diabetes shows 19 late-stage studies (Phase 3 and Phase 4 combined) alongside 50 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Type 1 Diabetes is led by University of Colorado, Denver with 14 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes?
PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.