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ClinicalTrials.gov 69 recruiting now official registry

Type 1 Diabetes clinical trials

69 of 179 indexed Type 1 Diabetes trials are currently recruiting.

179 US clinical trials · 69 currently recruiting

Type 1 Diabetes is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 69 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 14 of these trials.

The research picture

Type 1 Diabetes has 179 registered US clinical trials, 69 of them open to new participants right now, about 39% of the total.

69
recruiting participants now
39%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
14
top sponsor: University of Colorado, Denver
Phase 127Phase 223Phase 310Phase 49

Active & Recent Trials

179 total, page 1 of 4

RECRUITING 50,000 participants

The T1D Exchange Registry

T1D Exchange, United States

NCT04629586

RECRUITING 33,000 participants

General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery

Sanford Health

NCT04477928

RECRUITING 6,000 participants

PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life

University of Colorado, Denver

NCT06141434

RECRUITING 2,800 participants

Immune Function and the Progression to T1D

University of Florida

NCT05899439

RECRUITING 2,200 participants

Post Market Registry for the Omnipod 5 System in Children and Adults With Type 1 Diabetes

Insulet Corporation

NCT06144554

RECRUITING 1,875 participants

The iLet Experience Study

Beta Bionics

NCT06891898

RECRUITING 1,000 participants

Commercial or Open Source Closed Loop Impact on Pregnancy Study

University of California, San Francisco

NCT06654713

RECRUITING 550 participants

A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States

Sanofi

NCT07260110

RECRUITING NA 500 participants

ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2

Johns Hopkins University

NCT05463289

RECRUITING NA 250 participants

EMPoWER Study - Strengths-based Behavioral Intervention for Youth With Type 1 Diabetes

Baylor College of Medicine

NCT06014879

RECRUITING Phase 2 250 participants

ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes

Scripps Whittier Diabetes Institute

NCT04933851

RECRUITING NA 235 participants

Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

Duke University

NCT05540704

RECRUITING NA 216 participants

Family Intervention for Black Teens With Type 1 Diabetes

Wayne State University

NCT06275412

RECRUITING 200 participants

Accessing Care, Clinical Trials and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D)

AdventHealth Translational Research Institute

NCT06908057

RECRUITING 200 participants

Registry for Stage 2 Type 1 Diabetes

Sanofi

NCT06481904

RECRUITING NA 180 participants

Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

Nemours Children's Clinic

NCT05268250

RECRUITING Phase 2 159 participants

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

SAb Biotherapeutics

NCT07187531

RECRUITING NA 150 participants

Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes

University of Colorado, Denver

NCT06297980

RECRUITING NA 150 participants

Sleep Coach for Adolescents With Type 1 Diabetes

Vanderbilt University Medical Center

NCT06516614

RECRUITING NA 150 participants

Discovery Diabetes

Vanderbilt University Medical Center

NCT07116434

RECRUITING Phase 4 125 participants

Cholesterol Lowering and Residual Risk in Diabetes, Type 1

NYU Langone Health

NCT05641753

RECRUITING Phase 1 120 participants

A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes

City of Hope Medical Center

NCT07061574

RECRUITING 120 participants

Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes

University of Colorado, Denver

NCT06575842

RECRUITING Phase 2 114 participants

The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

Heba M. Ismail

NCT05414409

RECRUITING NA 100 participants

A Study Comparing Dexcom Continuous Glucose Monitoring to Point of Care Glucose Testing for the Management of Hospital and Post-Discharge Subjects With Type 1 Diabetes

Emory University

NCT06752928

RECRUITING 100 participants

Pathogenesis of Kidney Disease in Type 1 Diabetes: a Modern Kidney Biopsy Cohort (The PANDA Study)

University of Colorado, Denver

NCT05319990

RECRUITING NA 100 participants

T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes

Yale University

NCT07059806

RECRUITING Phase 2 100 participants

Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years

Massachusetts General Hospital

NCT05866536

RECRUITING NA 96 participants

InvesT1D: Promoting Adolescent Investment in Diabetes Care

Harvard Pilgrim Health Care

NCT06384911

RECRUITING NA 94 participants

Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

Albert Einstein College of Medicine

NCT05734313

RECRUITING NA 93 participants

Reducing Diabetes Distress Using Cognitive Behavioral Therapy in Young Adults With Type 1 Diabetes

Albert Einstein College of Medicine

NCT05000021

RECRUITING 80 participants

Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk

Creighton University

NCT05701254

RECRUITING NA 80 participants

Transdisciplinary Care for Young Adults With Type 1 Diabetes

Nemours Children's Clinic

NCT06172166

RECRUITING Phase 1 72 participants

CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

COUR Pharmaceutical Development Company

NCT06783309

RECRUITING Phase 2 70 participants

TArgeting Type 1 Diabetes Using POLyamines (TADPOL)

Emily K. Sims

NCT05594563

RECRUITING Phase 1 60 participants

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

Kalie Tommerdahl

NCT05065372

RECRUITING Phase 2 60 participants

Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

University of Florida

NCT06455319

RECRUITING Phase 2 60 participants

Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

University of Washington

NCT05822609

RECRUITING 60 participants

Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening

Yale University

NCT07155252

RECRUITING Phase 2 60 participants

The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

Mayo Clinic

NCT06976619

RECRUITING NA 60 participants

GO TEAM: Glucose Optimization Through Technology Assisted Management

Sarah MacLeish

NCT06074458

RECRUITING Phase 2 50 participants

Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes

Throne Biotechnologies

NCT04011020

RECRUITING Phase 1 45 participants

Denosumab for Type 1 Diabetes

City of Hope Medical Center

NCT06524960

RECRUITING NA 40 participants

AIDANET At Home Study

Sue Brown

NCT07039617

RECRUITING NA 40 participants

Expansion of the T1DES Pilot to a Public Hospital

Kaiser Permanente

NCT06494722

RECRUITING NA 40 participants

Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes

University of Virginia

NCT05653518

RECRUITING NA 40 participants

Using Simplified Meal Boluses Versus Carbohydrate Counting in Adolescents With Hybrid Closed Loop Systems

University of Colorado, Denver

NCT06575790

RECRUITING Early Phase 1 38 participants

Effect of C-peptide on Hypoglycemic Counterregulation

University of Cincinnati

NCT06470295

RECRUITING NA 38 participants

Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use

Yale University

NCT06171412

RECRUITING NA 36 participants

AIDANET Pediatrics

Mark D. DeBoer, MD, MSc., MCR

NCT07020936

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Phase Distribution

PhaseTrial count
Phase 1 27
Phase 2 23
Phase 3 10
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 1 Diabetes Trial Landscape

179 indexed Type 1 Diabetes studies · 69 recruiting (39%).

Phase mix: 19 late (III/IV) vs 50 early (I/II).

Top sponsor: University of Colorado, Denver (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 1 Diabetes?

PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 1 Diabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.