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COMPLETED Phase 3

A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

NCT05872620 · View on ClinicalTrials.gov ↗

Study Summary

This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes. The study will last about 77 weeks and may include up to 22 visits.

Interventions

  • DRUG Placebo
  • DRUG Orforglipron

Study Locations (20)

California

  • AMCR Institute — Escondido
  • Velocity Clinical Research, Huntington Park — Huntington Park
  • Velocity Clinical Research, Westlake — Los Angeles
  • Catalina Research Institute, LLC — Montclair
  • University Clinical Investigators, Inc. — Tustin

Florida

  • Encore Medical Research — Hollywood
  • East Coast Institute for Research, LLC — Jacksonville
  • South Florida Clinical Research Institute — Margate
  • Suncoast Clinical Research, Inc. — New Port Richey

Georgia

  • Balanced Life Health Care Solutions/SKYCRNG — Lawrenceville
  • Endocrine Research Solutions, Inc. — Roswell
  • North Georgia Clinical Research — Woodstock

Arizona

  • Novak Clinical Research - Tucson - North La Cholla Boulevard — Tucson
  • Yuma Clinical Trials — Yuma

Alabama

  • Cahaba Research - Pelham — Pelham

Hawaii

  • Pacific Diabetes & Endocrine Center — Honolulu

Idaho

  • Solaris Clinical Research — Meridian

Iowa

  • Iowa Diabetes and Endocrinology Research Center — West Des Moines

Trial Details

FieldValue
Enrollment Target 1,613 participants
Start Date 2023-06-05
Est. Completion 2025-08-08
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05872620

The ClinicalTrials.gov registry entry for NCT05872620 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,613 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05872620 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05872620 about?

NCT05872620 is a clinical study titled "A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes". This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult participants with obesity or overweight and type 2 diabetes. The study will last about 77 weeks and may include up to 22 visits.

What is the current status of trial NCT05872620?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 1,613 participants. The study started on 2023-06-05. Estimated completion is 2025-08-08.

What conditions does trial NCT05872620 study?

This clinical trial studies the following conditions: Obesity, Type 2 Diabetes, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05872620?

The interventions under investigation include: Placebo (DRUG), Orforglipron (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05872620?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05872620 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial