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ACTIVE NOT RECRUITING Phase 2

A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

NCT07281937 · View on ClinicalTrials.gov ↗

Study Summary

The aim of this study is to evaluate the efficacy of VRB-101 for body weight reduction compared to placebo in participants who have obesity or overweight with weight-related comorbidities.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG VRB-101

Study Locations (20)

California

  • Clinical Study Site 111 — Anaheim
  • Clinical Study Site 107 — Montclair
  • Clinical Study Site 118 — Tarzana

Alabama

  • Clinical Study Site 103 — Anniston
  • Clinical Study Site 109 — Cullman

New York

  • Clinical Study Site 117 — Binghamton
  • Clinical Study Site 101 — Rochester

North Carolina

  • Clinical Study Site 120 — Charlotte
  • Clinical Study Site 108 — Monroe

Arizona

  • Clinical Study Site 110 — Phoenix

Arkansas

  • Clinical Study Site 113 — Little Rock

Georgia

  • Clinical Study Site 119 — Decatur

Iowa

  • Clinical Study Site 116 — West Des Moines

Trial Details

FieldValue
Enrollment Target 206 participants
Start Date 2025-11-25
Est. Completion 2026-08
Phase Phase 2

Sponsor

Verdiva Bio Dev Limited

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07281937

The ClinicalTrials.gov registry entry for NCT07281937 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 206 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Verdiva Bio Dev Limited, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07281937 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Alabama, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07281937 about?

NCT07281937 is a clinical study titled "A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities". The aim of this study is to evaluate the efficacy of VRB-101 for body weight reduction compared to placebo in participants who have obesity or overweight with weight-related comorbidities.

What is the current status of trial NCT07281937?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 206 participants. The study started on 2025-11-25. Estimated completion is 2026-08.

What conditions does trial NCT07281937 study?

This clinical trial studies the following conditions: Obesity, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07281937?

The interventions under investigation include: Placebo (DRUG), VRB-101 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07281937?

This trial is sponsored by Verdiva Bio Dev Limited, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07281937 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial