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ACTIVE NOT RECRUITING Phase 3

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

NCT05556512 · View on ClinicalTrials.gov ↗

Study Summary

This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Tirzepatide

Study Locations (20)

California

  • Smart Cures Clinical Research — Anaheim
  • Kidney & Hypertension Center - Apple Valley — Apple Valley
  • Hope Clinical Research, Inc. — Canoga Park
  • John Muir Physician Network Research Center — Concord
  • Neighborhood Healthcare Institute of Health — Escondido
  • HB Clinical Trials - Fountain Valley — Fountain Valley
  • Valiance Clinical Research — Huntington Park
  • Scripps Whittier Diabetes Institute — La Jolla
  • Velocity Clinical Research, San Diego — La Mesa
  • First Valley Medical Group — Lancaster
  • Long Beach Clinical Trials — Long Beach
  • Infinity Clinical Research - Norco — Norco
  • California Medical Research Associates — Northridge
  • Diabetes Associates Medical Group — Orange
  • University of California Irvine Medical Center — Orange

Arizona

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC — Gilbert
  • Aventiv Research — Mesa
  • Elite Clinical Studies — Phoenix
  • Pima Heart — Tucson

Arkansas

  • KLR Business Group, Inc. dba Arkansas Clinical Research — Little Rock

Trial Details

FieldValue
Enrollment Target 15,374 participants
Start Date 2022-10-11
Est. Completion 2027-10
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05556512

The ClinicalTrials.gov registry entry for NCT05556512 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 15,374 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05556512 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Arizona, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05556512 about?

NCT05556512 is a clinical study titled "A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity". This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

What is the current status of trial NCT05556512?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 15,374 participants. The study started on 2022-10-11. Estimated completion is 2027-10.

What conditions does trial NCT05556512 study?

This clinical trial studies the following conditions: Obesity, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05556512?

The interventions under investigation include: Placebo (DRUG), Tirzepatide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05556512?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05556512 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial