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ACTIVE NOT RECRUITING Phase 2

A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight

NCT06643728 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to evaluate the efficacy and safety of Bimagrumab and Tirzepatide, alone or in combination, in adults with obesity or overweight, with at least one obesity related comorbidity, without Type 2 Diabetes. The study will last about 70 weeks.

Conditions Studied

Interventions

  • DRUG Tirzepatide
  • DRUG Bimagrumab
  • DRUG Bimagrumab Placebo
  • DRUG Tirzepatide Placebo

Study Locations (12)

Florida

  • Clinical Neuroscience Solutions, Inc. dba CNS Healthcare — Jacksonville
  • Altus Research — Lake Worth
  • Suncoast Research Group — Miami

Alabama

  • Pinnacle Research Group, LLC — Anniston
  • Central Research Associates — Birmingham

Washington

  • Eastside Research Associates — Redmond
  • Rainier Clinical Research Center — Renton

California

  • Diablo Clinical Research, Inc. — Walnut Creek

Hawaii

  • East-West Medical Research Institute — Honolulu

Illinois

  • Great Lakes Clinical Trials - Ravenswood — Chicago

Mississippi

  • SKY Integrative Medical Center/SKYCRNG — Ridgeland

Pennsylvania

  • Keystone Clinical Studies — Plymouth Meeting

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2024-10-21
Est. Completion 2027-01
Phase Phase 2

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06643728

The ClinicalTrials.gov registry entry for NCT06643728 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 4 interventions — of which Tirzepatide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06643728 reports 12 study locations spanning 8 distinct geographic areas — top geographies include Florida, Alabama, Washington. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06643728 about?

NCT06643728 is a clinical study titled "A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight". The main purpose of this study is to evaluate the efficacy and safety of Bimagrumab and Tirzepatide, alone or in combination, in adults with obesity or overweight, with at least one obesity related comorbidity, without Type 2 Diabetes. The study will last about 70 weeks.

What is the current status of trial NCT06643728?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2024-10-21. Estimated completion is 2027-01.

What conditions does trial NCT06643728 study?

This clinical trial studies the following conditions: Obesity, Overweight. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06643728?

The interventions under investigation include: Tirzepatide (DRUG), Bimagrumab (DRUG), Bimagrumab Placebo (DRUG), Tirzepatide Placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06643728?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06643728 being conducted?

This trial has 12 study locations across Alabama, California, Florida, Hawaii, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial