Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Glioblastoma

Open-data reference.

200 US clinical trials · 78 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 1,280 participants

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Global Coalition for Adaptive Research

NCT03970447

RECRUITING 1,015 participants

The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)

Jasper Gerritsen

NCT06146738

RECRUITING 784 participants

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

Jasper Gerritsen

NCT06118723

RECRUITING Phase 3 766 participants

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

GT Medical Technologies

NCT07195591

RECRUITING Phase 3 741 participants

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

NovoCure

NCT06556563

RECRUITING 564 participants

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)

Jasper Gerritsen

NCT06146725

RECRUITING 464 participants

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

Jasper Gerritsen

NCT06283927

RECRUITING Phase 2 460 participants

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

Patrick Wen, MD

NCT02977780

RECRUITING 453 participants

The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections

Erasmus Medical Center

NCT04708171

RECRUITING Phase 3 450 participants

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Ivy Brain Tumor Center

NCT06388733

RECRUITING Phase 3 432 participants

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Northwell Health

NCT05271240

RECRUITING 350 participants

Targeted Pediatric High-Grade Glioma Therapy

Nationwide Children's Hospital

NCT05839379

RECRUITING 225 participants

The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma

Erasmus Medical Center

NCT06273176

RECRUITING Phase 1 208 participants

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

Sabine Mueller, MD, PhD

NCT04732065

RECRUITING 200 participants

Key Longitudinal Associations With Risk and Glioblastoma Outcomes

Duke University

NCT06625684

RECRUITING Phase 2 190 participants

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Baptist Health South Florida

NCT06991101

RECRUITING NA 149 participants

Serial MRI Scans During Radiation Therapy

Dana-Farber Cancer Institute

NCT04188535

RECRUITING Phase 1 146 participants

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

National Cancer Institute (NCI)

NCT06161519

RECRUITING Phase 1 134 participants

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

RasCal Therapeutics

NCT04678648

RECRUITING Phase 2 120 participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Nationwide Children's Hospital

NCT05843253

RECRUITING 120 participants

Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue

Baptist Health South Florida

NCT05756985

RECRUITING NA 117 participants

Customized Neuro-Imaging Referenced Symptom Video for the Reduction of Patient and Caregiver Anxiety Around Radiation Treatment for Brain Tumors

M.D. Anderson Cancer Center

NCT04479696

RECRUITING Phase 2 103 participants

Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma

Alpheus Medical

NCT07225621

RECRUITING Phase 1 102 participants

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Jazz Pharmaceuticals

NCT04541082

RECRUITING NA 100 participants

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Mayo Clinic

NCT04047264

RECRUITING Phase 1 94 participants

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

Mayo Clinic

NCT05917145

RECRUITING Phase 2 90 participants

A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence

Philogen S.p.A.

NCT06336291

RECRUITING Early Phase 1 82 participants

A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions

St. Joseph's Hospital and Medical Center, Phoenix

NCT06072586

RECRUITING Phase 2 78 participants

Surgical Pembro +/- Olaparib w TMZ for rGBM

L. Nicolas Gonzalez Castro, MD, PhD

NCT05463848

RECRUITING Phase 1 67 participants

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

Northwell Health

NCT03213002

RECRUITING Phase 1 66 participants

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Orbus Therapeutics

NCT05879367

RECRUITING Phase 1 62 participants

HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

The Methodist Hospital Research Institute

NCT03603405

RECRUITING Phase 1 60 participants

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Memorial Sloan Kettering Cancer Center

NCT06934889

RECRUITING Phase 1 56 participants

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

Dana-Farber Cancer Institute

NCT02287428

RECRUITING NA 50 participants

Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma

Jonsson Comprehensive Cancer Center

NCT06090903

RECRUITING Phase 2 48 participants

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

Case Comprehensive Cancer Center

NCT07003542

RECRUITING Phase 1 48 participants

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

St. Jude Children's Research Hospital

NCT05835687

RECRUITING Phase 1 48 participants

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Orano Med

NCT05283330

RECRUITING Phase 1 48 participants

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

Nicholas Butowski

NCT05557292

RECRUITING Phase 1 45 participants

A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma

M.D. Anderson Cancer Center

NCT06672575

RECRUITING Phase 2 40 participants

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

M.D. Anderson Cancer Center

NCT04623931

RECRUITING Phase 2 40 participants

Venous Thromboembolism Prevention in Outpatients With Glioma

University of Vermont Medical Center

NCT05683808

RECRUITING NA 40 participants

Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma

Washington University School of Medicine

NCT05281731

RECRUITING Phase 2 37 participants

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Northwell Health

NCT02800486

RECRUITING Phase 1 37 participants

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Theodore S. Johnson

NCT05106296

RECRUITING Phase 2 34 participants

N-803 and PD-L1 t-haNK Combined With Bevacizumab for Recurrent or Progressive Glioblastoma

ImmunityBio

NCT06061809

RECRUITING Phase 1 33 participants

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Northwell Health

NCT02861898

RECRUITING NA 32 participants

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

University of Maryland, Baltimore

NCT04699773

RECRUITING NA 32 participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

University of Maryland, Baltimore

NCT04181684

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING NA 30 participants

Evaluation of the CONVIVO System

Dartmouth-Hitchcock Medical Center

NCT05139277

RECRUITING Phase 2 30 participants

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center

NCT06058988

RECRUITING Phase 1 30 participants

Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas

SignPath Pharma

NCT05768919

RECRUITING Phase 1 29 participants

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

M.D. Anderson Cancer Center

NCT04555577

RECRUITING Early Phase 1 27 participants

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Ugonma Chukwueke

NCT06552260

RECRUITING NA 25 participants

Glioblastoma Remote Monitoring and Care - Research Protocol

Case Comprehensive Cancer Center

NCT06129760

RECRUITING Phase 2 25 participants

Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma

The University of Texas Health Science Center at San Antonio

NCT04863950

RECRUITING Phase 1 24 participants

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

University of Nebraska

NCT05698524

RECRUITING Phase 1 24 participants

Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma

Emory University

NCT04590664

RECRUITING Phase 1 21 participants

CARv3-TEAM-E T Cells in Glioblastoma

Marcela V. Maus, M.D.,Ph.D.

NCT05660369

RECRUITING 20 participants

NovoTTF Treatment Signatures in Glioblastoma Patients At Autopsy

Medical College of Wisconsin

NCT03194971

RECRUITING NA 20 participants

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Columbia University

NCT06108206

RECRUITING Phase 1 20 participants

Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma

University of California, Davis

NCT07145112

RECRUITING Phase 1 20 participants

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Sabine Mueller, MD, PhD

NCT04323046

RECRUITING Phase 1 20 participants

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Hideho Okada, MD, PhD

NCT06186401

RECRUITING Phase 2 19 participants

Methimazole in Patients With Progressive Glioblastoma

Case Comprehensive Cancer Center

NCT05607407

RECRUITING Phase 1 18 participants

CUE-102 in Recurrent Glioblastoma

David Reardon, MD

NCT06917885

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 1 18 participants

PH Sensitive MRI Based Resections of Glioblastoma

University of California, Los Angeles

NCT06176066

RECRUITING Early Phase 1 15 participants

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

NCT06333899

RECRUITING Phase 3 15 participants

Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients

Jonsson Comprehensive Cancer Center

NCT07461948

RECRUITING Early Phase 1 15 participants

Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

Abramson Cancer Center at Penn Medicine

NCT06613841

RECRUITING Early Phase 1 12 participants

Implantable Microdevice In Primary Brain Tumors

Oliver Jonas

NCT04135807

RECRUITING Early Phase 1 12 participants

Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma

Washington University School of Medicine

NCT06831526

RECRUITING Early Phase 1 12 participants

Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG

Nader Sanai

NCT05773326

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

RECRUITING Phase 1 10 participants

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Case Comprehensive Cancer Center

NCT05565118

RECRUITING Phase 1 9 participants

CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy

University of Pennsylvania

NCT06973096

ACTIVE NOT RECRUITING Phase 2 606 participants

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

NRG Oncology

NCT02179086

ACTIVE NOT RECRUITING Phase 3 560 participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

CarThera

NCT05902169

ACTIVE NOT RECRUITING Phase 2 447 participants

Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT02152982

ACTIVE NOT RECRUITING Phase 3 314 participants

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Universitätsmedizin Mannheim

NCT02685605

ACTIVE NOT RECRUITING 309 participants

Coping With Glioblastoma: A Study of Communication Between Physicians, Patients, and Caregivers

Memorial Sloan Kettering Cancer Center

NCT02375841

ACTIVE NOT RECRUITING Phase 3 265 participants

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

NRG Oncology

NCT05095376

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 2 170 participants

Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study

Mayo Clinic

NCT05781321

ACTIVE NOT RECRUITING Phase 4 163 participants

Pediatric Long-Term Follow-up and Rollover Study

Novartis Pharmaceuticals

NCT03975829

ACTIVE NOT RECRUITING Phase 1 150 participants

Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

Nerviano Medical Sciences

NCT04910022

ACTIVE NOT RECRUITING Phase 2 130 participants

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Theodore S. Johnson

NCT04049669

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING NA 100 participants

Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT03251027

ACTIVE NOT RECRUITING Early Phase 1 97 participants

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Nader Sanai

NCT05182905

ACTIVE NOT RECRUITING Phase 2 93 participants

A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma

Imvax

NCT04485949

ACTIVE NOT RECRUITING Phase 2 90 participants

Nivolumab Plus Standard Dose Bevacizumab Versus Nivolumab Plus Low Dose Bevacizumab in GBM

David Peereboom

NCT03452579

ACTIVE NOT RECRUITING Phase 2 89 participants

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

National Cancer Institute (NCI)

NCT03212274

ACTIVE NOT RECRUITING Phase 2 84 participants

ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme

Epitopoietic Research Corporation

NCT01903330

ACTIVE NOT RECRUITING Phase 1 78 participants

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

University of California, San Francis

NCT03749187

ACTIVE NOT RECRUITING NA 74 participants

Mind-Body Intervention in Glioma Couples

M.D. Anderson Cancer Center

NCT03244995

ACTIVE NOT RECRUITING Phase 1 67 participants

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM

University of Pennsylvania

NCT05168423

ACTIVE NOT RECRUITING Phase 2 66 participants

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Roswell Park Cancer Institute

NCT02455557

Phase Distribution

PhaseTrial count
Early Phase 1 87
Phase 2 61
Phase 3 13
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Trial Landscape

ClinicalTrials.gov lists 200 US studies indexed under Glioblastoma, and 78 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Glioblastoma shows 15 late-stage studies (Phase 3 and Phase 4 combined) alongside 148 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Glioblastoma is led by National Cancer Institute (NCI) with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma?

PlainTrial tracks 200 US clinical trials for Glioblastoma, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →