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Osteoporosis clinical trials
11 of 87 indexed Osteoporosis trials are currently recruiting.
87 US clinical trials · 11 currently recruiting
Osteoporosis is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 4 of these trials.
The research picture
Osteoporosis has 87 registered US clinical trials, 11 of them open to new participants right now, about 13% of the total.
- 11
- recruiting participants now
- 13%
- of trials open to enrollment
- 28
- in Phase 3–4 (later-stage)
- 4
- top sponsor: University of Colorado, Denver
Active & Recent Trials
87 total, page 1 of 2
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
University of Alabama at Birmingham
NCT06455085
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
Johns Hopkins University
NCT05845021
OsteoPorotic fracTure preventION System (OPTIONS) Research Study
Brigham and Women's Hospital
NCT06731608
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
AO Foundation, AO Spine
NCT07027306
Synbiotic to Attenuate Resorption of the Skeleton
Hebrew SeniorLife
NCT06389539
Preserving Geriatric Muscle With an Osteoporosis Medication
Susan L. Greenspan
NCT06118905
Mode of Exercise and Bone Biomarkers in Older Veterans
VA Office of Research and Development
NCT05266976
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Bettina Mittendorfer
NCT07083557
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
University of Texas Southwestern Medical Center
NCT05998863
Combined Anabolic Therapy
Massachusetts General Hospital
NCT06558188
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
Duke University
NCT06041789
Trial of Parkinson's And Zoledronic Acid
California Pacific Medical Center Research Institute
NCT03924414
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
Beth Israel Deaconess Medical Center
NCT03076034
Romosozumab Use to Build Skeletal Integrity
Susan L. Greenspan
NCT05058976
Sickle Cell Disease (SCD) Bone Pain Study
University of California, Davis
NCT05283148
Comparative Antiresorptive Efficacy Discontinuation of Denosumab
Massachusetts General Hospital
NCT03623633
Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study
University of Alabama at Birmingham
NCT04177940
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
James J. Peters Veterans Affairs Medical Center
NCT05101018
Skeletal Effects of Chronic Night Shift
University of Colorado, Denver
NCT05091021
Muscle Impact of Treating Osteoporosis
Nami Safai Haeri
NCT05666310
A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis
Memorial Sloan Kettering Cancer Center
NCT05775094
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
VA Office of Research and Development
NCT01446705
Patient- and Physician-Based Osteoporosis Education
Brigham and Women's Hospital
NCT00073190
HORIZON-PFT: Pivotal Fracture Trial
Novartis Pharmaceuticals
NCT00049829
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
University of Alabama at Birmingham
NCT01378689
Improving Quality With Outpatient Decision Support
Agency for Healthcare Research and Quality (AHRQ)
NCT00225628
Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)
Novartis
NCT00145327
Ultrarunners Longitudinal TRAcking Study (ULTRA)
Stanford University
NCT02014038
Open Label Extension Study of PREOS
Shire
NCT00172133
Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy
GTx
NCT00129142
Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women
Pfizer
NCT00242710
Yoga in the Treatment of Osteoporosis
Manhattan Physical Medicine and Rehabilitation
NCT02399176
Age Dependend Diagnostic Thresholds for Osteoporosis Bindex Ultrasonometer
Bone Index Finland
NCT01978834
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
Punam K Saha
NCT03534934
Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification
National Institute on Aging (NIA)
NCT00183001
A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00069004
Effect of Calcium and Vitamin D on Bone Loss From the Hip
Tufts University
NCT00357643
Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer
Alliance for Clinical Trials in Oncology
NCT00022087
Comparison of Teriparatide With Alendronate for Treating Glucocorticoid-Induced Osteoporosis
Eli Lilly and Company
NCT00051558
Calcium and Bone Mass in Young Females
Ohio State University
NCT00000402
Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs
Medtronic Spinal and Biologics
NCT01871519
Osteoporosis Prevention in Preadolescent Girls
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00000413
GIOP Prevention Among People With Rheumatoid Arthritis
University of North Carolina, Chapel Hill
NCT00609830
Adding Phosphorus to Osteoporosis Drug Treatment
Creighton University
NCT00074711
Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00067600
A Comparison of PF708 and Forteo in Osteoporosis Patients
Pfenex
NCT03002428
Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density
Novartis
NCT00431444
Comparison Study of PTHrP and PTH to Treat Osteoporosis
University of Pittsburgh
NCT00853723
Effects of DHEA/Exercise on Bone, Muscle and Balance
National Aeronautics and Space Administration (NASA)
NCT00664053
Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects
Warner Chilcott
NCT00699777
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 10 |
| Phase 3 | 12 |
| Phase 4 | 16 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteoporosis Trial Landscape
87 indexed Osteoporosis studies · 11 recruiting (13%).
Phase mix: 28 late (III/IV) vs 21 early (I/II).
Top sponsor: University of Colorado, Denver (4 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteoporosis?
PlainTrial tracks 87 US clinical trials for Osteoporosis, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteoporosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.