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NCT05101018 · ClinicalTrials.gov registry record · Phase 4
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
A Phase 4 study of Spinal Cord Injuries and Osteoporosis, sponsored by James J. Peters Veterans Affairs Medical Center.
- Active
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
- 2
- Study locations
NCT05101018: Active Phase 4 study of Spinal Cord Injuries and Osteoporosis, sponsored by James J. Peters Veterans Affairs Medical Center.
NCT05101018 is a Phase 4 study of Spinal Cord Injuries and Osteoporosis that is active but no longer recruiting, run by James J. Peters Veterans Affairs Medical Center. The registered enrollment target is 40 participants, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (34% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05101018, a Phase 4 study of Spinal Cord Injuries and Osteoporosis, is active but no longer recruiting, sponsored by James J. Peters Veterans Affairs Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
- 2
- Study locations
Study Summary
The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of denosumab administration alone.
Primary Outcome
BMD at the distal femur metaphysis will be obtained by dual energy X-ray absorptiometry (DXA)
Conditions Studied
Interventions
- DRUG Romosozumab
- DRUG Denosumab
Study Locations (2)
New Jersey
- Kessler Institute for Rehabilitation - West Orange
New York
- James J. Peters VA Medical Center - The Bronx
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2021-11-01 |
| Est. Completion | 2027-11-01 |
| Phase | Phase 4 |
What the registry record for NCT05101018 still lists
NCT05101018 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (34% lower).
The record links to 2 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 2 interventions - of which Romosozumab is the first listed.
NCT05101018 reports a single indexed study location in New Jersey, New York.
Frequently Asked Questions
What is clinical trial NCT05101018 about?
NCT05101018 is a clinical study titled "Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI". The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of denosumab administration alone.
What is the current status of trial NCT05101018?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2021-11-01. Estimated completion is 2027-11-01.
What conditions does trial NCT05101018 study?
This clinical trial studies the following conditions: Spinal Cord Injuries, Osteoporosis.
What interventions are being tested in trial NCT05101018?
The interventions under investigation include: Romosozumab (DRUG), Denosumab (DRUG).
Who is sponsoring clinical trial NCT05101018?
This trial is sponsored by James J. Peters Veterans Affairs Medical Center, which has 39 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05101018 being conducted?
This trial has 2 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05101018's enrollment target sits among peer trials
40 72nd of 202 higher than 124 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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