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NCT06041789 · ClinicalTrials.gov registry record · Phase 2
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
A Phase 2 study of Osteoporosis, sponsored by Duke University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 45
- Enrollment target
- 1
- Study location
NCT06041789 is a Phase 2 study of Osteoporosis that is actively recruiting participants, run by Duke University. The registered enrollment target is 45 participants, below the 1,545-participant average among 84 other Osteoporosis trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06041789, a Phase 2 study of Osteoporosis, is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
People with Alzheimer's disease are at an increased risk of bone fracture. Some studies have shown that those taking donepezil have a lower rate of bone fractures, but the reasons for this are unknown. The purpose of this study is to measure the effect of donepezil treatment on bone metabolism factors including bone mineral density, bone turnover markers, and bone quality. Participants in this study will have a bone density test and have blood samples collected at the baseline study visit. Participants will then be randomly assigned to donepezil or matching memantine to be taken daily by mouth for 12 months. Blood samples will be collected at 6 and 12 months. A repeat bone density test will be performed at 12 months. Participants will also complete questionnaires at each study visit.
Conditions Studied
Interventions
- DRUG Memantine
- DRUG Donepezil
Study Locations (1)
North Carolina
- Duke Memory Disorders Clinic - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2025-02-03 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06041789
The ClinicalTrials.gov registry entry for NCT06041789 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,545-participant average among 84 other Osteoporosis trials with a reported enrollment target (97% lower). The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Osteoporosis appearing as the primary indexed condition, and to 2 interventions - of which Memantine is the first listed.
NCT06041789 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT06041789 about?
NCT06041789 is a clinical study titled "Effect of Acetylcholinesterase Inhibitors on Bone Metabolism". People with Alzheimer's disease are at an increased risk of bone fracture. Some studies have shown that those taking donepezil have a lower rate of bone fractures, but the reasons for this are unknown. The purpose of this study is to measure the effect of donepezil treatment on bone metabolism facto...
What is the current status of trial NCT06041789?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 45 participants. The study started on 2025-02-03. Estimated completion is 2026-11.
What conditions does trial NCT06041789 study?
This clinical trial studies the following conditions: Osteoporosis.
What interventions are being tested in trial NCT06041789?
The interventions under investigation include: Memantine (DRUG), Donepezil (DRUG).
Who is sponsoring clinical trial NCT06041789?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06041789 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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