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ClinicalTrials.gov 29 recruiting now official registry

Chronic Obstructive Pulmonary Disease clinical trials

Every US clinical trial registered for Chronic Obstructive Pulmonary Disease — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

87 US clinical trials · 29 currently recruiting

The research picture

Chronic Obstructive Pulmonary Disease has 87 registered US clinical trials, 29 of them open to new participants right now — about 33% of the total.

29
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
6
top sponsor: Sanofi

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 3,000 participants

Emphysema Research Registry and Biosample Repository

University of Pittsburgh

NCT00307281

RECRUITING 2,000 participants

Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study

Brigham and Women's Hospital

NCT01177618

RECRUITING Phase 3 2,000 participants

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Hoffmann-La Roche

NCT05878769

RECRUITING Phase 3 942 participants

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

Sanofi

NCT07190222

RECRUITING Phase 3 942 participants

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

Sanofi

NCT07190209

RECRUITING NA 768 participants

Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease

University of Alabama at Birmingham

NCT05119556

RECRUITING Phase 2 666 participants

A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD

Upstream Bio

NCT06981078

RECRUITING Phase 2 480 participants

A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD

Verona Pharma

NCT07016412

RECRUITING 420 participants

Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT06974981

RECRUITING Phase 1 420 participants

: Vascular Function in Health and Disease

Russell Richardson

NCT02966665

RECRUITING NA 400 participants

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Seattle Institute for Biomedical and Clinical Research

NCT06390345

RECRUITING NA 305 participants

Improving Participation in Pulmonary Rehabilitation Through Peer Support and Storytelling

Baystate Medical Center

NCT05399056

RECRUITING NA 300 participants

Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management

Icahn School of Medicine at Mount Sinai

NCT06634810

RECRUITING Phase 2 240 participants

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

University of California, San Diego

NCT05237505

RECRUITING Phase 4 218 participants

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

Sanofi

NCT07053423

RECRUITING NA 200 participants

Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

Nuvaira

NCT07051707

RECRUITING NA 136 participants

Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF

Beth Israel Deaconess Medical Center

NCT05934565

RECRUITING Phase 1 128 participants

A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

Genentech

NCT06603246

RECRUITING NA 126 participants

PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.

Observational and Pragmatic Research Institute

NCT05306743

RECRUITING Phase 2 126 participants

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

VA Office of Research and Development

NCT05937854

RECRUITING 101 participants

COPD Care Pathway Among Patients With Cancer

Wake Forest University Health Sciences

NCT05984680

RECRUITING 90 participants

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Masonic Cancer Center, University of Minnesota

NCT05025774

RECRUITING 50 participants

CareCOPD - COPD Home Monitoring Study

Cognita Labs

NCT04918095

RECRUITING Phase 2 30 participants

Biological Effects of Quercetin in COPD Phase II

Temple University

NCT06003270

RECRUITING Phase 1 30 participants

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

University of Virginia

NCT03331302

RECRUITING Phase 2 30 participants

Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD

University of Miami

NCT05607719

RECRUITING NA 20 participants

The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)

University of Nebraska

NCT06524856

RECRUITING NA 20 participants

Accelerated Pulmonary Rehabilitation in the Preoperative Period

University of Vermont

NCT06432972

RECRUITING Phase 1 8 participants

Feasibility of Semaglutide in Advanced Lung Disease

University of Pennsylvania

NCT05746039

ACTIVE NOT RECRUITING 2,981 participants

Study of COPD Subgroups and Biomarkers

University of North Carolina, Chapel Hill

NCT01969344

ACTIVE NOT RECRUITING Phase 3 700 participants

A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD

Sanofi

NCT06208306

ACTIVE NOT RECRUITING Phase 2 120 participants

Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD

Merck Sharp & Dohme

NCT05612035

ACTIVE NOT RECRUITING Phase 2 95 participants

Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics

University of Virginia

NCT03002389

ACTIVE NOT RECRUITING Phase 2 30 participants

A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD

Areteia Therapeutics

NCT06533553

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects

Milton S. Hershey Medical Center

NCT05239793

COMPLETED 98,278 participants

Replication of the INSPIRE Trial in Healthcare Claims Data

Brigham and Women's Hospital

NCT05179512

COMPLETED 12,255 participants

Observational Study of Obstructive Lung Disease (NOVELTY)

AstraZeneca

NCT02760329

COMPLETED Phase 4 3,635 participants

Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.

AstraZeneca

NCT01966107

COMPLETED 3,598 participants

Exacerbations and Real-World Outcomes Among Patients With Chronic Obstructive Pulmonary Disease Following Severe Exacerbation

AstraZeneca

NCT07414134

COMPLETED 2,085 participants

Identifying Inflammatory Biomarkers of Chronic Obstructive Pulmonary Disease

University of Arizona

NCT00394940

COMPLETED Phase 3 1,595 participants

AMPLIFY - D6571C00001 Duaklir USA Phase III Study

AstraZeneca

NCT02796677

COMPLETED Phase 3 1,200 participants

A Comparison of SYMBICORT® pMDI With Formoterol Turbuhaler® in Subjects With COPD

AstraZeneca

NCT00419744

COMPLETED Phase 3 1,100 participants

OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)

AstraZeneca

NCT00076089

COMPLETED Phase 3 939 participants

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation

Sanofi

NCT03930732

COMPLETED Phase 3 935 participants

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Sanofi

NCT04456673

COMPLETED Phase 3 763 participants

A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD

Verona Pharma

NCT04535986

COMPLETED NA 743 participants

Veterans Integrated Service Network (VISN) 23 Lung Disease Self Management/Case Management Program

US Department of Veterans Affairs

NCT00126776

COMPLETED Phase 3 741 participants

Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD

Sumitomo Pharma America

NCT00064402

COMPLETED 670 participants

Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)

Johns Hopkins University

NCT00889447

COMPLETED Phase 3 443 participants

Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease

Sumitomo Pharma America

NCT00250679

COMPLETED Phase 3 440 participants

NVA237 Versus Placebo 12-week Efficacy Study

Novartis Pharmaceuticals

NCT01709864

COMPLETED Phase 3 357 participants

Efficacy and Safety Study of QVA149 in COPD Patients

Novartis Pharmaceuticals

NCT02487446

COMPLETED 336 participants

Audio Data Collection for Identification and Classification of Coughing

HealthMode

NCT04326309

COMPLETED 330 participants

HIV-related Accelerated Aging of the Airway Epithelium

Weill Medical College of Cornell University

NCT01974219

COMPLETED Phase 2 237 participants

PT003 MDI Cardiovascular Safety Study

Pearl Therapeutics

NCT01349803

COMPLETED NA 200 participants

Anxiety and COPD Evaluation

NYU Langone Health

NCT02740465

COMPLETED NA 182 participants

Active for Life: Chronic Obstructive Pulmonary Disease

University of Michigan

NCT03201198

COMPLETED NA 172 participants

Remote Physician Care for Home Hospital Patients

Brigham and Women's Hospital

NCT04080570

COMPLETED NA 142 participants

Video vs. TTG Respiratory Inhaler Technique Assessment and InstructioN (V-TRaIN)

University of Chicago

NCT02611531

COMPLETED NA 139 participants

Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA

Peter Lindenauer, MD

NCT05562037

COMPLETED Phase 2 118 participants

Study to Evaluate the Efficacy, Safety and Pharmacokinetics of PT001, PT003, and PT005 Following Chronic Dosing (7 Days) in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)

Pearl Therapeutics

NCT01085045

COMPLETED 100 participants

Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease

University of North Carolina, Chapel Hill

NCT00903955

COMPLETED NA 97 participants

Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions

Treatment Research Institute

NCT02059005

COMPLETED NA 91 participants

Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD

New York Presbyterian Brooklyn Methodist Hospital

NCT03094806

COMPLETED 75 participants

Vibration Response Imaging in Chronic Obstructive Pulmonary Disease and Asthma

Deep Breeze

NCT00542282

COMPLETED Phase 4 70 participants

Nebulized Hypertonic Saline for Inpatient Use in COPD

OhioHealth

NCT02266875

COMPLETED Phase 3 68 participants

A Crossover Study to Determine the 24 Hour Lung Function Profile of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Novartis Pharmaceuticals

NCT00622635

COMPLETED Phase 2 64 participants

A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Mylan

NCT02109172

COMPLETED Phase 2 57 participants

Confirmatory Dose Finding Study of 2 Dosages of CHF 4226 pMDI (Carmoterol) in Patients With COPD

Chiesi Farmaceutici S.p.A.

NCT00640484

COMPLETED NA 56 participants

COPD Assessment and Management Bundle Versus Usual Care

University of Illinois at Chicago

NCT01833026

COMPLETED NA 52 participants

Indoor Air Quality and Respiratory Symptoms in Former Smokers

Intermountain Health Care

NCT02956213

COMPLETED Phase 2 46 participants

A Phase IIb Study of Glycopyrrolate Inhalation Solution Over 1 Week in Subjects With COPD

Verona Pharma

NCT06545500

COMPLETED Phase 2 33 participants

A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease

Verona Pharma

NCT07132983

COMPLETED 33 participants

Modifying Exercise for the COPD Patient

Angela N Fellner PhD CCRP

NCT02143206

COMPLETED Phase 1 26 participants

Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease

Kimera Society

NCT02216630

COMPLETED Phase 2 25 participants

A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00094562

COMPLETED Phase 2 24 participants

Inhaled Iloprost, Dynamic Hyperinflation, and Oxidative Stress in COPD Patients

Louisiana State University Health Sciences Center in New Orleans

NCT01941225

COMPLETED Phase 1 20 participants

Mindfulness Based Stress Reduction in COPD

Mayo Clinic

NCT01058499

COMPLETED NA 20 participants

Efficacy of Inhaling Bronchodilator Medications in Chronic Obstructive Pulmonary Disease

Dartmouth-Hitchcock Medical Center

NCT01391559

COMPLETED Phase 2 17 participants

Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies

University of Alabama at Birmingham

NCT03244059

COMPLETED NA 15 participants

Effects of the Breathe Technologies Ventilation System in Subjects With Chronic Obstructive Pulmonary Disease

Breathe Technologies

NCT01372462

COMPLETED Phase 1 15 participants

Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD)

Mayo Clinic

NCT04047810

COMPLETED Phase 4 14 participants

The Effect of STIOLTO™ RESPIMAT® on Fatigue in Chronic Obstructive Pulmonary Disease

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

NCT02845752

COMPLETED NA 12 participants

Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients

Texas A&M University

NCT01154400

COMPLETED Phase 1 11 participants

Safety, Tolerability, and Pharmacokinetics of Andecaliximab in Adults With Chronic Obstructive Pulmonary Disease (COPD)

Gilead Sciences

NCT02077465

COMPLETED NA 8 participants

Uphill Walking as Exercise for COPD Patients

VA Office of Research and Development

NCT04026529

COMPLETED NA 7 participants

Rural Home Hospital: Proof of Concept

Brigham and Women's Hospital

NCT04531280

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 18
Phase 3 15
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Obstructive Pulmonary Disease Trial Landscape

ClinicalTrials.gov lists 87 US studies indexed under Chronic Obstructive Pulmonary Disease, and 29 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Obstructive Pulmonary Disease shows 19 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Obstructive Pulmonary Disease is led by Sanofi with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 87 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Obstructive Pulmonary Disease?

PlainTrial tracks 87 US clinical trials for Chronic Obstructive Pulmonary Disease, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Obstructive Pulmonary Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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