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Chronic Obstructive Pulmonary Disease clinical trials
Every US clinical trial registered for Chronic Obstructive Pulmonary Disease — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
87 US clinical trials · 29 currently recruiting
The research picture
Chronic Obstructive Pulmonary Disease has 87 registered US clinical trials, 29 of them open to new participants right now — about 33% of the total.
- 29
- recruiting participants now
- 33%
- of trials open to enrollment
- 19
- in Phase 3–4 (later-stage)
- 6
- top sponsor: Sanofi
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Emphysema Research Registry and Biosample Repository
University of Pittsburgh
NCT00307281
Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
Brigham and Women's Hospital
NCT01177618
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Hoffmann-La Roche
NCT05878769
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
Sanofi
NCT07190222
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
Sanofi
NCT07190209
Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease
University of Alabama at Birmingham
NCT05119556
A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
Upstream Bio
NCT06981078
A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD
Verona Pharma
NCT07016412
Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT06974981
: Vascular Function in Health and Disease
Russell Richardson
NCT02966665
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
Seattle Institute for Biomedical and Clinical Research
NCT06390345
Improving Participation in Pulmonary Rehabilitation Through Peer Support and Storytelling
Baystate Medical Center
NCT05399056
Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management
Icahn School of Medicine at Mount Sinai
NCT06634810
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
University of California, San Diego
NCT05237505
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
Sanofi
NCT07053423
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Nuvaira
NCT07051707
Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF
Beth Israel Deaconess Medical Center
NCT05934565
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Genentech
NCT06603246
PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.
Observational and Pragmatic Research Institute
NCT05306743
Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH
VA Office of Research and Development
NCT05937854
COPD Care Pathway Among Patients With Cancer
Wake Forest University Health Sciences
NCT05984680
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
Masonic Cancer Center, University of Minnesota
NCT05025774
CareCOPD - COPD Home Monitoring Study
Cognita Labs
NCT04918095
Biological Effects of Quercetin in COPD Phase II
Temple University
NCT06003270
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
University of Virginia
NCT03331302
Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD
University of Miami
NCT05607719
The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)
University of Nebraska
NCT06524856
Accelerated Pulmonary Rehabilitation in the Preoperative Period
University of Vermont
NCT06432972
Feasibility of Semaglutide in Advanced Lung Disease
University of Pennsylvania
NCT05746039
Study of COPD Subgroups and Biomarkers
University of North Carolina, Chapel Hill
NCT01969344
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
Sanofi
NCT06208306
Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD
Merck Sharp & Dohme
NCT05612035
Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics
University of Virginia
NCT03002389
A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD
Areteia Therapeutics
NCT06533553
Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects
Milton S. Hershey Medical Center
NCT05239793
Replication of the INSPIRE Trial in Healthcare Claims Data
Brigham and Women's Hospital
NCT05179512
Observational Study of Obstructive Lung Disease (NOVELTY)
AstraZeneca
NCT02760329
Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.
AstraZeneca
NCT01966107
Exacerbations and Real-World Outcomes Among Patients With Chronic Obstructive Pulmonary Disease Following Severe Exacerbation
AstraZeneca
NCT07414134
Identifying Inflammatory Biomarkers of Chronic Obstructive Pulmonary Disease
University of Arizona
NCT00394940
AMPLIFY - D6571C00001 Duaklir USA Phase III Study
AstraZeneca
NCT02796677
A Comparison of SYMBICORT® pMDI With Formoterol Turbuhaler® in Subjects With COPD
AstraZeneca
NCT00419744
OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)
AstraZeneca
NCT00076089
Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation
Sanofi
NCT03930732
Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation
Sanofi
NCT04456673
A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
Verona Pharma
NCT04535986
Veterans Integrated Service Network (VISN) 23 Lung Disease Self Management/Case Management Program
US Department of Veterans Affairs
NCT00126776
Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD
Sumitomo Pharma America
NCT00064402
Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)
Johns Hopkins University
NCT00889447
Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease
Sumitomo Pharma America
NCT00250679
NVA237 Versus Placebo 12-week Efficacy Study
Novartis Pharmaceuticals
NCT01709864
Efficacy and Safety Study of QVA149 in COPD Patients
Novartis Pharmaceuticals
NCT02487446
Audio Data Collection for Identification and Classification of Coughing
HealthMode
NCT04326309
HIV-related Accelerated Aging of the Airway Epithelium
Weill Medical College of Cornell University
NCT01974219
PT003 MDI Cardiovascular Safety Study
Pearl Therapeutics
NCT01349803
Anxiety and COPD Evaluation
NYU Langone Health
NCT02740465
Active for Life: Chronic Obstructive Pulmonary Disease
University of Michigan
NCT03201198
Remote Physician Care for Home Hospital Patients
Brigham and Women's Hospital
NCT04080570
Video vs. TTG Respiratory Inhaler Technique Assessment and InstructioN (V-TRaIN)
University of Chicago
NCT02611531
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
Peter Lindenauer, MD
NCT05562037
Study to Evaluate the Efficacy, Safety and Pharmacokinetics of PT001, PT003, and PT005 Following Chronic Dosing (7 Days) in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
Pearl Therapeutics
NCT01085045
Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease
University of North Carolina, Chapel Hill
NCT00903955
Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions
Treatment Research Institute
NCT02059005
Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD
New York Presbyterian Brooklyn Methodist Hospital
NCT03094806
Vibration Response Imaging in Chronic Obstructive Pulmonary Disease and Asthma
Deep Breeze
NCT00542282
Nebulized Hypertonic Saline for Inpatient Use in COPD
OhioHealth
NCT02266875
A Crossover Study to Determine the 24 Hour Lung Function Profile of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
Novartis Pharmaceuticals
NCT00622635
A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
Mylan
NCT02109172
Confirmatory Dose Finding Study of 2 Dosages of CHF 4226 pMDI (Carmoterol) in Patients With COPD
Chiesi Farmaceutici S.p.A.
NCT00640484
COPD Assessment and Management Bundle Versus Usual Care
University of Illinois at Chicago
NCT01833026
Indoor Air Quality and Respiratory Symptoms in Former Smokers
Intermountain Health Care
NCT02956213
A Phase IIb Study of Glycopyrrolate Inhalation Solution Over 1 Week in Subjects With COPD
Verona Pharma
NCT06545500
A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease
Verona Pharma
NCT07132983
Modifying Exercise for the COPD Patient
Angela N Fellner PhD CCRP
NCT02143206
Safety and Efficacy of Adipose Derived Stem Cells for Chronic Obstructive Pulmonary Disease
Kimera Society
NCT02216630
A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00094562
Inhaled Iloprost, Dynamic Hyperinflation, and Oxidative Stress in COPD Patients
Louisiana State University Health Sciences Center in New Orleans
NCT01941225
Mindfulness Based Stress Reduction in COPD
Mayo Clinic
NCT01058499
Efficacy of Inhaling Bronchodilator Medications in Chronic Obstructive Pulmonary Disease
Dartmouth-Hitchcock Medical Center
NCT01391559
Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies
University of Alabama at Birmingham
NCT03244059
Effects of the Breathe Technologies Ventilation System in Subjects With Chronic Obstructive Pulmonary Disease
Breathe Technologies
NCT01372462
Mesenchymal Stem Cells in the Treatment of Subjects With Advance Chronic Obstructive Pulmonary Disease (COPD)
Mayo Clinic
NCT04047810
The Effect of STIOLTO™ RESPIMAT® on Fatigue in Chronic Obstructive Pulmonary Disease
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NCT02845752
Hydrolyzed Casein and Whey Protein Supplementation and the Addition of Leucine to Induce Protein Anabolism in Malnourished COPD Patients
Texas A&M University
NCT01154400
Safety, Tolerability, and Pharmacokinetics of Andecaliximab in Adults With Chronic Obstructive Pulmonary Disease (COPD)
Gilead Sciences
NCT02077465
Uphill Walking as Exercise for COPD Patients
VA Office of Research and Development
NCT04026529
Rural Home Hospital: Proof of Concept
Brigham and Women's Hospital
NCT04531280
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 18 |
| Phase 3 | 15 |
| Phase 4 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Chronic Obstructive Pulmonary Disease Trial Landscape
ClinicalTrials.gov lists 87 US studies indexed under Chronic Obstructive Pulmonary Disease, and 29 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Chronic Obstructive Pulmonary Disease shows 19 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Chronic Obstructive Pulmonary Disease is led by Sanofi with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 87 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Chronic Obstructive Pulmonary Disease?
PlainTrial tracks 87 US clinical trials for Chronic Obstructive Pulmonary Disease, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Chronic Obstructive Pulmonary Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.