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ClinicalTrials.gov 29 recruiting now official registry

Chronic Obstructive Pulmonary Disease clinical trials

29 of 87 indexed Chronic Obstructive Pulmonary Disease trials are currently recruiting.

87 US clinical trials · 29 currently recruiting

Chronic Obstructive Pulmonary Disease is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Sanofi, running 6 of these trials.

The research picture

Chronic Obstructive Pulmonary Disease has 87 registered US clinical trials, 29 of them open to new participants right now, about 33% of the total.

29
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
6
top sponsor: Sanofi
Phase 19Phase 218Phase 315Phase 44

Active & Recent Trials

87 total, page 1 of 2

RECRUITING 3,000 participants

Emphysema Research Registry and Biosample Repository

University of Pittsburgh

NCT00307281

RECRUITING 2,000 participants

Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study

Brigham and Women's Hospital

NCT01177618

RECRUITING Phase 3 2,000 participants

A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Hoffmann-La Roche

NCT05878769

RECRUITING Phase 3 942 participants

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype

Sanofi

NCT07190222

RECRUITING Phase 3 942 participants

Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype

Sanofi

NCT07190209

RECRUITING NA 768 participants

Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease

University of Alabama at Birmingham

NCT05119556

RECRUITING Phase 2 666 participants

A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD

Upstream Bio

NCT06981078

RECRUITING Phase 2 480 participants

A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD

Verona Pharma

NCT07016412

RECRUITING 420 participants

Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT06974981

RECRUITING Phase 1 420 participants

: Vascular Function in Health and Disease

Russell Richardson

NCT02966665

RECRUITING NA 400 participants

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Seattle Institute for Biomedical and Clinical Research

NCT06390345

RECRUITING NA 305 participants

Improving Participation in Pulmonary Rehabilitation Through Peer Support and Storytelling

Baystate Medical Center

NCT05399056

RECRUITING NA 300 participants

Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management

Icahn School of Medicine at Mount Sinai

NCT06634810

RECRUITING Phase 2 240 participants

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

University of California, San Diego

NCT05237505

RECRUITING Phase 4 218 participants

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

Sanofi

NCT07053423

RECRUITING NA 200 participants

Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD

Nuvaira

NCT07051707

RECRUITING NA 136 participants

Mindful Steps 2.0: Promoting Physical Activity in Patients With COPD and HF

Beth Israel Deaconess Medical Center

NCT05934565

RECRUITING Phase 1 128 participants

A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

Genentech

NCT06603246

RECRUITING NA 126 participants

PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.

Observational and Pragmatic Research Institute

NCT05306743

RECRUITING Phase 2 126 participants

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

VA Office of Research and Development

NCT05937854

RECRUITING 101 participants

COPD Care Pathway Among Patients With Cancer

Wake Forest University Health Sciences

NCT05984680

RECRUITING 90 participants

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Masonic Cancer Center, University of Minnesota

NCT05025774

RECRUITING 50 participants

CareCOPD - COPD Home Monitoring Study

Cognita Labs

NCT04918095

RECRUITING Phase 2 30 participants

Biological Effects of Quercetin in COPD Phase II

Temple University

NCT06003270

RECRUITING Phase 1 30 participants

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

University of Virginia

NCT03331302

RECRUITING Phase 2 30 participants

Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD

University of Miami

NCT05607719

RECRUITING NA 20 participants

The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)

University of Nebraska

NCT06524856

RECRUITING NA 20 participants

Accelerated Pulmonary Rehabilitation in the Preoperative Period

University of Vermont

NCT06432972

RECRUITING Phase 1 8 participants

Feasibility of Semaglutide in Advanced Lung Disease

University of Pennsylvania

NCT05746039

ACTIVE NOT RECRUITING 2,981 participants

Study of COPD Subgroups and Biomarkers

University of North Carolina, Chapel Hill

NCT01969344

ACTIVE NOT RECRUITING Phase 3 700 participants

A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD

Sanofi

NCT06208306

ACTIVE NOT RECRUITING Phase 2 120 participants

Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD

Merck Sharp & Dohme

NCT05612035

ACTIVE NOT RECRUITING Phase 2 95 participants

Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics

University of Virginia

NCT03002389

ACTIVE NOT RECRUITING Phase 2 30 participants

A Study to Assess the Effects of Dexpramipexole in Participants With Eosinophilic COPD

Areteia Therapeutics

NCT06533553

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects

Milton S. Hershey Medical Center

NCT05239793

COMPLETED 98,278 participants

Replication of the INSPIRE Trial in Healthcare Claims Data

Brigham and Women's Hospital

NCT05179512

COMPLETED 12,255 participants

Observational Study of Obstructive Lung Disease (NOVELTY)

AstraZeneca

NCT02760329

COMPLETED Phase 4 3,635 participants

Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.

AstraZeneca

NCT01966107

COMPLETED 3,598 participants

Exacerbations and Real-World Outcomes Among Patients With Chronic Obstructive Pulmonary Disease Following Severe Exacerbation

AstraZeneca

NCT07414134

COMPLETED 2,085 participants

Identifying Inflammatory Biomarkers of Chronic Obstructive Pulmonary Disease

University of Arizona

NCT00394940

COMPLETED Phase 3 1,595 participants

AMPLIFY - D6571C00001 Duaklir USA Phase III Study

AstraZeneca

NCT02796677

COMPLETED Phase 3 1,200 participants

A Comparison of SYMBICORT® pMDI With Formoterol Turbuhaler® in Subjects With COPD

AstraZeneca

NCT00419744

COMPLETED Phase 3 1,100 participants

OPUS Study: Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease (BY217/M2-111)

AstraZeneca

NCT00076089

COMPLETED Phase 3 939 participants

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation

Sanofi

NCT03930732

COMPLETED Phase 3 935 participants

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

Sanofi

NCT04456673

COMPLETED Phase 3 763 participants

A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD

Verona Pharma

NCT04535986

COMPLETED NA 743 participants

Veterans Integrated Service Network (VISN) 23 Lung Disease Self Management/Case Management Program

US Department of Veterans Affairs

NCT00126776

COMPLETED Phase 3 741 participants

Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD

Sumitomo Pharma America

NCT00064402

COMPLETED 670 participants

Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)

Johns Hopkins University

NCT00889447

COMPLETED Phase 3 443 participants

Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease

Sumitomo Pharma America

NCT00250679

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Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 18
Phase 3 15
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Obstructive Pulmonary Disease Trial Landscape

87 indexed Chronic Obstructive Pulmonary Disease studies · 29 recruiting (33%).

Phase mix: 19 late (III/IV) vs 27 early (I/II).

Top sponsor: Sanofi (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Obstructive Pulmonary Disease?

PlainTrial tracks 87 US clinical trials for Chronic Obstructive Pulmonary Disease, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Obstructive Pulmonary Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.