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ClinicalTrials.gov 21 recruiting now official registry

End Stage Renal Disease clinical trials

Every US clinical trial registered for End Stage Renal Disease — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

70 US clinical trials · 21 currently recruiting

The research picture

End Stage Renal Disease has 70 registered US clinical trials, 21 of them open to new participants right now — about 30% of the total.

21
recruiting participants now
30%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
4
top sponsor: Vanderbilt University

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 3,306 participants

Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

University of British Columbia

NCT03674307

RECRUITING NA 1,000 participants

Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors

Johns Hopkins University

NCT03803423

RECRUITING NA 600 participants

SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

VenoStent

NCT06001827

RECRUITING NA 304 participants

Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

Sonavex

NCT06190717

RECRUITING 300 participants

Partners Calciphylaxis Biobank

Massachusetts General Hospital

NCT03032835

RECRUITING NA 300 participants

Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula

Laminate Medical Technologies

NCT06516653

RECRUITING Phase 3 156 participants

CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease

Vanderbilt University Medical Center

NCT05422534

RECRUITING 150 participants

Drug Interaction Potential of Pro-Inflammatory Conditions

Indiana University

NCT07360938

RECRUITING 100 participants

PReSeRVE-HD: Observational Study of the Merit HeRO® Graft and Super HeRO® in Patients on Hemodialysis

Merit Medical Systems

NCT06422871

RECRUITING NA 100 participants

Shared Decision Making for Kidney Transplant Candidates to Plan for an Organ Offer Decision

Hennepin Healthcare Research Institute

NCT05879302

RECRUITING Phase 2 78 participants

Impact of Envarsus XR® on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile

Roberto Gedaly

NCT03321656

RECRUITING NA 69 participants

Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients

VA Office of Research and Development

NCT04163614

RECRUITING Phase 2 60 participants

Safety and Efficacy of Empagliflozin in Hemodialysis

NYU Langone Health

NCT05786443

RECRUITING NA 60 participants

Light Therapy in End Stage Kidney Disease

University of Pennsylvania

NCT06310161

RECRUITING NA 50 participants

Intravascular Ultrasound in Patients With End-stage Renal Disease on Dialysis

Boston Medical Center

NCT04399941

RECRUITING NA 46 participants

Solv Multi-Pass Hemodialysis System In-Center Clinical Study

Medtronic - MITG

NCT07216885

RECRUITING NA 43 participants

CAPABLE Transplant

Johns Hopkins University

NCT06326905

RECRUITING 30 participants

Tulane Abdominal Transplant Institute (TATI) of Solid Organ Transplantation of HIV-Positive Recipients From HIV-Positive Donors

Tulane University

NCT05159466

RECRUITING Phase 2 28 participants

Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD

Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

NCT04580420

RECRUITING Early Phase 1 28 participants

Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis

The University of Texas Health Science Center at San Antonio

NCT05705414

RECRUITING Phase 1 15 participants

AMSC for Reducing Anastomotic Stenosis in Primary Arteriovenous Anastomoses

Houssam Farres, M.D.

NCT04392206

ACTIVE NOT RECRUITING 2,050 participants

Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure

Beth Israel Deaconess Medical Center

NCT02194582

ACTIVE NOT RECRUITING NA 656 participants

Trial to Evaluate and Assess the Effect of Comprehensive Pre-ESKD Education on Home Dialysis Use in Veterans

VA Office of Research and Development

NCT04064086

ACTIVE NOT RECRUITING 445 participants

VIRTUUS Children's Study

Children's Hospital of Philadelphia

NCT03719339

ACTIVE NOT RECRUITING Phase 2 182 participants

Communication During Hospitalization About Resuscitation Trial

University of Vermont

NCT02984124

ACTIVE NOT RECRUITING 150 participants

Central Blood Pressure and Pulse Wave Velocity in Kidney Transplant Recipients

Children's National Research Institute

NCT04212143

ACTIVE NOT RECRUITING NA 144 participants

Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)

Medtronic - MITG

NCT05696444

ACTIVE NOT RECRUITING Phase 4 30 participants

Ferric Citrate in ESRD Pilot Project

Sreedhar Mandayam

NCT03055598

ACTIVE NOT RECRUITING Phase 4 25 participants

One-month Latent Tuberculosis Treatment for Renal Transplant Candidates

Rutgers, The State University of New Jersey

NCT05411744

COMPLETED 50,000 participants

Events Before Death

Renal Research Institute

NCT01329055

COMPLETED 2,500 participants

Inflammation and Nutritional Parameters in Hemodialysis Patients Using Reprocessed Dialyzers

Fresenius Medical Care North America

NCT00440908

COMPLETED NA 650 participants

Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge

Kaiser Permanente

NCT04351880

COMPLETED NA 599 participants

Dialysis Catheter Comparative Clinical Trial

Tyco Healthcare Group

NCT00526123

COMPLETED NA 558 participants

Explore Transplant at Home: Improving Low-Income ESRD Patients' Transplant Knowledge

The Methodist Hospital Research Institute

NCT02268682

COMPLETED NA 280 participants

Palm Tocotrienols in Chronic Hemodialysis (USA)

Wayne State University

NCT02358967

COMPLETED Phase 3 269 participants

Trial to Evaluate the Sirolimus-Eluting Collagen Implant on AV Fistula Outcomes

Vascular Therapies

NCT02513303

COMPLETED NA 190 participants

Phosphate Kinetic Modeling

Fresenius Medical Care North America

NCT01003223

COMPLETED Phase 4 172 participants

A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP

Ardelyx

NCT03988920

COMPLETED 145 participants

Protein, Nutrition and Cardiovascular Disease in Stage 5 Chronic Kidney Disease

University of Utah

NCT00566670

COMPLETED Phase 3 126 participants

Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis

University of Washington

NCT03534284

COMPLETED NA 116 participants

Social Networks and Renal Education: Promoting Transplantation

Temple University

NCT03536858

COMPLETED Phase 2 109 participants

Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis

National Center for Research Resources (NCRR)

NCT00004340

COMPLETED NA 103 participants

Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD

Medtronic Endovascular

NCT02363972

COMPLETED Phase 2 88 participants

Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis

Ardelyx

NCT01764854

COMPLETED Phase 3 75 participants

A Study to Evaluate the Safety and Efficacy of Paricalcitol Capsules in Reducing Serum Intact Parathyroid Hormone Levels in End Stage Renal Disease Subjects on Peritoneal Dialysis

Abbott

NCT00646035

COMPLETED Phase 1 70 participants

C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI

Cedars-Sinai Medical Center

NCT02134314

COMPLETED 64 participants

A Study Evaluating the Association of Inflammation With Hemodialysis Access Type

Montefiore Medical Center

NCT01011985

COMPLETED Phase 1 58 participants

Effects of Hemodialysis on the Sleep/Wake Cycle

Emory University

NCT00460863

COMPLETED NA 47 participants

Effects of Oral Cholecalciferol (Vitamin D3) on Bone Health, Neuromuscular Function, and Quality of Life in Adults With Chronic Kidney Disease

Creighton University

NCT00511225

COMPLETED Phase 1 45 participants

A Study to Evaluate the Effect of Renal Function on the Biological Activity of Telavancin

Cumberland Pharmaceuticals

NCT01238796

COMPLETED Phase 1 41 participants

Use of Immune Globulin Plus Rituximab for Desensitization in Highly HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation

Stanley Jordan, MD

NCT01178216

COMPLETED Phase 4 36 participants

Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients

Duke University

NCT03781089

COMPLETED 33 participants

A Comparison of Physical Activity Levels With and Without Feedback Via Fitbit® Flex™ in Hemodialysis Patients

Renal Research Institute

NCT02320513

COMPLETED NA 31 participants

Inflammation, Proteolysis and IL-1 Beta Receptor Inhibition in Chronic Hemodialysis Patients

Vanderbilt University

NCT00420290

COMPLETED Phase 2 26 participants

The Effects of Protein Supplementation and Resistance Exercise in Hemodialysis Patients

Vanderbilt University

NCT00179140

COMPLETED Phase 1 23 participants

Study to Investigate the Pharmacokinetic Comparability of Dosing Triferic AVNU IV by Continuous Infusion and IV Bolus.

Rockwell Medical Technologies

NCT04409132

COMPLETED 20 participants

CellCept/Iron Study: The Iron Ion-Mycophenolate Mofetil Chelation Complex Interaction in Renal Allograft Recipients

University of Michigan

NCT00227045

COMPLETED Phase 2 19 participants

The Effects of Resistance Exercise and Protein Supplementation in Hemodialysis Patients

Vanderbilt University

NCT00179218

COMPLETED NA 16 participants

Treatment Modification to Reduce Symptom Burden in Hemodialysis

The Rogosin Institute

NCT01775800

COMPLETED Phase 2 12 participants

Safety and Dose Finding Study of Xigris in Hemodialysis Patients

George Washington University

NCT01227187

COMPLETED NA 12 participants

First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings

Diality

NCT06581393

COMPLETED Phase 4 12 participants

Triferic AVNU Infusion Via Freedom Pump During Hemodialysis

Rockwell Medical Technologies

NCT04689932

COMPLETED NA 11 participants

Acid-Base Composition With Use of hemoDialysates

Fresenius Medical Care North America

NCT02334267

COMPLETED Phase 2 11 participants

The Effects of Nutrition Supplementation and Resistance Exercise During Hemodialysis

Vanderbilt University

NCT00179179

COMPLETED Phase 1 10 participants

Trial of Adoptive Immunotherapy With TRACT to Prevent Rejection in Living Donor Kidney Transplant Recipients

Northwestern University

NCT02145325

COMPLETED Early Phase 1 9 participants

A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients

Roberto Gedaly

NCT03284242

COMPLETED Phase 4 7 participants

Ertapenem Pharmacokinetics in Patients in Continuous Ambulatory Peritoneal Dialysis

Albany College of Pharmacy and Health Sciences

NCT00939952

COMPLETED Phase 2 7 participants

Pharmacokinetics and Optimal Dose of Ertapenem in Hemodialysis Patients

Corewell Health East

NCT02159859

COMPLETED Phase 1 6 participants

Plazomicin Study in ESRD Patients Receiving IHD

Cipla USA

NCT04699656

COMPLETED Phase 2 1 participants

Eculizumab to Enable Renal Transplantation in Patients With History of Catastrophic Antiphospholipid Antibody Syndrome

Johns Hopkins University

NCT01029587

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 12
Phase 3 4
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the End Stage Renal Disease Trial Landscape

ClinicalTrials.gov lists 70 US studies indexed under End Stage Renal Disease, and 21 of those are currently open to recruitment — roughly 30% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for End Stage Renal Disease shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for End Stage Renal Disease is led by Vanderbilt University with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 70 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for End Stage Renal Disease?

PlainTrial tracks 70 US clinical trials for End Stage Renal Disease, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for End Stage Renal Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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