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ClinicalTrials.gov 48 recruiting now official registry

Glioma clinical trials

48 of 88 indexed Glioma trials are currently recruiting.

88 US clinical trials · 48 currently recruiting

Glioma is the subject of 88 registered US clinical trials on ClinicalTrials.gov, 48 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 53 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 8 of these trials.

The research picture

Glioma has 88 registered US clinical trials, 48 of them open to new participants right now, about 55% of the total.

48
recruiting participants now
55%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
8
top sponsor: National Cancer Institute (NCI)
Phase 138Phase 215Phase 32Phase 41

Active & Recent Trials

88 total, page 1 of 2

RECRUITING 12,000 participants

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

M.D. Anderson Cancer Center

NCT01772771

RECRUITING Phase 3 450 participants

ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

Jazz Pharmaceuticals

NCT05580562

RECRUITING Phase 3 365 participants

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

Nuvation Bio

NCT05303519

RECRUITING Phase 1 267 participants

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Pfizer

NCT05355701

RECRUITING 250 participants

Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

Jona Hattangadi-Gluth

NCT05576103

RECRUITING Phase 1 230 participants

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

Nested Therapeutics

NCT06326411

RECRUITING Phase 2 162 participants

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Black Diamond Therapeutics

NCT07326566

RECRUITING Phase 1 146 participants

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

National Cancer Institute (NCI)

NCT06161519

RECRUITING Phase 1 140 participants

Hyperpolarized Imaging in Diagnosing Participants With Glioma

Susan Chang

NCT03739411

RECRUITING NA 135 participants

Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT00870129

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING NA 120 participants

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

Mayo Clinic

NCT07074756

RECRUITING NA 100 participants

ASCENT Intervention for Brain Tumor Patients

Massachusetts General Hospital

NCT06099743

RECRUITING NA 100 participants

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Mayo Clinic

NCT04047264

RECRUITING Early Phase 1 100 participants

Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation

University of Colorado, Denver

NCT07050836

RECRUITING 96 participants

Cognitive Changes of IDH-mutant and IDH-wildtype Glioma Patients After Chemoradiotherapy With Radiation Dose to the Resting State Networks

Washington University School of Medicine

NCT04975139

RECRUITING NA 80 participants

MRE Scan for the Assessment of Differences in Tissue Stiffness Between Radiation Necrosis and Recurrent Glioma in Patients With Previously Treated Gliomas

M.D. Anderson Cancer Center

NCT04373720

RECRUITING NA 74 participants

Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

St. Jude Children's Research Hospital

NCT04065776

RECRUITING NA 60 participants

Development of MRF for Characterization of Brain Tumors After Radiotherapy

Case Comprehensive Cancer Center

NCT06101069

RECRUITING Phase 2 57 participants

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

Memorial Sloan Kettering Cancer Center

NCT05188508

RECRUITING Phase 2 55 participants

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

Stephen Bagley, MD, MSCE

NCT05345002

RECRUITING Phase 1 55 participants

Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

Plus Therapeutics

NCT01906385

RECRUITING NA 50 participants

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

University of Rochester

NCT04543201

RECRUITING 50 participants

Glioma Developmental and HyperActive Ras Tumor (DHART) Board

Memorial Sloan Kettering Cancer Center

NCT05489783

RECRUITING NA 50 participants

NeuroPathways Intervention for Brain Tumor Patients

Massachusetts General Hospital

NCT05976490

RECRUITING Phase 1 40 participants

Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment

Plus Therapeutics

NCT05460507

RECRUITING Phase 2 37 participants

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

Northwell Health

NCT02800486

RECRUITING NA 32 participants

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

University of Maryland, Baltimore

NCT04699773

RECRUITING NA 32 participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

University of Maryland, Baltimore

NCT04181684

RECRUITING Early Phase 1 30 participants

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

Children's Hospital of Philadelphia

NCT05555550

RECRUITING Phase 1 30 participants

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

Aveta Biomics

NCT06011109

RECRUITING NA 30 participants

Non-invasive Glioma Characterization Through Molecular Imaging

University of Miami

NCT03684109

RECRUITING Early Phase 1 30 participants

18F-Fluciclovine PET-MRI in High-grade Glioma

Children's Hospital of Philadelphia

NCT05553041

RECRUITING Phase 1 28 participants

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT06344130

RECRUITING NA 28 participants

PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

Baptist Health South Florida

NCT06397560

RECRUITING Phase 1 20 participants

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

Jonsson Comprehensive Cancer Center

NCT06650163

RECRUITING Phase 1 20 participants

A Study of 177Lu-PSMA-617 in People With Gliomas

Memorial Sloan Kettering Cancer Center

NCT07223034

RECRUITING 20 participants

Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas

OHSU Knight Cancer Institute

NCT05937776

RECRUITING 20 participants

Registering Genomics and Imaging of Tumors (ReGIT)

Indiana University

NCT05386043

RECRUITING Phase 2 20 participants

A Study Utilizing Escitalopram in Glioma Patients

University of Nebraska

NCT03728673

RECRUITING Phase 2 19 participants

Methimazole in Patients With Progressive Glioblastoma

Case Comprehensive Cancer Center

NCT05607407

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 4 16 participants

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

Rigel Pharmaceuticals

NCT07486713

RECRUITING Early Phase 1 12 participants

Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG

Nader Sanai

NCT05773326

RECRUITING NA 10 participants

Tumor Treating Fields for the Treatment of Brainstem Gliomas

Emory University

NCT05310448

RECRUITING Early Phase 1 10 participants

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

Mayo Clinic

NCT07025226

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

RECRUITING Phase 1 5 participants

Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas

University of Maryland, Baltimore

NCT04772456

ACTIVE NOT RECRUITING 400 participants

[18F]FET PET for Characterization of Progressive or Recurrent Glioma From Treatment Related Changes

Telix Pharmaceuticals (Innovations) Pty Limited

NCT07238322

ACTIVE NOT RECRUITING NA 216 participants

Couples-Based Yoga Program in Improving Quality of Life in Patients With High-Grade Glioma Undergoing Radiation Therapy and Their Partners

M.D. Anderson Cancer Center

NCT02481349

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 15
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioma Trial Landscape

88 indexed Glioma studies · 48 recruiting (55%).

Phase mix: 3 late (III/IV) vs 53 early (I/II).

Top sponsor: National Cancer Institute (NCI) (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioma?

PlainTrial tracks 88 US clinical trials for Glioma, of which 48 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.