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Osteoporosis clinical trials
11 of 87 indexed Osteoporosis trials are currently recruiting.
87 US clinical trials · 11 currently recruiting
Osteoporosis is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 4 of these trials.
The research picture
Osteoporosis has 87 registered US clinical trials, 11 of them open to new participants right now, about 13% of the total.
- 11
- recruiting participants now
- 13%
- of trials open to enrollment
- 28
- in Phase 3–4 (later-stage)
- 4
- top sponsor: University of Colorado, Denver
Active & Recent Trials
87 total, page 2 of 2
Hormone Replacement Therapy to Treat Turner Syndrome
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00013546
Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index
HealthEast Care System
NCT02435147
Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)
Rutgers University
NCT01631292
Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women
Massachusetts General Hospital
NCT00086619
A Comparison Study of PF708 and Forteo in Healthy Subjects
Pfenex
NCT02656810
3-Week Parathyroid Hormone-related Protein (PTHrP) Dose Escalation Study in Post-Menopausal Women
University of Pittsburgh
NCT00222872
Prevention of Bone Loss After Acute SCI by Zoledronic Acid
Northwestern University
NCT02325414
Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer
Mayo Clinic
NCT00436917
Determinants of Bone Mineral Density and Metabolic Syndrome in South Asian Indian Men
Drexel University
NCT03600675
Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma
Duke University
NCT00301873
Abaloparatide Before Total Knee Arthroplasty
University of Wisconsin, Madison
NCT04167163
Effect of Calcium Supplement Particle Size and Vitamin D Supplement on Calcium Retention in Adolescent Girls
Purdue University
NCT01005381
Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women
University of California, San Francisco
NCT00504166
Effect of Two Exercise Programs on Bone Strength and Architecture
University of Colorado, Denver
NCT02636530
S-32 PG 242 Short Stem
St. Louis Joint Replacement Institute
NCT05083728
Early Effects of Parathyroid Hormone (PTH) on the Proximal Femur
Health Research
NCT01309399
A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women
Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ U
NCT00709540
Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women
The Cleveland Clinic
NCT00361595
Effects of a 12-week Home-based Yoga on Bone and Cardiovascular Health
University of Massachusetts, Lowell
NCT04353700
Pharmacokinetics of a Single 14C-labeled Dose of Risedronate or Alendronate Followed by Once-a-week Unlabeled Oral Dose
Warner Chilcott
NCT00577850
Validation of a Revised Food Frequency Questionnaire
University of Nebraska
NCT02693184
Secondary Prevention of Osteoporosis
Hebrew SeniorLife
NCT00421343
Bone Mineral Density and Cancer Recurrence in Patients With Early Stage Prostate Cancer
University of Medicine and Dentistry of New Jersey
NCT00176579
12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)
Northwestern University
NCT02025179
Soluble Corn Fiber and Calcium Utilization in Adolescents
Purdue University
NCT01571440
Evaluation of Outcomes of DFine StabiliT Kyphoplasty in Vertebral Compression Fractures Due to Osteoporosis
Cedars-Sinai Medical Center
NCT01839682
Skeletal Response to Simulated Night Shift
University of Colorado, Denver
NCT05074277
Does Treatment of Hypovitaminosis D Increase Calcium Absorption?
University of Wisconsin, Madison
NCT00581828
Melatonin Osteoporosis Prevention Study
Duquesne University
NCT01152580
One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study
University of Pittsburgh
NCT00580788
Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)
Thomas J. Schnitzer
NCT00826228
PTH And Calcium Responses to Exercise (PACE) in Older Adults
University of Colorado, Denver
NCT02468817
The Effect of Protein on Calcium Absorption and Gastric Acid Production
Yale University
NCT00719160
Effects of Lagenbone on Bone Mineral Density
Southern California University of Health Sciences
NCT04557553
A Study of High-Dose Vit D Versus Standard of Care Vit D Supplementation
Wake Forest University Health Sciences
NCT05016310
Study of Low Bone Mass in Premenopausal or Perimenopausal Women
National Center for Research Resources (NCRR)
NCT00005101
The Relationship Between Vitamin D, Fingernail Thickness and Bone Density
National Center for Research Resources (NCRR)
NCT00006196
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 10 |
| Phase 3 | 12 |
| Phase 4 | 16 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteoporosis Trial Landscape
87 indexed Osteoporosis studies · 11 recruiting (13%).
Phase mix: 28 late (III/IV) vs 21 early (I/II).
Top sponsor: University of Colorado, Denver (4 trials), 9 others listed. 37 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteoporosis?
PlainTrial tracks 87 US clinical trials for Osteoporosis, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteoporosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.