Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 11 recruiting now official registry

Osteoporosis clinical trials

11 of 87 indexed Osteoporosis trials are currently recruiting.

87 US clinical trials · 11 currently recruiting

Osteoporosis is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 4 of these trials.

The research picture

Osteoporosis has 87 registered US clinical trials, 11 of them open to new participants right now, about 13% of the total.

11
recruiting participants now
13%
of trials open to enrollment
28
in Phase 3–4 (later-stage)
4
top sponsor: University of Colorado, Denver
Phase 111Phase 210Phase 312Phase 416

Active & Recent Trials

87 total, page 2 of 2

COMPLETED Phase 2 92 participants

Hormone Replacement Therapy to Treat Turner Syndrome

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00013546

COMPLETED 86 participants

Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index

HealthEast Care System

NCT02435147

COMPLETED NA 81 participants

Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)

Rutgers University

NCT01631292

COMPLETED Phase 2 80 participants

Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women

Massachusetts General Hospital

NCT00086619

COMPLETED Phase 1 70 participants

A Comparison Study of PF708 and Forteo in Healthy Subjects

Pfenex

NCT02656810

COMPLETED Phase 1 61 participants

3-Week Parathyroid Hormone-related Protein (PTHrP) Dose Escalation Study in Post-Menopausal Women

University of Pittsburgh

NCT00222872

COMPLETED Phase 2 60 participants

Prevention of Bone Loss After Acute SCI by Zoledronic Acid

Northwestern University

NCT02325414

COMPLETED NA 60 participants

Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer

Mayo Clinic

NCT00436917

COMPLETED 60 participants

Determinants of Bone Mineral Density and Metabolic Syndrome in South Asian Indian Men

Drexel University

NCT03600675

COMPLETED Phase 2 60 participants

Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma

Duke University

NCT00301873

COMPLETED Phase 4 58 participants

Abaloparatide Before Total Knee Arthroplasty

University of Wisconsin, Madison

NCT04167163

COMPLETED NA 55 participants

Effect of Calcium Supplement Particle Size and Vitamin D Supplement on Calcium Retention in Adolescent Girls

Purdue University

NCT01005381

COMPLETED Phase 4 53 participants

Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women

University of California, San Francisco

NCT00504166

COMPLETED NA 48 participants

Effect of Two Exercise Programs on Bone Strength and Architecture

University of Colorado, Denver

NCT02636530

COMPLETED 45 participants

S-32 PG 242 Short Stem

St. Louis Joint Replacement Institute

NCT05083728

COMPLETED NA 40 participants

Early Effects of Parathyroid Hormone (PTH) on the Proximal Femur

Health Research

NCT01309399

COMPLETED Phase 1 40 participants

A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women

Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ U

NCT00709540

COMPLETED NA 35 participants

Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women

The Cleveland Clinic

NCT00361595

COMPLETED NA 35 participants

Effects of a 12-week Home-based Yoga on Bone and Cardiovascular Health

University of Massachusetts, Lowell

NCT04353700

COMPLETED Phase 1 32 participants

Pharmacokinetics of a Single 14C-labeled Dose of Risedronate or Alendronate Followed by Once-a-week Unlabeled Oral Dose

Warner Chilcott

NCT00577850

COMPLETED 31 participants

Validation of a Revised Food Frequency Questionnaire

University of Nebraska

NCT02693184

COMPLETED Phase 3 29 participants

Secondary Prevention of Osteoporosis

Hebrew SeniorLife

NCT00421343

COMPLETED 27 participants

Bone Mineral Density and Cancer Recurrence in Patients With Early Stage Prostate Cancer

University of Medicine and Dentistry of New Jersey

NCT00176579

COMPLETED Phase 2 25 participants

12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)

Northwestern University

NCT02025179

COMPLETED NA 24 participants

Soluble Corn Fiber and Calcium Utilization in Adolescents

Purdue University

NCT01571440

COMPLETED 23 participants

Evaluation of Outcomes of DFine StabiliT Kyphoplasty in Vertebral Compression Fractures Due to Osteoporosis

Cedars-Sinai Medical Center

NCT01839682

COMPLETED NA 20 participants

Skeletal Response to Simulated Night Shift

University of Colorado, Denver

NCT05074277

COMPLETED Phase 4 19 participants

Does Treatment of Hypovitaminosis D Increase Calcium Absorption?

University of Wisconsin, Madison

NCT00581828

COMPLETED Phase 1 19 participants

Melatonin Osteoporosis Prevention Study

Duquesne University

NCT01152580

COMPLETED Early Phase 1 14 participants

One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study

University of Pittsburgh

NCT00580788

COMPLETED Phase 4 12 participants

Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)

Thomas J. Schnitzer

NCT00826228

COMPLETED NA 12 participants

PTH And Calcium Responses to Exercise (PACE) in Older Adults

University of Colorado, Denver

NCT02468817

COMPLETED Phase 4 12 participants

The Effect of Protein on Calcium Absorption and Gastric Acid Production

Yale University

NCT00719160

COMPLETED NA 10 participants

Effects of Lagenbone on Bone Mineral Density

Southern California University of Health Sciences

NCT04557553

COMPLETED NA 7 participants

A Study of High-Dose Vit D Versus Standard of Care Vit D Supplementation

Wake Forest University Health Sciences

NCT05016310

COMPLETED

Study of Low Bone Mass in Premenopausal or Perimenopausal Women

National Center for Research Resources (NCRR)

NCT00005101

COMPLETED Phase 1

The Relationship Between Vitamin D, Fingernail Thickness and Bone Density

National Center for Research Resources (NCRR)

NCT00006196

← Previous Page 2 of 2

Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 10
Phase 3 12
Phase 4 16

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteoporosis Trial Landscape

87 indexed Osteoporosis studies · 11 recruiting (13%).

Phase mix: 28 late (III/IV) vs 21 early (I/II).

Top sponsor: University of Colorado, Denver (4 trials), 9 others listed. 37 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteoporosis?

PlainTrial tracks 87 US clinical trials for Osteoporosis, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteoporosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.