Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Osteoporosis

Open-data reference.

87 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING NA 2,634 participants

RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

University of Alabama at Birmingham

NCT06455085

RECRUITING NA 2,000 participants

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

Johns Hopkins University

NCT05845021

RECRUITING NA 1,344 participants

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

Brigham and Women's Hospital

NCT06731608

RECRUITING 648 participants

The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures

AO Foundation, AO Spine

NCT07027306

RECRUITING NA 220 participants

Synbiotic to Attenuate Resorption of the Skeleton

Hebrew SeniorLife

NCT06389539

RECRUITING Phase 4 155 participants

Preserving Geriatric Muscle With an Osteoporosis Medication

Susan L. Greenspan

NCT06118905

RECRUITING NA 120 participants

Mode of Exercise and Bone Biomarkers in Older Veterans

VA Office of Research and Development

NCT05266976

RECRUITING 100 participants

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Bettina Mittendorfer

NCT07083557

RECRUITING Phase 3 56 participants

EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy

University of Texas Southwestern Medical Center

NCT05998863

RECRUITING Phase 4 50 participants

Combined Anabolic Therapy

Massachusetts General Hospital

NCT06558188

RECRUITING Phase 2 45 participants

Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

Duke University

NCT06041789

ACTIVE NOT RECRUITING Phase 4 2,650 participants

Trial of Parkinson's And Zoledronic Acid

California Pacific Medical Center Research Institute

NCT03924414

ACTIVE NOT RECRUITING NA 190 participants

Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

Beth Israel Deaconess Medical Center

NCT03076034

ACTIVE NOT RECRUITING Phase 4 184 participants

Romosozumab Use to Build Skeletal Integrity

Susan L. Greenspan

NCT05058976

ACTIVE NOT RECRUITING NA 53 participants

Sickle Cell Disease (SCD) Bone Pain Study

University of California, Davis

NCT05283148

ACTIVE NOT RECRUITING Phase 4 51 participants

Comparative Antiresorptive Efficacy Discontinuation of Denosumab

Massachusetts General Hospital

NCT03623633

ACTIVE NOT RECRUITING Phase 4 45 participants

Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study

University of Alabama at Birmingham

NCT04177940

ACTIVE NOT RECRUITING Phase 4 40 participants

Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI

James J. Peters Veterans Affairs Medical Center

NCT05101018

ACTIVE NOT RECRUITING 40 participants

Skeletal Effects of Chronic Night Shift

University of Colorado, Denver

NCT05091021

ACTIVE NOT RECRUITING Phase 4 20 participants

Muscle Impact of Treating Osteoporosis

Nami Safai Haeri

NCT05666310

ACTIVE NOT RECRUITING Phase 1 10 participants

A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis

Memorial Sloan Kettering Cancer Center

NCT05775094

COMPLETED 57,073 participants

Evaluation of VLER-Indiana Health Information Exchange Demonstration Project

VA Office of Research and Development

NCT01446705

COMPLETED Phase 1 30,000 participants

Patient- and Physician-Based Osteoporosis Education

Brigham and Women's Hospital

NCT00073190

COMPLETED Phase 3 7,700 participants

HORIZON-PFT: Pivotal Fracture Trial

Novartis Pharmaceuticals

NCT00049829

COMPLETED Phase 4 4,659 participants

Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids

University of Alabama at Birmingham

NCT01378689

COMPLETED NA 3,000 participants

Improving Quality With Outpatient Decision Support

Agency for Healthcare Research and Quality (AHRQ)

NCT00225628

COMPLETED Phase 3 2,456 participants

Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)

Novartis

NCT00145327

COMPLETED 2,452 participants

Ultrarunners Longitudinal TRAcking Study (ULTRA)

Stanford University

NCT02014038

COMPLETED Phase 3 1,683 participants

Open Label Extension Study of PREOS

Shire

NCT00172133

COMPLETED Phase 3 1,200 participants

Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy

GTx

NCT00129142

COMPLETED Phase 3 1,083 participants

Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women

Pfizer

NCT00242710

COMPLETED NA 741 participants

Yoga in the Treatment of Osteoporosis

Manhattan Physical Medicine and Rehabilitation

NCT02399176

COMPLETED 560 participants

Age Dependend Diagnostic Thresholds for Osteoporosis Bindex Ultrasonometer

Bone Index Finland

NCT01978834

COMPLETED NA 560 participants

CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD

Punam K Saha

NCT03534934

COMPLETED Phase 3 452 participants

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

National Institute on Aging (NIA)

NCT00183001

COMPLETED 450 participants

A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00069004

COMPLETED Phase 3 450 participants

Effect of Calcium and Vitamin D on Bone Loss From the Hip

Tufts University

NCT00357643

COMPLETED Phase 3 439 participants

Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer

Alliance for Clinical Trials in Oncology

NCT00022087

COMPLETED Phase 3 428 participants

Comparison of Teriparatide With Alendronate for Treating Glucocorticoid-Induced Osteoporosis

Eli Lilly and Company

NCT00051558

COMPLETED Phase 2 354 participants

Calcium and Bone Mass in Young Females

Ohio State University

NCT00000402

COMPLETED NA 354 participants

Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs

Medtronic Spinal and Biologics

NCT01871519

COMPLETED Phase 2 340 participants

Osteoporosis Prevention in Preadolescent Girls

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00000413

COMPLETED NA 273 participants

GIOP Prevention Among People With Rheumatoid Arthritis

University of North Carolina, Chapel Hill

NCT00609830

COMPLETED Phase 2 241 participants

Adding Phosphorus to Osteoporosis Drug Treatment

Creighton University

NCT00074711

COMPLETED Phase 1 228 participants

Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00067600

COMPLETED Phase 3 181 participants

A Comparison of PF708 and Forteo in Osteoporosis Patients

Pfenex

NCT03002428

COMPLETED Phase 4 110 participants

Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density

Novartis

NCT00431444

COMPLETED Phase 2 105 participants

Comparison Study of PTHrP and PTH to Treat Osteoporosis

University of Pittsburgh

NCT00853723

COMPLETED Phase 4 99 participants

Effects of DHEA/Exercise on Bone, Muscle and Balance

National Aeronautics and Space Administration (NASA)

NCT00664053

COMPLETED Phase 1 96 participants

Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects

Warner Chilcott

NCT00699777

COMPLETED Phase 2 92 participants

Hormone Replacement Therapy to Treat Turner Syndrome

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00013546

COMPLETED 86 participants

Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index

HealthEast Care System

NCT02435147

COMPLETED NA 81 participants

Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)

Rutgers University

NCT01631292

COMPLETED Phase 2 80 participants

Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women

Massachusetts General Hospital

NCT00086619

COMPLETED Phase 1 70 participants

A Comparison Study of PF708 and Forteo in Healthy Subjects

Pfenex

NCT02656810

COMPLETED Phase 1 61 participants

3-Week Parathyroid Hormone-related Protein (PTHrP) Dose Escalation Study in Post-Menopausal Women

University of Pittsburgh

NCT00222872

COMPLETED Phase 2 60 participants

Prevention of Bone Loss After Acute SCI by Zoledronic Acid

Northwestern University

NCT02325414

COMPLETED NA 60 participants

Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer

Mayo Clinic

NCT00436917

COMPLETED 60 participants

Determinants of Bone Mineral Density and Metabolic Syndrome in South Asian Indian Men

Drexel University

NCT03600675

COMPLETED Phase 2 60 participants

Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma

Duke University

NCT00301873

COMPLETED Phase 4 58 participants

Abaloparatide Before Total Knee Arthroplasty

University of Wisconsin, Madison

NCT04167163

COMPLETED NA 55 participants

Effect of Calcium Supplement Particle Size and Vitamin D Supplement on Calcium Retention in Adolescent Girls

Purdue University

NCT01005381

COMPLETED Phase 4 53 participants

Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women

University of California, San Francis

NCT00504166

COMPLETED NA 48 participants

Effect of Two Exercise Programs on Bone Strength and Architecture

University of Colorado, Denver

NCT02636530

COMPLETED 45 participants

S-32 PG 242 Short Stem

St. Louis Joint Replacement Institute

NCT05083728

COMPLETED NA 40 participants

Early Effects of Parathyroid Hormone (PTH) on the Proximal Femur

Health Research

NCT01309399

COMPLETED Phase 1 40 participants

A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women

Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ U

NCT00709540

COMPLETED NA 35 participants

Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women

The Cleveland Clinic

NCT00361595

COMPLETED NA 35 participants

Effects of a 12-week Home-based Yoga on Bone and Cardiovascular Health

University of Massachusetts, Lowell

NCT04353700

COMPLETED Phase 1 32 participants

Pharmacokinetics of a Single 14C-labeled Dose of Risedronate or Alendronate Followed by Once-a-week Unlabeled Oral Dose

Warner Chilcott

NCT00577850

COMPLETED 31 participants

Validation of a Revised Food Frequency Questionnaire

University of Nebraska

NCT02693184

COMPLETED Phase 3 29 participants

Secondary Prevention of Osteoporosis

Hebrew SeniorLife

NCT00421343

COMPLETED 27 participants

Bone Mineral Density and Cancer Recurrence in Patients With Early Stage Prostate Cancer

University of Medicine and Dentistry of New Jersey

NCT00176579

COMPLETED Phase 2 25 participants

12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)

Northwestern University

NCT02025179

COMPLETED NA 24 participants

Soluble Corn Fiber and Calcium Utilization in Adolescents

Purdue University

NCT01571440

COMPLETED 23 participants

Evaluation of Outcomes of DFine StabiliT Kyphoplasty in Vertebral Compression Fractures Due to Osteoporosis

Cedars-Sinai Medical Center

NCT01839682

COMPLETED NA 20 participants

Skeletal Response to Simulated Night Shift

University of Colorado, Denver

NCT05074277

COMPLETED Phase 4 19 participants

Does Treatment of Hypovitaminosis D Increase Calcium Absorption?

University of Wisconsin, Madison

NCT00581828

COMPLETED Phase 1 19 participants

Melatonin Osteoporosis Prevention Study

Duquesne University

NCT01152580

COMPLETED Early Phase 1 14 participants

One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study

University of Pittsburgh

NCT00580788

COMPLETED Phase 4 12 participants

Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)

Thomas J. Schnitzer

NCT00826228

COMPLETED NA 12 participants

PTH And Calcium Responses to Exercise (PACE) in Older Adults

University of Colorado, Denver

NCT02468817

COMPLETED Phase 4 12 participants

The Effect of Protein on Calcium Absorption and Gastric Acid Production

Yale University

NCT00719160

COMPLETED NA 10 participants

Effects of Lagenbone on Bone Mineral Density

Southern California University of Health Sciences

NCT04557553

COMPLETED NA 7 participants

A Study of High-Dose Vit D Versus Standard of Care Vit D Supplementation

Wake Forest University Health Sciences

NCT05016310

COMPLETED

Study of Low Bone Mass in Premenopausal or Perimenopausal Women

National Center for Research Resources (NCRR)

NCT00005101

COMPLETED Phase 1

The Relationship Between Vitamin D, Fingernail Thickness and Bone Density

National Center for Research Resources (NCRR)

NCT00006196

Phase Distribution

PhaseTrial count
Early Phase 1 11
Phase 2 10
Phase 3 12
Phase 4 16

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteoporosis Trial Landscape

ClinicalTrials.gov lists 87 US studies indexed under Osteoporosis, and 11 of those are currently open to recruitment — roughly 13% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Osteoporosis shows 28 late-stage studies (Phase 3 and Phase 4 combined) alongside 21 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Osteoporosis is led by University of Colorado, Denver with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 87 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteoporosis?

PlainTrial tracks 87 US clinical trials for Osteoporosis, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteoporosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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