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Osteoporosis
Open-data reference.
87 US clinical trials · 11 currently recruiting
Active & Recent Trials
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
University of Alabama at Birmingham
NCT06455085
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
Johns Hopkins University
NCT05845021
OsteoPorotic fracTure preventION System (OPTIONS) Research Study
Brigham and Women's Hospital
NCT06731608
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
AO Foundation, AO Spine
NCT07027306
Synbiotic to Attenuate Resorption of the Skeleton
Hebrew SeniorLife
NCT06389539
Preserving Geriatric Muscle With an Osteoporosis Medication
Susan L. Greenspan
NCT06118905
Mode of Exercise and Bone Biomarkers in Older Veterans
VA Office of Research and Development
NCT05266976
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Bettina Mittendorfer
NCT07083557
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
University of Texas Southwestern Medical Center
NCT05998863
Combined Anabolic Therapy
Massachusetts General Hospital
NCT06558188
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
Duke University
NCT06041789
Trial of Parkinson's And Zoledronic Acid
California Pacific Medical Center Research Institute
NCT03924414
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
Beth Israel Deaconess Medical Center
NCT03076034
Romosozumab Use to Build Skeletal Integrity
Susan L. Greenspan
NCT05058976
Sickle Cell Disease (SCD) Bone Pain Study
University of California, Davis
NCT05283148
Comparative Antiresorptive Efficacy Discontinuation of Denosumab
Massachusetts General Hospital
NCT03623633
Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study
University of Alabama at Birmingham
NCT04177940
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
James J. Peters Veterans Affairs Medical Center
NCT05101018
Skeletal Effects of Chronic Night Shift
University of Colorado, Denver
NCT05091021
Muscle Impact of Treating Osteoporosis
Nami Safai Haeri
NCT05666310
A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis
Memorial Sloan Kettering Cancer Center
NCT05775094
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
VA Office of Research and Development
NCT01446705
Patient- and Physician-Based Osteoporosis Education
Brigham and Women's Hospital
NCT00073190
HORIZON-PFT: Pivotal Fracture Trial
Novartis Pharmaceuticals
NCT00049829
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
University of Alabama at Birmingham
NCT01378689
Improving Quality With Outpatient Decision Support
Agency for Healthcare Research and Quality (AHRQ)
NCT00225628
Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)
Novartis
NCT00145327
Ultrarunners Longitudinal TRAcking Study (ULTRA)
Stanford University
NCT02014038
Open Label Extension Study of PREOS
Shire
NCT00172133
Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy
GTx
NCT00129142
Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women
Pfizer
NCT00242710
Yoga in the Treatment of Osteoporosis
Manhattan Physical Medicine and Rehabilitation
NCT02399176
Age Dependend Diagnostic Thresholds for Osteoporosis Bindex Ultrasonometer
Bone Index Finland
NCT01978834
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
Punam K Saha
NCT03534934
Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification
National Institute on Aging (NIA)
NCT00183001
A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00069004
Effect of Calcium and Vitamin D on Bone Loss From the Hip
Tufts University
NCT00357643
Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer
Alliance for Clinical Trials in Oncology
NCT00022087
Comparison of Teriparatide With Alendronate for Treating Glucocorticoid-Induced Osteoporosis
Eli Lilly and Company
NCT00051558
Calcium and Bone Mass in Young Females
Ohio State University
NCT00000402
Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs
Medtronic Spinal and Biologics
NCT01871519
Osteoporosis Prevention in Preadolescent Girls
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00000413
GIOP Prevention Among People With Rheumatoid Arthritis
University of North Carolina, Chapel Hill
NCT00609830
Adding Phosphorus to Osteoporosis Drug Treatment
Creighton University
NCT00074711
Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00067600
A Comparison of PF708 and Forteo in Osteoporosis Patients
Pfenex
NCT03002428
Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density
Novartis
NCT00431444
Comparison Study of PTHrP and PTH to Treat Osteoporosis
University of Pittsburgh
NCT00853723
Effects of DHEA/Exercise on Bone, Muscle and Balance
National Aeronautics and Space Administration (NASA)
NCT00664053
Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects
Warner Chilcott
NCT00699777
Hormone Replacement Therapy to Treat Turner Syndrome
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00013546
Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index
HealthEast Care System
NCT02435147
Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)
Rutgers University
NCT01631292
Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women
Massachusetts General Hospital
NCT00086619
A Comparison Study of PF708 and Forteo in Healthy Subjects
Pfenex
NCT02656810
3-Week Parathyroid Hormone-related Protein (PTHrP) Dose Escalation Study in Post-Menopausal Women
University of Pittsburgh
NCT00222872
Prevention of Bone Loss After Acute SCI by Zoledronic Acid
Northwestern University
NCT02325414
Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer
Mayo Clinic
NCT00436917
Determinants of Bone Mineral Density and Metabolic Syndrome in South Asian Indian Men
Drexel University
NCT03600675
Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma
Duke University
NCT00301873
Abaloparatide Before Total Knee Arthroplasty
University of Wisconsin, Madison
NCT04167163
Effect of Calcium Supplement Particle Size and Vitamin D Supplement on Calcium Retention in Adolescent Girls
Purdue University
NCT01005381
Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women
University of California, San Francis
NCT00504166
Effect of Two Exercise Programs on Bone Strength and Architecture
University of Colorado, Denver
NCT02636530
S-32 PG 242 Short Stem
St. Louis Joint Replacement Institute
NCT05083728
Early Effects of Parathyroid Hormone (PTH) on the Proximal Femur
Health Research
NCT01309399
A Safety, Tolerability and Pharmacodynamics Study of ACE-011 (ActRIIA-IgG1) in Healthy Postmenopausal Women
Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ U
NCT00709540
Intervenous (IV) Zoledronic Acid After Forteo in Postmenopausal Women
The Cleveland Clinic
NCT00361595
Effects of a 12-week Home-based Yoga on Bone and Cardiovascular Health
University of Massachusetts, Lowell
NCT04353700
Pharmacokinetics of a Single 14C-labeled Dose of Risedronate or Alendronate Followed by Once-a-week Unlabeled Oral Dose
Warner Chilcott
NCT00577850
Validation of a Revised Food Frequency Questionnaire
University of Nebraska
NCT02693184
Secondary Prevention of Osteoporosis
Hebrew SeniorLife
NCT00421343
Bone Mineral Density and Cancer Recurrence in Patients With Early Stage Prostate Cancer
University of Medicine and Dentistry of New Jersey
NCT00176579
12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)
Northwestern University
NCT02025179
Soluble Corn Fiber and Calcium Utilization in Adolescents
Purdue University
NCT01571440
Evaluation of Outcomes of DFine StabiliT Kyphoplasty in Vertebral Compression Fractures Due to Osteoporosis
Cedars-Sinai Medical Center
NCT01839682
Skeletal Response to Simulated Night Shift
University of Colorado, Denver
NCT05074277
Does Treatment of Hypovitaminosis D Increase Calcium Absorption?
University of Wisconsin, Madison
NCT00581828
Melatonin Osteoporosis Prevention Study
Duquesne University
NCT01152580
One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study
University of Pittsburgh
NCT00580788
Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)
Thomas J. Schnitzer
NCT00826228
PTH And Calcium Responses to Exercise (PACE) in Older Adults
University of Colorado, Denver
NCT02468817
The Effect of Protein on Calcium Absorption and Gastric Acid Production
Yale University
NCT00719160
Effects of Lagenbone on Bone Mineral Density
Southern California University of Health Sciences
NCT04557553
A Study of High-Dose Vit D Versus Standard of Care Vit D Supplementation
Wake Forest University Health Sciences
NCT05016310
Study of Low Bone Mass in Premenopausal or Perimenopausal Women
National Center for Research Resources (NCRR)
NCT00005101
The Relationship Between Vitamin D, Fingernail Thickness and Bone Density
National Center for Research Resources (NCRR)
NCT00006196
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 11 |
| Phase 2 | 10 |
| Phase 3 | 12 |
| Phase 4 | 16 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteoporosis Trial Landscape
ClinicalTrials.gov lists 87 US studies indexed under Osteoporosis, and 11 of those are currently open to recruitment — roughly 13% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Osteoporosis shows 28 late-stage studies (Phase 3 and Phase 4 combined) alongside 21 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Osteoporosis is led by University of Colorado, Denver with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 87 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteoporosis?
PlainTrial tracks 87 US clinical trials for Osteoporosis, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteoporosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.