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ClinicalTrials.gov 11 recruiting now official registry

Osteoporosis clinical trials

11 of 87 indexed Osteoporosis trials are currently recruiting.

87 US clinical trials · 11 currently recruiting

Osteoporosis is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 4 of these trials.

The research picture

Osteoporosis has 87 registered US clinical trials, 11 of them open to new participants right now, about 13% of the total.

11
recruiting participants now
13%
of trials open to enrollment
28
in Phase 3–4 (later-stage)
4
top sponsor: University of Colorado, Denver
Phase 111Phase 210Phase 312Phase 416

Active & Recent Trials

87 total, page 1 of 2

RECRUITING NA 2,634 participants

RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

University of Alabama at Birmingham

NCT06455085

RECRUITING NA 2,000 participants

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

Johns Hopkins University

NCT05845021

RECRUITING NA 1,344 participants

OsteoPorotic fracTure preventION System (OPTIONS) Research Study

Brigham and Women's Hospital

NCT06731608

RECRUITING 648 participants

The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures

AO Foundation, AO Spine

NCT07027306

RECRUITING NA 220 participants

Synbiotic to Attenuate Resorption of the Skeleton

Hebrew SeniorLife

NCT06389539

RECRUITING Phase 4 155 participants

Preserving Geriatric Muscle With an Osteoporosis Medication

Susan L. Greenspan

NCT06118905

RECRUITING NA 120 participants

Mode of Exercise and Bone Biomarkers in Older Veterans

VA Office of Research and Development

NCT05266976

RECRUITING 100 participants

Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Bettina Mittendorfer

NCT07083557

RECRUITING Phase 3 56 participants

EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy

University of Texas Southwestern Medical Center

NCT05998863

RECRUITING Phase 4 50 participants

Combined Anabolic Therapy

Massachusetts General Hospital

NCT06558188

RECRUITING Phase 2 45 participants

Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

Duke University

NCT06041789

ACTIVE NOT RECRUITING Phase 4 2,650 participants

Trial of Parkinson's And Zoledronic Acid

California Pacific Medical Center Research Institute

NCT03924414

ACTIVE NOT RECRUITING NA 190 participants

Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

Beth Israel Deaconess Medical Center

NCT03076034

ACTIVE NOT RECRUITING Phase 4 184 participants

Romosozumab Use to Build Skeletal Integrity

Susan L. Greenspan

NCT05058976

ACTIVE NOT RECRUITING NA 53 participants

Sickle Cell Disease (SCD) Bone Pain Study

University of California, Davis

NCT05283148

ACTIVE NOT RECRUITING Phase 4 51 participants

Comparative Antiresorptive Efficacy Discontinuation of Denosumab

Massachusetts General Hospital

NCT03623633

ACTIVE NOT RECRUITING Phase 4 45 participants

Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study

University of Alabama at Birmingham

NCT04177940

ACTIVE NOT RECRUITING Phase 4 40 participants

Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI

James J. Peters Veterans Affairs Medical Center

NCT05101018

ACTIVE NOT RECRUITING 40 participants

Skeletal Effects of Chronic Night Shift

University of Colorado, Denver

NCT05091021

ACTIVE NOT RECRUITING Phase 4 20 participants

Muscle Impact of Treating Osteoporosis

Nami Safai Haeri

NCT05666310

ACTIVE NOT RECRUITING Phase 1 10 participants

A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis

Memorial Sloan Kettering Cancer Center

NCT05775094

COMPLETED 57,073 participants

Evaluation of VLER-Indiana Health Information Exchange Demonstration Project

VA Office of Research and Development

NCT01446705

COMPLETED Phase 1 30,000 participants

Patient- and Physician-Based Osteoporosis Education

Brigham and Women's Hospital

NCT00073190

COMPLETED Phase 3 7,700 participants

HORIZON-PFT: Pivotal Fracture Trial

Novartis Pharmaceuticals

NCT00049829

COMPLETED Phase 4 4,659 participants

Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids

University of Alabama at Birmingham

NCT01378689

COMPLETED NA 3,000 participants

Improving Quality With Outpatient Decision Support

Agency for Healthcare Research and Quality (AHRQ)

NCT00225628

COMPLETED Phase 3 2,456 participants

Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)

Novartis

NCT00145327

COMPLETED 2,452 participants

Ultrarunners Longitudinal TRAcking Study (ULTRA)

Stanford University

NCT02014038

COMPLETED Phase 3 1,683 participants

Open Label Extension Study of PREOS

Shire

NCT00172133

COMPLETED Phase 3 1,200 participants

Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy

GTx

NCT00129142

COMPLETED Phase 3 1,083 participants

Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women

Pfizer

NCT00242710

COMPLETED NA 741 participants

Yoga in the Treatment of Osteoporosis

Manhattan Physical Medicine and Rehabilitation

NCT02399176

COMPLETED 560 participants

Age Dependend Diagnostic Thresholds for Osteoporosis Bindex Ultrasonometer

Bone Index Finland

NCT01978834

COMPLETED NA 560 participants

CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD

Punam K Saha

NCT03534934

COMPLETED Phase 3 452 participants

Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification

National Institute on Aging (NIA)

NCT00183001

COMPLETED 450 participants

A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00069004

COMPLETED Phase 3 450 participants

Effect of Calcium and Vitamin D on Bone Loss From the Hip

Tufts University

NCT00357643

COMPLETED Phase 3 439 participants

Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer

Alliance for Clinical Trials in Oncology

NCT00022087

COMPLETED Phase 3 428 participants

Comparison of Teriparatide With Alendronate for Treating Glucocorticoid-Induced Osteoporosis

Eli Lilly and Company

NCT00051558

COMPLETED Phase 2 354 participants

Calcium and Bone Mass in Young Females

Ohio State University

NCT00000402

COMPLETED NA 354 participants

Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs

Medtronic Spinal and Biologics

NCT01871519

COMPLETED Phase 2 340 participants

Osteoporosis Prevention in Preadolescent Girls

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00000413

COMPLETED NA 273 participants

GIOP Prevention Among People With Rheumatoid Arthritis

University of North Carolina, Chapel Hill

NCT00609830

COMPLETED Phase 2 241 participants

Adding Phosphorus to Osteoporosis Drug Treatment

Creighton University

NCT00074711

COMPLETED Phase 1 228 participants

Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00067600

COMPLETED Phase 3 181 participants

A Comparison of PF708 and Forteo in Osteoporosis Patients

Pfenex

NCT03002428

COMPLETED Phase 4 110 participants

Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density

Novartis

NCT00431444

COMPLETED Phase 2 105 participants

Comparison Study of PTHrP and PTH to Treat Osteoporosis

University of Pittsburgh

NCT00853723

COMPLETED Phase 4 99 participants

Effects of DHEA/Exercise on Bone, Muscle and Balance

National Aeronautics and Space Administration (NASA)

NCT00664053

COMPLETED Phase 1 96 participants

Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects

Warner Chilcott

NCT00699777

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 10
Phase 3 12
Phase 4 16

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteoporosis Trial Landscape

87 indexed Osteoporosis studies · 11 recruiting (13%).

Phase mix: 28 late (III/IV) vs 21 early (I/II).

Top sponsor: University of Colorado, Denver (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteoporosis?

PlainTrial tracks 87 US clinical trials for Osteoporosis, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteoporosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.