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Osteoporosis: full-pipeline trial registry
11 of 87 indexed Osteoporosis trials are currently recruiting.
Corpus placement: #158 of 28,707 conditions by registered trial count.
87 US clinical trials · 11 currently recruiting · #158 of 28,707 conditions by registered trial count
Osteoporosis: 87 US clinical trials tracked, 11 recruiting.
Osteoporosis is the subject of 87 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 28 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 4 of these trials.
Enrollment posture brief
Registry condition osteoporosis
OPEN 11 | RECR 13% | LATE 28 | EARLY 21 | RANK #158 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Acute Respiratory Infection (13% recruiting · 8 trials)
Osteoporosis lists 11 open slots (13% of 87 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoporosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoporosis is recruiting below its size-band peers.
11 of 87 indexed trials (12.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoporosis trials is spread across many organizations.
University of Colorado, Denver accounts for 4 of 87 trials (4.6%). 65 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoporosis enrolment sits around 81 participants.
Median target enrolment is 81 among the 85 trials that report a genuine target (sentinel values excluded). 47 of those (55.3%) plan for fewer than 100 participants.
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Osteoporosis research is mostly interventional.
73 interventional and 14 observational studies make up this index (83.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
87 total, page 1 of 2
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
University of Alabama at Birmingham
NCT06455085
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
Johns Hopkins University
NCT05845021
OsteoPorotic fracTure preventION System (OPTIONS) Research Study
Brigham and Women's Hospital
NCT06731608
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
AO Foundation, AO Spine
NCT07027306
Synbiotic to Attenuate Resorption of the Skeleton
Hebrew SeniorLife
NCT06389539
Preserving Geriatric Muscle With an Osteoporosis Medication
Susan L. Greenspan
NCT06118905
Mode of Exercise and Bone Biomarkers in Older Veterans
VA Office of Research and Development
NCT05266976
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Bettina Mittendorfer
NCT07083557
EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy
University of Texas Southwestern Medical Center
NCT05998863
Combined Anabolic Therapy
Massachusetts General Hospital
NCT06558188
Effect of Acetylcholinesterase Inhibitors on Bone Metabolism
Duke University
NCT06041789
Trial of Parkinson's And Zoledronic Acid
California Pacific Medical Center Research Institute
NCT03924414
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
Beth Israel Deaconess Medical Center
NCT03076034
Romosozumab Use to Build Skeletal Integrity
Susan L. Greenspan
NCT05058976
Sickle Cell Disease (SCD) Bone Pain Study
University of California, Davis
NCT05283148
Comparative Antiresorptive Efficacy Discontinuation of Denosumab
Massachusetts General Hospital
NCT03623633
Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study
University of Alabama at Birmingham
NCT04177940
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
James J. Peters Veterans Affairs Medical Center
NCT05101018
Skeletal Effects of Chronic Night Shift
University of Colorado, Denver
NCT05091021
Muscle Impact of Treating Osteoporosis
Nami Safai Haeri
NCT05666310
A Study of Romosozumab in Women With Multiple Myeloma and Osteoporosis
Memorial Sloan Kettering Cancer Center
NCT05775094
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
VA Office of Research and Development
NCT01446705
Patient- and Physician-Based Osteoporosis Education
Brigham and Women's Hospital
NCT00073190
HORIZON-PFT: Pivotal Fracture Trial
Novartis Pharmaceuticals
NCT00049829
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
University of Alabama at Birmingham
NCT01378689
Improving Quality With Outpatient Decision Support
Agency for Healthcare Research and Quality (AHRQ)
NCT00225628
Double-blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis)
Novartis
NCT00145327
Ultrarunners Longitudinal TRAcking Study (ULTRA)
Stanford University
NCT02014038
Open Label Extension Study of PREOS
Shire
NCT00172133
Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy
GTx
NCT00129142
Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women
Pfizer
NCT00242710
Yoga in the Treatment of Osteoporosis
Manhattan Physical Medicine and Rehabilitation
NCT02399176
Age Dependend Diagnostic Thresholds for Osteoporosis Bindex Ultrasonometer
Bone Index Finland
NCT01978834
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
Punam K Saha
NCT03534934
Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification
National Institute on Aging (NIA)
NCT00183001
A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and Youth
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00069004
Effect of Calcium and Vitamin D on Bone Loss From the Hip
Tufts University
NCT00357643
Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer
Alliance for Clinical Trials in Oncology
NCT00022087
Comparison of Teriparatide With Alendronate for Treating Glucocorticoid-Induced Osteoporosis
Eli Lilly and Company
NCT00051558
Calcium and Bone Mass in Young Females
Ohio State University
NCT00000402
Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs
Medtronic Spinal and Biologics
NCT01871519
Osteoporosis Prevention in Preadolescent Girls
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00000413
GIOP Prevention Among People With Rheumatoid Arthritis
University of North Carolina, Chapel Hill
NCT00609830
Adding Phosphorus to Osteoporosis Drug Treatment
Creighton University
NCT00074711
Improving Bone Health in Adolescent Girls: The Youth Osteoporosis and Understanding Total Health (YOUTH) Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00067600
A Comparison of PF708 and Forteo in Osteoporosis Patients
Pfenex
NCT03002428
Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density
Novartis
NCT00431444
Comparison Study of PTHrP and PTH to Treat Osteoporosis
University of Pittsburgh
NCT00853723
Effects of DHEA/Exercise on Bone, Muscle and Balance
National Aeronautics and Space Administration (NASA)
NCT00664053
Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects
Warner Chilcott
NCT00699777
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 10 |
| Phase 3 | 12 |
| Phase 4 | 16 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoporosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoporosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoporosis page
87 registered trials, 11 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 11 Osteoporosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Colorado, Denver sponsors the most Osteoporosis trials on record, review their full trial history before evaluating a specific study. See University of Colorado, Denver's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoporosis condition card totals 87 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.