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ClinicalTrials.gov 37 recruiting now official registry

Metastatic Solid Tumor clinical trials

37 of 53 indexed Metastatic Solid Tumor trials are currently recruiting.

53 US clinical trials · 37 currently recruiting

Metastatic Solid Tumor is the subject of 53 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 4 of these trials.

The research picture

Metastatic Solid Tumor has 53 registered US clinical trials, 37 of them open to new participants right now, about 70% of the total.

37
recruiting participants now
70%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Eli Lilly and Company
Phase 147Phase 23

Active & Recent Trials

53 total, page 1 of 2

RECRUITING Phase 1 840 participants

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

Nuvalent

NCT05384626

RECRUITING Phase 1 540 participants

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT05875168

RECRUITING Phase 1 499 participants

Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies

TopAlliance Biosciences

NCT04137900

RECRUITING Phase 1 490 participants

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

Eli Lilly and Company

NCT06238479

RECRUITING Phase 1 420 participants

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Eli Lilly and Company

NCT06465069

RECRUITING Phase 1 403 participants

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Frontier Medicines Corporation

NCT06244771

RECRUITING Phase 1 359 participants

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

Nuvalent

NCT05118789

RECRUITING Phase 1 358 participants

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

GI Innovation

NCT05824975

RECRUITING Phase 1 340 participants

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

Eli Lilly and Company

NCT06561685

RECRUITING Phase 1 317 participants

GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors

GI Innovation

NCT04977453

RECRUITING Phase 1 300 participants

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

PMV Pharmaceuticals

NCT04585750

RECRUITING Phase 1 220 participants

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06545942

RECRUITING Phase 1 220 participants

Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

Circle Pharma

NCT06577987

RECRUITING Phase 1 200 participants

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

Nuvalent

NCT06521554

RECRUITING Phase 1 177 participants

JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors

Jazz Pharmaceuticals

NCT06108050

RECRUITING Phase 1 175 participants

Study of LP-184 in Patients With Advanced Solid Tumors

Lantern Pharma

NCT05933265

RECRUITING Phase 1 155 participants

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

Plexium

NCT07284186

RECRUITING Phase 1 154 participants

A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

Coherus Oncology

NCT06657144

RECRUITING Phase 1 148 participants

A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of BC3195 in Patients With Advanced or Metastatic Cancer

Biocity Biopharmaceutics Co.

NCT06548672

RECRUITING Phase 1 132 participants

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

MOMA Therapeutics

NCT06974110

RECRUITING Phase 1 130 participants

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Sairopa B.V.

NCT05856981

RECRUITING Phase 1 114 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours

Ipsen

NCT07213817

RECRUITING Phase 1 102 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

Ipsen

NCT07213830

RECRUITING Phase 1 101 participants

A Study of KK2269 in Adult Participants With Solid Tumors

Kyowa Kirin Co.

NCT06266299

RECRUITING Phase 1 97 participants

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Ankyra Therapeutics

NCT06171750

RECRUITING Phase 1 90 participants

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Clasp Therapeutics

NCT06778863

RECRUITING Phase 1 90 participants

A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

BeiGene

NCT06803680

RECRUITING Phase 1 80 participants

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Angiex

NCT06440005

RECRUITING Phase 1 77 participants

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05004116

RECRUITING Phase 1 75 participants

A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors

Exelixis

NCT06952010

RECRUITING Phase 1 72 participants

Determine Safety & Recommended Phase 2 Dosing of Zeaxanthin Alone or in Combination w/Pembrolizumab in Patients With Metastatic Cancer

Valley Health System

NCT05232409

RECRUITING Phase 1 70 participants

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

Massachusetts General Hospital

NCT06302621

RECRUITING Phase 1 40 participants

A Study to Assess Safety and Efficacy of SOT201 in Patients With Advanced/Metastatic Cancer

SOTIO Biotech

NCT06163391

RECRUITING Phase 2 30 participants

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

M.D. Anderson Cancer Center

NCT05673928

RECRUITING Phase 1 30 participants

ACE2016 in Adult Subjects With Locally Advanced or Metastatic Solid Tumors Expressing Epidermal Growth Factor Receptor (EGFR)

Acepodia Biotech

NCT06415487

RECRUITING Phase 2 25 participants

Topical Tretinoin Prophylaxis for Anti-EGFR Induced Skin Toxicity in Patients With Solid Tumors

University of Utah

NCT06358677

RECRUITING Phase 1 24 participants

Combination Therapy in Cancers With Mutations in DNA Repair Genes

University of California, San Francisco

NCT05694715

ACTIVE NOT RECRUITING Phase 1 750 participants

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Eli Lilly and Company

NCT06607185

ACTIVE NOT RECRUITING Phase 1 320 participants

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Ascendis Pharma Oncology Division A/S

NCT05081609

ACTIVE NOT RECRUITING Phase 2 223 participants

Study of Sacituzumab Govitecan in Participants With Metastatic Solid Tumors

Gilead Sciences

NCT03964727

ACTIVE NOT RECRUITING Phase 1 220 participants

Study of ART6043 in Advanced/Metastatic Solid Tumors Patients

Artios Pharma

NCT05898399

ACTIVE NOT RECRUITING Phase 1 150 participants

Dose Escalation and Expansion Study of WTX-124 as Monotherapy and in Combination With Pembrolizumab (Pembro) in Patients With Selected Advanced or Metastatic Solid Tumors

Werewolf Therapeutics

NCT05479812

ACTIVE NOT RECRUITING Phase 1 144 participants

A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors

Deciphera Pharmaceuticals

NCT04892017

ACTIVE NOT RECRUITING Phase 1 113 participants

TAC T-cells for the Treatment of Claudin 18.2 Positive Solid Tumors (TACTIC-3)

Triumvira Immunologics

NCT05862324

ACTIVE NOT RECRUITING 72 participants

Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population

University of Oklahoma

NCT05863052

ACTIVE NOT RECRUITING Phase 1 54 participants

A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05678010

ACTIVE NOT RECRUITING Phase 1 50 participants

QUILT-3.076: Study of Autologous M-CENK in Subjects With Locally Advanced or Metastatic Solid Tumors

ImmunityBio

NCT04898543

ACTIVE NOT RECRUITING Phase 1 42 participants

Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS

Immunophotonics

NCT05688280

ACTIVE NOT RECRUITING Phase 1 40 participants

A Study Evaluating DS-1055a in Participants With Relapsed or Refractory Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT04419532

ACTIVE NOT RECRUITING Phase 1 30 participants

A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of Oral TACH101 in Participants With Advanced or Metastatic Cancer

Tachyon Therapeutics

NCT05076552

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 3

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Solid Tumor Trial Landscape

53 indexed Metastatic Solid Tumor studies · 37 recruiting (70%).

Phase mix: 0 late (III/IV) vs 50 early (I/II).

Top sponsor: Eli Lilly and Company (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Solid Tumor?

PlainTrial tracks 53 US clinical trials for Metastatic Solid Tumor, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Solid Tumor?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.