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Study of LP-184 in Patients With Advanced Solid Tumors
NCT05933265 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of this study is to evaluate the safety, tolerability, MTD and RP2D of LP-184 in patients with advanced solid tumors who have relapsed from or are refractory to standard therapy or for whom no standard therapy is available. The secondary objectives are to characterize the PK of LP-184 and its metabolites in plasma and assess clinical activity of LP-184. Participants will receive LP-184 infusion during Day 1 and Day 8 of each 21-day cycle, for a minimum of two cycles. Patients will be monitored for safety, PK, and clinical activity
Conditions Studied
Interventions
- DRUG Olaparib
- DRUG Spironolactone
- DRUG LP-184
Study Locations (9)
Arkansas
- Highlands Oncology Group — Springdale
California
- Cancer and Blood Specialty Clinic — Los Alamitos
Illinois
- Northwest Oncology & Hematology — Rolling Meadows
Indiana
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis
Kentucky
- Norton Healthcare, Inc. — Louisville
Maryland
- John Hopkins - The Sidney Kimmel Comprehensive Cancer Center — Baltimore
Pennsylvania
- Fox Chase Cancer Center — Philadelphia
Texas
- UT Health Science Center San Antonio — San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 175 participants |
| Start Date | 2023-06-09 |
| Est. Completion | 2025-09-09 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05933265
The ClinicalTrials.gov registry entry for NCT05933265 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 175 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Lantern Pharma, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions — of which Olaparib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05933265 reports 9 study locations spanning 9 distinct geographic areas — top geographies include Arkansas, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05933265 about?
NCT05933265 is a clinical study titled "Study of LP-184 in Patients With Advanced Solid Tumors". The primary objective of this study is to evaluate the safety, tolerability, MTD and RP2D of LP-184 in patients with advanced solid tumors who have relapsed from or are refractory to standard therapy or for whom no standard therapy is available. The secondary objectives are to characterize the PK of...
What is the current status of trial NCT05933265?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 175 participants. The study started on 2023-06-09. Estimated completion is 2025-09-09.
What conditions does trial NCT05933265 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, NSCLC, Pancreatic Adenocarcinoma, Metastatic Solid Tumor, GBM. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05933265?
The interventions under investigation include: Olaparib (DRUG), Spironolactone (DRUG), LP-184 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05933265?
This trial is sponsored by Lantern Pharma, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05933265 being conducted?
This trial has 9 study locations across Arkansas, California, Illinois, Indiana, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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