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Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors
NCT05856981 · View on ClinicalTrials.gov ↗
Study Summary
This first-in-human, open-label, multicenter, multi-arm dose-escalation study is designed to evaluate the safety, PK, and PD of ADU-1805, an anti- SIRPα monoclonal antibody, as monotherapy and in combination with pembrolizumab (anti-PD-1 antibody).
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG ADU-1805
Study Locations (7)
Other
- Grand Hopital de Charleroi (GHdC) - Hopital Notre Dame — Charleroi
- Hosp 12 de Octubre — Madrid
- Hospital General Universitario Gergorio Maranon — Madrid
Michigan
- Henry Ford Cancer Institute — Detroit
Missouri
- Washington University Medical Campus — St Louis
Ohio
- Gabrail Cancer & Research Center — Canton
Virginia
- Virginia Cancer Specialists — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2023-04-03 |
| Est. Completion | 2027-07 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05856981
The ClinicalTrials.gov registry entry for NCT05856981 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sairopa B.V., which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Endometrial Cancer appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05856981 reports 7 study locations spanning 5 distinct geographic areas — top geographies include Other, Michigan, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05856981 about?
NCT05856981 is a clinical study titled "Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors". This first-in-human, open-label, multicenter, multi-arm dose-escalation study is designed to evaluate the safety, PK, and PD of ADU-1805, an anti- SIRPα monoclonal antibody, as monotherapy and in combination with pembrolizumab (anti-PD-1 antibody).
What is the current status of trial NCT05856981?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 130 participants. The study started on 2023-04-03. Estimated completion is 2027-07.
What conditions does trial NCT05856981 study?
This clinical trial studies the following conditions: Endometrial Cancer, Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer, NSCLC (Advanced Non-small Cell Lung Cancer). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05856981?
The interventions under investigation include: Pembrolizumab (DRUG), ADU-1805 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05856981?
This trial is sponsored by Sairopa B.V., which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05856981 being conducted?
This trial has 7 study locations across Michigan, Missouri, Ohio, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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