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A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors
NCT06607185 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally advanced or metastatic solid tumors with certain KRAS mutations. LY4066434 will be given alone or in combination with other treatments. The study will have 2 parts: monotherapy dose escalation and dose optimization. The study is expected to last up to approximately 5 years.
Conditions Studied
Interventions
- DRUG Oxaliplatin
- DRUG Cetuximab
- DRUG Gemcitabine
- DRUG Nab paclitaxel
- DRUG LY4066434.
Study Locations (20)
California
- City of Hope — Duarte
- University of California, Los Angeles (UCLA) — Los Angeles
Massachusetts
- Massachusetts General Hospital — Boston
- Dana-Farber Cancer Institute — Boston
Michigan
- Henry Ford Health System — Detriot
- South Texas Accelerated Research Therapeutics (START) Midwest — Grand Rapids
New York
- Columbia University — New York
- David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center — New York
Alabama
- University of Alabama at Birmingham — Birmingham
Arizona
- Mayo Clinic — Phoenix
Colorado
- University of Colorado Denver — Denver
Connecticut
- Yale University School of Medicine - Yale Cancer Center — New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 750 participants |
| Start Date | 2024-10-21 |
| Est. Completion | 2030-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06607185
The ClinicalTrials.gov registry entry for NCT06607185 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 750 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 5 interventions — of which Oxaliplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06607185 reports 20 study locations spanning 16 distinct geographic areas — top geographies include California, Massachusetts, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06607185 about?
NCT06607185 is a clinical study titled "A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors". The main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally advanced or metastatic solid tumors with certain KRAS mutations. LY4066434 will be given alone or in combination with other treatments. The study will ha...
What is the current status of trial NCT06607185?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 750 participants. The study started on 2024-10-21. Estimated completion is 2030-01.
What conditions does trial NCT06607185 study?
This clinical trial studies the following conditions: Colorectal Cancer, Advanced Solid Tumor, Non-small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Metastatic Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06607185?
The interventions under investigation include: Oxaliplatin (DRUG), Cetuximab (DRUG), Gemcitabine (DRUG), Nab paclitaxel (DRUG), LY4066434. (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06607185?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06607185 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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