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NCT06657144 · ClinicalTrials.gov registry record · Phase 1

A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

A Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor, sponsored by Coherus Oncology.

Recruiting
Registry status
Phase 1
Development phase
154
Enrollment target
20
Study locations

NCT06657144: Recruiting Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor, sponsored by Coherus Oncology.

NCT06657144 is a Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor that is actively recruiting participants, run by Coherus Oncology. The registered enrollment target is 154 participants, below the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (20% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06657144, a Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor, is actively recruiting participants, sponsored by Coherus Oncology.

RECRUITING
Registry status
Phase 1
Development phase
154 participants
Enrollment target
20
Study locations

Study Summary

The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

Conditions Studied

Advanced Solid Tumor Metastatic Solid Tumor

Interventions

  • DRUG Cisplatin
  • DRUG Toripalimab
  • DRUG CHS-114
  • DRUG 5 Fluorouracil

Study Locations (20)

New York

  • START New York - Lake Success
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center - New York
  • Icahn School of Medicine at Mount Sinai - New York

Texas

  • Texas Oncology - Central South - Austin
  • START San Antonio, LLC. - San Antonio

Utah

  • Huntsman Cancer Institute, University of Utah - Salt Lake City
  • START Mountain Region, LLC. - West Valley City

Virginia

  • Virginia Cancer Specialists - Fairfax
  • Virginia Oncology Associates - Norfolk

Arizona

  • The University of Arizona Cancer Center - Tucson

California

  • City of Hope - Duarte

Colorado

  • University of Colorado - Aurora Cancer Center - Aurora

Georgia

  • Winship Cancer Center - Emory University - Atlanta

Trial Details

FieldValue
Enrollment Target 154 participants
Start Date 2025-04-01
Est. Completion 2027-05
Phase Phase 1
Coherus Oncology

15 total trials

What NCT06657144 shows while recruiting

NCT06657144 is an interventional study that assigns participants to a tested intervention. The registered 154 participants enrollment target is mid-sized for trials with a published cap, below the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (20% lower).

The record links to 2 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 4 interventions - of which Cisplatin is the first listed.

NCT06657144 names 20 study sites across 15 states, led by New York, Texas, Utah.

Frequently Asked Questions

What is clinical trial NCT06657144 about?

NCT06657144 is a clinical study titled "A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors". The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

What is the current status of trial NCT06657144?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 154 participants. The study started on 2025-04-01. Estimated completion is 2027-05.

What conditions does trial NCT06657144 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Metastatic Solid Tumor.

What interventions are being tested in trial NCT06657144?

The interventions under investigation include: Cisplatin (DRUG), Toripalimab (DRUG), CHS-114 (DRUG), 5 Fluorouracil (DRUG).

Who is sponsoring clinical trial NCT06657144?

This trial is sponsored by Coherus Oncology, which has 15 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06657144 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Georgia, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Advanced Solid Tumor

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06657144's enrollment target sits among peer trials

154 84th of 189 higher than 106 of 189 other Advanced Solid Tumor trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT06657144

Source: ClinicalTrials.gov NCT06657144, the US trial registry maintained by the National Library of Medicine. NCT06657144 (mid enrollment · wide site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.