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NCT06657144 · ClinicalTrials.gov registry record · Phase 1

A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

A Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor, sponsored by Coherus Oncology.

Recruiting
Registry status
Phase 1
Development phase
154
Enrollment target
20
Study locations

NCT06657144 is a Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor that is actively recruiting participants, run by Coherus Oncology. The registered enrollment target is 154 participants, below the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (20% lower). The trial reports 20 study locations across 15 states.

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The verdict

NCT06657144, a Phase 1 study of Advanced Solid Tumor and Metastatic Solid Tumor, is actively recruiting participants, sponsored by Coherus Oncology.

RECRUITING
Registry status
Phase 1
Development phase
154 participants
Enrollment target
20
Study locations

Study Summary

The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

Conditions Studied

Advanced Solid Tumor Metastatic Solid Tumor

Interventions

  • DRUG Cisplatin
  • DRUG Toripalimab
  • DRUG CHS-114
  • DRUG 5 Fluorouracil

Study Locations (20)

New York

  • START New York - Lake Success
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center - New York
  • Icahn School of Medicine at Mount Sinai - New York

Texas

  • Texas Oncology - Central South - Austin
  • START San Antonio, LLC. - San Antonio

Utah

  • Huntsman Cancer Institute, University of Utah - Salt Lake City
  • START Mountain Region, LLC. - West Valley City

Virginia

  • Virginia Cancer Specialists - Fairfax
  • Virginia Oncology Associates - Norfolk

Arizona

  • The University of Arizona Cancer Center - Tucson

California

  • City of Hope - Duarte

Colorado

  • University of Colorado - Aurora Cancer Center - Aurora

Georgia

  • Winship Cancer Center - Emory University - Atlanta

Trial Details

FieldValue
Enrollment Target 154 participants
Start Date 2025-04-01
Est. Completion 2027-05
Phase Phase 1

Sponsor

Coherus Oncology

15 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06657144

The ClinicalTrials.gov registry entry for NCT06657144 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 154 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (20% lower). The listed sponsor is Coherus Oncology, which has 15 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 4 interventions - of which Cisplatin is the first listed.

NCT06657144 reports 20 study locations spanning 15 distinct geographic areas - top geographies include New York, Texas, Utah.

Frequently Asked Questions

What is clinical trial NCT06657144 about?

NCT06657144 is a clinical study titled "A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors". The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

What is the current status of trial NCT06657144?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 154 participants. The study started on 2025-04-01. Estimated completion is 2027-05.

What conditions does trial NCT06657144 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Metastatic Solid Tumor.

What interventions are being tested in trial NCT06657144?

The interventions under investigation include: Cisplatin (DRUG), Toripalimab (DRUG), CHS-114 (DRUG), 5 Fluorouracil (DRUG).

Who is sponsoring clinical trial NCT06657144?

This trial is sponsored by Coherus Oncology, which has 15 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06657144 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Georgia, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.