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RECRUITING Phase 1

A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

NCT06657144 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

Interventions

  • DRUG Cisplatin
  • DRUG Toripalimab
  • DRUG CHS-114
  • DRUG 5 Fluorouracil

Study Locations (20)

New York

  • START New York — Lake Success
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center — New York
  • Icahn School of Medicine at Mount Sinai — New York

Texas

  • Texas Oncology - Central South — Austin
  • START San Antonio, LLC. — San Antonio

Utah

  • Huntsman Cancer Institute, University of Utah — Salt Lake City
  • START Mountain Region, LLC. — West Valley City

Virginia

  • Virginia Cancer Specialists — Fairfax
  • Virginia Oncology Associates — Norfolk

Arizona

  • The University of Arizona Cancer Center — Tucson

California

  • City of Hope — Duarte

Colorado

  • University of Colorado - Aurora Cancer Center — Aurora

Georgia

  • Winship Cancer Center - Emory University — Atlanta

Trial Details

FieldValue
Enrollment Target 154 participants
Start Date 2025-04-01
Est. Completion 2027-05
Phase Phase 1

Sponsor

Coherus Oncology

32 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06657144

The ClinicalTrials.gov registry entry for NCT06657144 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 154 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Coherus Oncology, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 4 interventions — of which Cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06657144 reports 20 study locations spanning 15 distinct geographic areas — top geographies include New York, Texas, Utah. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06657144 about?

NCT06657144 is a clinical study titled "A Study of CHS-114 in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors". The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.

What is the current status of trial NCT06657144?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 154 participants. The study started on 2025-04-01. Estimated completion is 2027-05.

What conditions does trial NCT06657144 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Metastatic Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06657144?

The interventions under investigation include: Cisplatin (DRUG), Toripalimab (DRUG), CHS-114 (DRUG), 5 Fluorouracil (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06657144?

This trial is sponsored by Coherus Oncology, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06657144 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Georgia, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial