Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

NCT06974110 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 1, multi-center, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and preliminary clinical activity of MOMA-341 administered orally as a single agent or combination therapy in patients with microsatellite instability high (MSI-H) or DNA mismatch repair deficiency (dMMR) solid tumors.

Interventions

  • DRUG Irinotecan
  • DRUG Immunotherapy
  • DRUG MOMA-341

Study Locations (13)

Texas

  • Investigative Site #127 — Dallas
  • Investigative Site #129 — Houston

New South Wales

  • Investigative Site #122 — Sydney
  • Investigative Site #123 — Westmead

Florida

  • Investigative Site #128 — Tampa

Michigan

  • Investigative Site #120 — Detroit

Missouri

  • Investigative Site #110 — St Louis

North Carolina

  • Investigative Site #131 — Raleigh

Oregon

  • Investigative Site #121 — Portland

Queensland

  • Investigative Site #124 — Woolloongabba

Trial Details

FieldValue
Enrollment Target 132 participants
Start Date 2025-07-16
Est. Completion 2028-05
Phase Phase 1

Sponsor

MOMA Therapeutics

33 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06974110

The ClinicalTrials.gov registry entry for NCT06974110 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 132 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is MOMA Therapeutics, which has 33 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 7 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 3 interventions — of which Irinotecan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06974110 reports 13 study locations spanning 11 distinct geographic areas — top geographies include Texas, New South Wales, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06974110 about?

NCT06974110 is a clinical study titled "Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors". This Phase 1, multi-center, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and preliminary clinical activity of MOMA-341 administered orally as a single agent or combination therapy in patients wi...

What is the current status of trial NCT06974110?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 132 participants. The study started on 2025-07-16. Estimated completion is 2028-05.

What conditions does trial NCT06974110 study?

This clinical trial studies the following conditions: Colorectal Cancer, Advanced Solid Tumor, Endometrial Cancer, Gastric Cancer, Metastatic Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06974110?

The interventions under investigation include: Irinotecan (DRUG), Immunotherapy (DRUG), MOMA-341 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06974110?

This trial is sponsored by MOMA Therapeutics, which has 33 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06974110 being conducted?

This trial has 13 study locations across Florida, Michigan, Missouri, North Carolina, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial