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ClinicalTrials.gov 25 recruiting now official registry

Metabolic Disease clinical trials

25 of 34 indexed Metabolic Disease trials are currently recruiting.

34 US clinical trials · 25 currently recruiting

Metabolic Disease is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 25 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan, running 4 of these trials.

The research picture

Metabolic Disease has 34 registered US clinical trials, 25 of them open to new participants right now, about 74% of the total.

25
recruiting participants now
74%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: University of Michigan
Phase 24

Active & Recent Trials

34 total, page 1 of 1

RECRUITING 100,000 participants

An Observational Study On TheAccuracy Of Whole-Body Magnetic Resonance Imaging (Wb-Mri) ScreeningTo Predict Clinically Significant Diagnoses In General Population Subjects Interested In Proactive And Advanced General Preventive Healthcare.

Hercules

NCT06212479

RECRUITING 15,000 participants

Evaluation of Children With Endocrine and Metabolic-Related Conditions

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT02769975

RECRUITING 10,000 participants

Cardiovascular and Metabolic Sciences Biorepository

The Cleveland Clinic

NCT06560424

RECRUITING 5,000 participants

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

National Heart, Lung, and Blood Institute (NHLBI)

NCT01143454

RECRUITING 2,000 participants

Rare and Atypical Diabetes Network

University of South Florida

NCT05544266

RECRUITING 2,000 participants

Natural History of the Human Biological Response to Environmental Exposure and Injury

National Institute of Environmental Health Sciences (NIEHS)

NCT04888923

RECRUITING 1,045 participants

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

National Human Genome Research Institute (NHGRI)

NCT02890342

RECRUITING 500 participants

Vascular Lab Resource (VLR) Biorepository

The Cleveland Clinic

NCT05628948

RECRUITING NA 300 participants

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Colorado State University

NCT05543083

RECRUITING 240 participants

Alzheimer"s Imaging Biomarkers in Obesity

Cyrus A Raji

NCT05077579

RECRUITING Phase 2 200 participants

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

University of Alabama at Birmingham

NCT04055428

RECRUITING 175 participants

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

University of Michigan

NCT06007404

RECRUITING NA 167 participants

Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

University of California, Los Angeles

NCT05516277

RECRUITING NA 120 participants

Thermogenic Silencer Regulatory Factors in Humans

Rockefeller University

NCT06424132

RECRUITING NA 120 participants

Gut Microbiota-dependent Health Impacts of Haskap Berries

Montana State University

NCT06546020

RECRUITING Phase 2 80 participants

Improving Coronary Vascular Health in Women

Massachusetts General Hospital

NCT06843902

RECRUITING NA 68 participants

Metabolic Adaptations to Weight Loss With and Without Exercise

University of Michigan

NCT05806801

RECRUITING NA 60 participants

HIIT Effects on Cardiometabolic Health

Syracuse University

NCT05838950

RECRUITING NA 60 participants

In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes

Cornell University

NCT06557317

RECRUITING NA 50 participants

Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers

Colorado State University

NCT06550115

RECRUITING NA 46 participants

Exercise Effects on Adipose Tissue Structure and Function

University of Michigan

NCT04812314

RECRUITING NA 32 participants

Countermeasures to Circadian Misalignment

Colorado State University

NCT04966351

RECRUITING 30 participants

Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

Christopher C. Thompson, MD, MSc

NCT05711758

RECRUITING 19 participants

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT05600946

RECRUITING Phase 2 17 participants

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children

Johns Hopkins All Children's Hospital

NCT04414046

ACTIVE NOT RECRUITING NA 60 participants

Sleep and Vascular Health Study

Auburn University

NCT05918744

ACTIVE NOT RECRUITING 50 participants

MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus

University of Colorado, Denver

NCT03945747

ACTIVE NOT RECRUITING NA 10 participants

Pilot Haskap Metabolite Timing Project

Montana State University

NCT06938386

COMPLETED 628 participants

Evaluation of the Analytical Performance of ALLEGRO™ Instrument

Nova Biomedical

NCT04096313

COMPLETED 80 participants

Metabolic Abnormalities in Children With Epilepsy

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001325

COMPLETED NA 31 participants

Mitochondrial Remodeling After Exercise

Oregon State University

NCT04103424

COMPLETED NA 24 participants

mTORC1 and Autophagy in Human Brown Adipocytes

University of New Mexi

NCT04206124

COMPLETED NA 22 participants

Effects of Exercise and Energy Balance on 24-hour Blood Glucose Control

University of Michigan

NCT03350997

COMPLETED Phase 2 19 participants

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02019667

Phase Distribution

PhaseTrial count
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metabolic Disease Trial Landscape

34 indexed Metabolic Disease studies · 25 recruiting (74%).

Phase mix: 0 late (III/IV) vs 4 early (I/II).

Top sponsor: University of Michigan (4 trials), 9 others listed. 34 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metabolic Disease?

PlainTrial tracks 34 US clinical trials for Metabolic Disease, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metabolic Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.