Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Metabolic Disease
Open-data reference.
34 US clinical trials · 25 currently recruiting
Active & Recent Trials
An Observational Study On TheAccuracy Of Whole-Body Magnetic Resonance Imaging (Wb-Mri) ScreeningTo Predict Clinically Significant Diagnoses In General Population Subjects Interested In Proactive And Advanced General Preventive Healthcare.
Hercules
NCT06212479
Evaluation of Children With Endocrine and Metabolic-Related Conditions
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT02769975
Cardiovascular and Metabolic Sciences Biorepository
The Cleveland Clinic
NCT06560424
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
National Heart, Lung, and Blood Institute (NHLBI)
NCT01143454
Rare and Atypical Diabetes Network
University of South Florida
NCT05544266
Natural History of the Human Biological Response to Environmental Exposure and Injury
National Institute of Environmental Health Sciences (NIEHS)
NCT04888923
Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia
National Human Genome Research Institute (NHGRI)
NCT02890342
Vascular Lab Resource (VLR) Biorepository
The Cleveland Clinic
NCT05628948
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Alzheimer"s Imaging Biomarkers in Obesity
Cyrus A Raji
NCT05077579
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
University of Alabama at Birmingham
NCT04055428
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
University of California, Los Angeles
NCT05516277
Thermogenic Silencer Regulatory Factors in Humans
Rockefeller University
NCT06424132
Gut Microbiota-dependent Health Impacts of Haskap Berries
Montana State University
NCT06546020
Improving Coronary Vascular Health in Women
Massachusetts General Hospital
NCT06843902
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
HIIT Effects on Cardiometabolic Health
Syracuse University
NCT05838950
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Cornell University
NCT06557317
Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
Colorado State University
NCT06550115
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Countermeasures to Circadian Misalignment
Colorado State University
NCT04966351
Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure
Christopher C. Thompson, MD, MSc
NCT05711758
Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT05600946
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children
Johns Hopkins All Children's Hospital
NCT04414046
Sleep and Vascular Health Study
Auburn University
NCT05918744
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
University of Colorado, Denver
NCT03945747
Pilot Haskap Metabolite Timing Project
Montana State University
NCT06938386
Evaluation of the Analytical Performance of ALLEGRO™ Instrument
Nova Biomedical
NCT04096313
Metabolic Abnormalities in Children With Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001325
Mitochondrial Remodeling After Exercise
Oregon State University
NCT04103424
mTORC1 and Autophagy in Human Brown Adipocytes
University of New Mexi
NCT04206124
Effects of Exercise and Energy Balance on 24-hour Blood Glucose Control
University of Michigan
NCT03350997
Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02019667
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Metabolic Disease Trial Landscape
ClinicalTrials.gov lists 34 US studies indexed under Metabolic Disease, and 25 of those are currently open to recruitment — roughly 74% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Metabolic Disease shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Metabolic Disease is led by University of Michigan with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 34 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Metabolic Disease?
PlainTrial tracks 34 US clinical trials for Metabolic Disease, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Metabolic Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.