Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Metabolic Disease: early-phase trial registry
25 of 34 indexed Metabolic Disease trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #451 of 28,707 conditions by registered trial count.
34 US clinical trials · 25 currently recruiting · #451 of 28,707 conditions by registered trial count
Metabolic Disease: 34 US clinical trials tracked, 25 recruiting.
Metabolic Disease is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 25 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is University of Michigan, running 4 of these trials.
Enrollment posture brief
Registry condition metabolic-disease
OPEN 25 | RECR 74% | LATE 0 | EARLY 4 | RANK #451 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Mental Health Issue (74% recruiting · 53 trials)
Metabolic Disease lists 25 open slots (74% of 34 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Metabolic Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Metabolic Disease is recruiting above its size-band peers.
25 of 34 indexed trials (73.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Metabolic Disease trials is spread across many organizations.
University of Michigan accounts for 4 of 34 trials (11.8%). 25 distinct sponsors appear on at least one study for this condition label.
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Typical Metabolic Disease enrolment sits around 80 participants.
Median target enrolment is 80 among the 34 trials that report a genuine target (sentinel values excluded). 18 of those (52.9%) plan for fewer than 100 participants.
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Metabolic Disease splits between interventional and observational designs.
19 interventional and 15 observational studies make up this index (55.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
34 total, page 1 of 1
An Observational Study On TheAccuracy Of Whole-Body Magnetic Resonance Imaging (Wb-Mri) ScreeningTo Predict Clinically Significant Diagnoses In General Population Subjects Interested In Proactive And Advanced General Preventive Healthcare.
Hercules
NCT06212479
Evaluation of Children With Endocrine and Metabolic-Related Conditions
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT02769975
Cardiovascular and Metabolic Sciences Biorepository
The Cleveland Clinic
NCT06560424
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
National Heart, Lung, and Blood Institute (NHLBI)
NCT01143454
Rare and Atypical Diabetes Network
University of South Florida
NCT05544266
Natural History of the Human Biological Response to Environmental Exposure and Injury
National Institute of Environmental Health Sciences (NIEHS)
NCT04888923
Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia
National Human Genome Research Institute (NHGRI)
NCT02890342
Vascular Lab Resource (VLR) Biorepository
The Cleveland Clinic
NCT05628948
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Colorado State University
NCT05543083
Alzheimer"s Imaging Biomarkers in Obesity
Cyrus A Raji
NCT05077579
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
University of Alabama at Birmingham
NCT04055428
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
University of California, Los Angeles
NCT05516277
Thermogenic Silencer Regulatory Factors in Humans
Rockefeller University
NCT06424132
Gut Microbiota-dependent Health Impacts of Haskap Berries
Montana State University
NCT06546020
Improving Coronary Vascular Health in Women
Massachusetts General Hospital
NCT06843902
Metabolic Adaptations to Weight Loss With and Without Exercise
University of Michigan
NCT05806801
HIIT Effects on Cardiometabolic Health
Syracuse University
NCT05838950
In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes
Cornell University
NCT06557317
Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
Colorado State University
NCT06550115
Exercise Effects on Adipose Tissue Structure and Function
University of Michigan
NCT04812314
Countermeasures to Circadian Misalignment
Colorado State University
NCT04966351
Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure
Christopher C. Thompson, MD, MSc
NCT05711758
Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT05600946
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children
Johns Hopkins All Children's Hospital
NCT04414046
Sleep and Vascular Health Study
Auburn University
NCT05918744
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
University of Colorado, Denver
NCT03945747
Pilot Haskap Metabolite Timing Project
Montana State University
NCT06938386
Evaluation of the Analytical Performance of ALLEGRO™ Instrument
Nova Biomedical
NCT04096313
Metabolic Abnormalities in Children With Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00001325
Mitochondrial Remodeling After Exercise
Oregon State University
NCT04103424
mTORC1 and Autophagy in Human Brown Adipocytes
University of New Mexi
NCT04206124
Effects of Exercise and Energy Balance on 24-hour Blood Glucose Control
University of Michigan
NCT03350997
Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency
National Institute of Neurological Disorders and Stroke (NINDS)
NCT02019667
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Metabolic Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Metabolic Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Metabolic Disease page
34 registered trials, 25 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 25 Metabolic Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Michigan sponsors the most Metabolic Disease trials on record, review their full trial history before evaluating a specific study. See University of Michigan's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Metabolic Disease condition card totals 34 registered trials; most-linked intervention Brown Fat Harvest During Anterior Neck Surgery; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.