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NCT00001325 · ClinicalTrials.gov registry record

Metabolic Abnormalities in Children With Epilepsy

A clinical trial of Seizures and Metabolic Disease, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

Completed
Registry status
80
Enrollment target
1
Study location

NCT00001325: Completed study of Seizures and Metabolic Disease, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

NCT00001325 is a study of Seizures and Metabolic Disease that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 80 participants, below the 933-participant average among 39 other Seizures trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00001325, a study of Seizures and Metabolic Disease, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).

COMPLETED
Registry status
80 participants
Enrollment target
1
Study location

Study Summary

This study is designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Researchers can label a sugar with a small radioactive molecule called FDG (fluorodeoxyglucose). As areas of the brain use more sugar the PET scan will detect the FDG and show the areas of the brain that are active. By using this technique researchers hope to answer the following questions; 4\. Are changes in brain energy use (metabolism) present early in the course of epilepsy 5\. Do changes in brain metabolism match the severity of patient's seizures 6\. Do changes in metabolism occur over time or in response to drug therapy

Conditions Studied

Seizures Metabolic Disease Partial Epilepsy Infantile Spasms Generalized Epilepsy

Interventions

  • DRUG 18 FDG

Study Locations (1)

Maryland

  • National Institute of Neurological Disorders and Stroke (NINDS) - Bethesda

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 1992-04
Est. Completion 2004-06
National Institute of Neurological Disorders and Stroke (NINDS)

567 total trials

What the finished NCT00001325 record still lists

NCT00001325 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 933-participant average among 39 other Seizures trials with a reported enrollment target (91% lower).

The record links to 5 conditions, with Seizures appearing as the primary indexed condition, and to 1 intervention - of which 18 FDG is the first listed.

NCT00001325 reports a single indexed study location in Maryland.

Frequently Asked Questions

What is clinical trial NCT00001325 about?

NCT00001325 is a clinical study titled "Metabolic Abnormalities in Children With Epilepsy". This study is designed to use positron emission tomography to measure brain energy use. Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of ...

What is the current status of trial NCT00001325?

This trial is currently completed. The enrollment target is 80 participants. The study started on 1992-04. Estimated completion is 2004-06.

What conditions does trial NCT00001325 study?

This clinical trial studies the following conditions: Seizures, Metabolic Disease, Partial Epilepsy, Infantile Spasms, Generalized Epilepsy.

What interventions are being tested in trial NCT00001325?

The interventions under investigation include: 18 FDG (DRUG).

Who is sponsoring clinical trial NCT00001325?

This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00001325 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Seizures

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00001325's enrollment target sits among peer trials

80 19th of 39 higher than 21 of 39 other Seizures trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Seizures trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT00001325, the US trial registry maintained by the National Library of Medicine. NCT00001325 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.