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NCT04206124 · ClinicalTrials.gov registry record · NA
mTORC1 and Autophagy in Human Brown Adipocytes
A NA study of Obesity and Metabolic Disease, sponsored by University of New Mexi.
- Completed
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT04206124: Completed NA study of Obesity and Metabolic Disease, sponsored by University of New Mexi.
NCT04206124 is a NA study of Obesity and Metabolic Disease that has completed, run by University of New Mexi. The registered enrollment target is 24 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04206124, a NA study of Obesity and Metabolic Disease, has completed, sponsored by University of New Mexi.
- COMPLETED
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
The long term goal is to identify the potential therapeutic targets for the treatment of obesity and its associated disorders by studying the driving factors of activation of brown adipose tissue (BAT) in human adults. Whereas activation of brown adipose tissue (BAT) in human adults has been considered as a potential therapeutic target to battle obesity since it was identified in 2009, the underlying mechanisms of beige adipocytes appearance in human adults is unclear. The objective of this proposal is to investigate the role of autophagy in mediating the inhibitory effect of mammalian target of rapamycin complex 1 (mTORC1) in regulating human brown adipocytes. The central hypothesis is that autophagy plays a critical role in regulating browning of white adipose tissue and mediates the beneficial effect of mTORC1 inhibition on thermogenesis in human brown adipocytes.
Primary Outcome
Human brown adipose tissue (BAT) samples will be collected during previously scheduled anterior neck surgery and then cultured and amplified for experiments including Western Blot (WB), an assay to quantify the relative amounts of protein present in a sample. WB will be used to determine how protein expression levels differ between lean and obese BAT samples. Specifically, the translational levels of key markers of mTOR signaling including UCP1, C/EBPβ, HSL, S6K, ADPN, PKA, AMPK and ATGL will b
Conditions Studied
Interventions
- PROCEDURE Brown Fat Harvest During Anterior Neck Surgery
Study Locations (1)
New Mexico
- University of New Mexico Health Sciences Center - Albuquerque
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2016-11-01 |
| Est. Completion | 2020-09-30 |
| Phase | NA |
What the finished NCT04206124 record still lists
NCT04206124 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which Brown Fat Harvest During Anterior Neck Surgery is the first listed.
NCT04206124 reports a single indexed study location in New Mexico.
Frequently Asked Questions
What is clinical trial NCT04206124 about?
NCT04206124 is a clinical study titled "mTORC1 and Autophagy in Human Brown Adipocytes". The long term goal is to identify the potential therapeutic targets for the treatment of obesity and its associated disorders by studying the driving factors of activation of brown adipose tissue (BAT) in human adults. Whereas activation of brown adipose tissue (BAT) in human adults has been conside...
What is the current status of trial NCT04206124?
This trial is currently completed. It is a NA study. The enrollment target is 24 participants. The study started on 2016-11-01. Estimated completion is 2020-09-30.
What conditions does trial NCT04206124 study?
This clinical trial studies the following conditions: Obesity, Metabolic Disease.
What interventions are being tested in trial NCT04206124?
The interventions under investigation include: Brown Fat Harvest During Anterior Neck Surgery (PROCEDURE).
Who is sponsoring clinical trial NCT04206124?
This trial is sponsored by University of New Mexi, which has 76 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04206124 being conducted?
This trial has 1 study location across New Mexico. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04206124's enrollment target sits among peer trials
24 909th of 1053 higher than 127 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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