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NCT05077579 · ClinicalTrials.gov registry record
Alzheimer"s Imaging Biomarkers in Obesity
A clinical trial of Obesity and Alzheimer Disease, sponsored by Cyrus A Raji.
- Recruiting
- Registry status
- 240
- Enrollment target
- 1
- Study location
NCT05077579 is a study of Obesity and Alzheimer Disease that is actively recruiting participants, run by Cyrus A Raji. The registered enrollment target is 240 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05077579, a study of Obesity and Alzheimer Disease, is actively recruiting participants, sponsored by Cyrus A Raji.
- RECRUITING
- Registry status
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
High body fat at midlife, as evidenced by overweight or obese body mass index (BMI), is increasingly understood as a risk factor for Alzheimer's disease. However, the underlying processes and mechanisms that may underlie this risk remains unknown. With this project, the Investigator proposes to create a new cohort of cognitively normal 120 midlife individuals, age 40-60 years. The investigator and research staff will characterize the participant's overweight or obese status using metabolic tests including, an oral glucose tolerance test, fasting plasma insulin, fasting plasma glucose, and hemoglobin A1c measurements. This testing will generate categories of metabolically abnormal overweight and obese (MAOO), metabolically normal overweight and obese (MNOO), and metabolically normal lean participants (MNLP). Research staff will evaluate differences between these groups on neuroimaging with the newer classification framework of Alzheimer's biomarkers with amyloid (A), tau (T), and neurodegeneration (N), or ATN. Neurodegeneration will be assessed by atrophy on brain MRI as reflected by regional volumes on Freesurfer. Staff will also evaluate MR neuroimaging markers for neuroinflammation using a newer method called diffusion basis spectrum imaging (DBSI), developed at the Mallinckrodt Institute of Radiology at Washington University in St. Louis in collaboration with The Charles F. and Joanne Knight Alzheimer's Disease Research Center (Knight ADRC).
Conditions Studied
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2021-10-18 |
| Est. Completion | 2026-12-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05077579
The ClinicalTrials.gov registry entry for NCT05077579 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (71% lower). The listed sponsor is Cyrus A Raji, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Obesity appearing as the primary indexed condition, and to 0 interventions.
NCT05077579 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT05077579 about?
NCT05077579 is a clinical study titled "Alzheimer"s Imaging Biomarkers in Obesity". High body fat at midlife, as evidenced by overweight or obese body mass index (BMI), is increasingly understood as a risk factor for Alzheimer's disease. However, the underlying processes and mechanisms that may underlie this risk remains unknown. With this project, the Investigator proposes to crea...
What is the current status of trial NCT05077579?
This trial is currently recruiting. The enrollment target is 240 participants. The study started on 2021-10-18. Estimated completion is 2026-12-31.
What conditions does trial NCT05077579 study?
This clinical trial studies the following conditions: Obesity, Alzheimer Disease, Metabolic Disease.
Who is sponsoring clinical trial NCT05077579?
This trial is sponsored by Cyrus A Raji, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05077579 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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