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NCT02890342 · ClinicalTrials.gov registry record
Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia
A clinical trial of Metabolic Disease and Propionic Acidemia, sponsored by National Human Genome Research Institute (NHGRI).
- Recruiting
- Registry status
- 1,045
- Enrollment target
- 2
- Study locations
NCT02890342: Recruiting study of Metabolic Disease and Propionic Acidemia, sponsored by National Human Genome Research Institute (NHGRI).
NCT02890342 is a study of Metabolic Disease and Propionic Acidemia that is actively recruiting participants, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 1,045 participants, below the 4,158-participant average among 33 other Metabolic Disease trials with a reported enrollment target (75% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02890342, a study of Metabolic Disease and Propionic Acidemia, is actively recruiting participants, sponsored by National Human Genome Research Institute (NHGRI).
- RECRUITING
- Registry status
- 1,045 participants
- Enrollment target
- 2
- Study locations
Study Summary
Background: People s bodies need to break down food into the chemicals. These chemicals are used for energy and growth. Some people cannot process all chemicals very well. Too much of some chemicals can cause diseases. One of these diseases is called propionic acidemia (PA). People with PA can have problems with growth, learning heart, abdomen, and other organs. Researchers want to better understand how these problems happen. Objective: To learn more about propionic acidemia and the genes that might contribute to it. Eligibility: People at least 2 years old with PA who can travel to the clinic Some unaffected family members Design: Participants will have a 3 to 5-day hospital visit every year or every few years. Family members may have just 1 visit. During the family member visit, they may have: Medical history Physical exam Samples of blood and urine Questions about diet and a food diary Doctors and nurses may do additional studies: Samples of saliva, skin and stool Fluid from a gastronomy tube, if participants have one Dental and eye evaluations A kidney test - a small amount of dye will be injected and blood will be collected. Consultations with specialists A test of calories needed at rest. A clear plastic tent is placed over the participant to measure breathing. Stable isotope study. Participants will take a nonradioactive substance then blow into a bag. Photos taken of the face and body with underwear on Ultrasound of the abdomen Heart tests Hand x-ray Brain scan Participants may have other tests if study doctors recommend them. They will get the results of standard medical tests and genetic tests.
Primary Outcome
assessing the long term complications of Propionic Acidemia during a week long evaluation with imaging, labs, and consultations.
Conditions Studied
Study Locations (2)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Pennsylvania
- Children's Hospital of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,045 participants |
| Start Date | 2016-11-29 |
| Est. Completion | 2036-08-31 |
What NCT02890342 shows while recruiting
NCT02890342 is an observational study that tracks outcomes without assigning an intervention. Its 1,045 participants enrollment target places it among the larger protocols in the corpus, below the 4,158-participant average among 33 other Metabolic Disease trials with a reported enrollment target (75% lower).
The record links to 3 conditions, with Metabolic Disease appearing as the primary indexed condition, and to 0 interventions.
NCT02890342 reports a single indexed study location in Maryland, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02890342 about?
NCT02890342 is a clinical study titled "Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia". Background: People s bodies need to break down food into the chemicals. These chemicals are used for energy and growth. Some people cannot process all chemicals very well. Too much of some chemicals can cause diseases. One of these diseases is called propionic acidemia (PA). People with PA can have...
What is the current status of trial NCT02890342?
This trial is currently recruiting. The enrollment target is 1,045 participants. The study started on 2016-11-29. Estimated completion is 2036-08-31.
What conditions does trial NCT02890342 study?
This clinical trial studies the following conditions: Metabolic Disease, Propionic Acidemia, Organic Acidemia.
Who is sponsoring clinical trial NCT02890342?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02890342 being conducted?
This trial has 2 study locations across Maryland, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metabolic Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02890342's enrollment target sits among peer trials
1,045 7th of 33 higher than 27 of 33 other Metabolic Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metabolic Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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