Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Dry Eye Disease clinical trials
5 of 34 indexed Dry Eye Disease trials are currently recruiting.
34 US clinical trials · 5 currently recruiting
Dry Eye Disease is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Bausch & Lomb Incorporated, running 3 of these trials.
The research picture
Dry Eye Disease has 34 registered US clinical trials, 5 of them open to new participants right now, about 15% of the total.
- 5
- recruiting participants now
- 15%
- of trials open to enrollment
- 12
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Bausch & Lomb Incorporated
Active & Recent Trials
34 total, page 1 of 1
A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease
Bausch & Lomb Incorporated
NCT07128628
A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment
Hoffmann-La Roche
NCT07025811
A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease
AbbVie
NCT07284381
2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD
University of Maryland, Baltimore
NCT04946721
Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).
Instituto Grifols, S.A.
NCT07264517
A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease
Telios Pharma
NCT06225973
A Phase 3 Study to Evaluate AZR-MD-001 in Patients with Abnormal Meibomian Gland Function and Dry Eye Disease (DED)
Azura Ophthalmics
NCT06329791
Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD
Candela Corporation
NCT06064071
Phase 2b Controlled Study
IVIEW Therapeutics
NCT07140380
Burden of Illness and Treatment Assessment of Patients With Dry Eye Disease: A Cross-Sectional Survey of Real-World Patients With Dry Eye Disease in the US
Novartis Pharmaceuticals
NCT06018571
ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)
Novaliq
NCT04523129
Study Evaluating the Safety and Efficacy of AR-15512 (COMET-3)
Aerie Pharmaceuticals
NCT05360966
A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease
Surface Ophthalmics
NCT04734197
A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.
Dompé Farmaceutici S.p.A
NCT06244316
Safety Study of Tivanisiran to Treat Dry Eye
Sylentis, S.A.
NCT05310422
Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome
Lantibio
NCT00599716
The Study Evaluating the Efficacy and Safety of OK-101 in Subjects With Dry Eye Disease
Okyo Pharma
NCT05759208
A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye
Seikagaku Corporation
NCT05411367
Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease
Glaukos Corporation
NCT05119920
Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome
Sylentis, S.A.
NCT04819269
Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease
Bausch & Lomb Incorporated
NCT00667004
Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)
Oyster Point Pharma
NCT03452397
Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease.
Ocular Therapeutix
NCT04362670
A Study of TL-925 as a Treatment for Dry Eye Disease
Telios Pharma
NCT05745064
Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease
Senju Pharmaceutical Co.
NCT04139122
Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease
Dompé Farmaceutici S.p.A
NCT05136170
Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease
Invirsa
NCT05586152
A Study Designed to Evaluate Tear Production
Alcon Research
NCT06544707
A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease
Alcon Research
NCT06544694
Ocular Surface Immune Response in Dry Eye Disease
Tufts Medical Center
NCT02042820
Study Evaluating Techniques for Measuring Tear Production
Aerie Pharmaceuticals
NCT05497479
Evaluation of Ocular Comfort With ISTA Tears vs Systane
Bausch & Lomb Incorporated
NCT01650584
The Visual Effect of an Investigational Artificial Tear in the Tear Layer.
Southern California College of Optometry at Marshall B. Ketchum University
NCT00395759
In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye
BioTissue Holdings
NCT02764814
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 11 |
| Phase 3 | 11 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Dry Eye Disease Trial Landscape
34 indexed Dry Eye Disease studies · 5 recruiting (15%).
Phase mix: 12 late (III/IV) vs 15 early (I/II).
Top sponsor: Bausch & Lomb Incorporated (3 trials), 9 others listed. 34 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Dry Eye Disease?
PlainTrial tracks 34 US clinical trials for Dry Eye Disease, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Dry Eye Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.