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Dry Eye Disease: full-pipeline trial registry
5 of 34 indexed Dry Eye Disease trials are currently recruiting.
Corpus placement: #451 of 28,707 conditions by registered trial count.
34 US clinical trials · 5 currently recruiting · #451 of 28,707 conditions by registered trial count
Dry Eye Disease: 34 US clinical trials tracked, 5 recruiting.
Dry Eye Disease is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Bausch & Lomb Incorporated, running 3 of these trials.
Enrollment posture brief
Registry condition dry-eye-disease
OPEN 5 | RECR 15% | LATE 12 | EARLY 15 | RANK #451 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Coronary Syndrome (15% recruiting · 41 trials)
Dry Eye Disease lists 5 open slots (15% of 34 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Dry Eye Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Dry Eye Disease is recruiting below its size-band peers.
5 of 34 indexed trials (14.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Dry Eye Disease trials is spread across many organizations.
Bausch & Lomb Incorporated accounts for 3 of 34 trials (8.8%). 27 distinct sponsors appear on at least one study for this condition label.
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Typical Dry Eye Disease enrolment sits around 183 participants.
Median target enrolment is 183 among the 34 trials that report a genuine target (sentinel values excluded). 11 of those (32.4%) plan for fewer than 100 participants.
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Dry Eye Disease research is mostly interventional.
31 interventional and 3 observational studies make up this index (91.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
34 total, page 1 of 1
A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease
Bausch & Lomb Incorporated
NCT07128628
A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment
Hoffmann-La Roche
NCT07025811
A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease
AbbVie
NCT07284381
2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD
University of Maryland, Baltimore
NCT04946721
Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).
Instituto Grifols, S.A.
NCT07264517
A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease
Telios Pharma
NCT06225973
A Phase 3 Study to Evaluate AZR-MD-001 in Patients with Abnormal Meibomian Gland Function and Dry Eye Disease (DED)
Azura Ophthalmics
NCT06329791
Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD
Candela Corporation
NCT06064071
Phase 2b Controlled Study
IVIEW Therapeutics
NCT07140380
Burden of Illness and Treatment Assessment of Patients With Dry Eye Disease: A Cross-Sectional Survey of Real-World Patients With Dry Eye Disease in the US
Novartis Pharmaceuticals
NCT06018571
ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)
Novaliq
NCT04523129
Study Evaluating the Safety and Efficacy of AR-15512 (COMET-3)
Aerie Pharmaceuticals
NCT05360966
A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease
Surface Ophthalmics
NCT04734197
A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.
Dompé Farmaceutici S.p.A
NCT06244316
Safety Study of Tivanisiran to Treat Dry Eye
Sylentis, S.A.
NCT05310422
Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome
Lantibio
NCT00599716
The Study Evaluating the Efficacy and Safety of OK-101 in Subjects With Dry Eye Disease
Okyo Pharma
NCT05759208
A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye
Seikagaku Corporation
NCT05411367
Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease
Glaukos Corporation
NCT05119920
Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome
Sylentis, S.A.
NCT04819269
Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease
Bausch & Lomb Incorporated
NCT00667004
Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)
Oyster Point Pharma
NCT03452397
Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease.
Ocular Therapeutix
NCT04362670
A Study of TL-925 as a Treatment for Dry Eye Disease
Telios Pharma
NCT05745064
Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease
Senju Pharmaceutical Co.
NCT04139122
Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease
Dompé Farmaceutici S.p.A
NCT05136170
Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease
Invirsa
NCT05586152
A Study Designed to Evaluate Tear Production
Alcon Research
NCT06544707
A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease
Alcon Research
NCT06544694
Ocular Surface Immune Response in Dry Eye Disease
Tufts Medical Center
NCT02042820
Study Evaluating Techniques for Measuring Tear Production
Aerie Pharmaceuticals
NCT05497479
Evaluation of Ocular Comfort With ISTA Tears vs Systane
Bausch & Lomb Incorporated
NCT01650584
The Visual Effect of an Investigational Artificial Tear in the Tear Layer.
Southern California College of Optometry at Marshall B. Ketchum University
NCT00395759
In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye
BioTissue Holdings
NCT02764814
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 11 |
| Phase 3 | 11 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Dry Eye Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Dry Eye Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Dry Eye Disease page
34 registered trials, 5 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 5 Dry Eye Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Bausch & Lomb Incorporated sponsors the most Dry Eye Disease trials on record, review their full trial history before evaluating a specific study. See Bausch & Lomb Incorporated's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Dry Eye Disease condition card totals 34 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.