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ClinicalTrials.gov 5 recruiting now official registry

Dry Eye Disease clinical trials

5 of 34 indexed Dry Eye Disease trials are currently recruiting.

34 US clinical trials · 5 currently recruiting

Dry Eye Disease is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Bausch & Lomb Incorporated, running 3 of these trials.

The research picture

Dry Eye Disease has 34 registered US clinical trials, 5 of them open to new participants right now, about 15% of the total.

5
recruiting participants now
15%
of trials open to enrollment
12
in Phase 3–4 (later-stage)
3
top sponsor: Bausch & Lomb Incorporated
Phase 14Phase 211Phase 311Phase 41

Active & Recent Trials

34 total, page 1 of 1

RECRUITING Phase 2 423 participants

A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease

Bausch & Lomb Incorporated

NCT07128628

RECRUITING Phase 4 350 participants

A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment

Hoffmann-La Roche

NCT07025811

RECRUITING Phase 3 250 participants

A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease

AbbVie

NCT07284381

RECRUITING 150 participants

2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD

University of Maryland, Baltimore

NCT04946721

RECRUITING Phase 2 100 participants

Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).

Instituto Grifols, S.A.

NCT07264517

ACTIVE NOT RECRUITING Phase 2 880 participants

A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease

Telios Pharma

NCT06225973

ACTIVE NOT RECRUITING Phase 3 500 participants

A Phase 3 Study to Evaluate AZR-MD-001 in Patients with Abnormal Meibomian Gland Function and Dry Eye Disease (DED)

Azura Ophthalmics

NCT06329791

ACTIVE NOT RECRUITING NA 100 participants

Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD

Candela Corporation

NCT06064071

ACTIVE NOT RECRUITING Phase 2 30 participants

Phase 2b Controlled Study

IVIEW Therapeutics

NCT07140380

COMPLETED 946 participants

Burden of Illness and Treatment Assessment of Patients With Dry Eye Disease: A Cross-Sectional Survey of Real-World Patients With Dry Eye Disease in the US

Novartis Pharmaceuticals

NCT06018571

COMPLETED Phase 3 834 participants

ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)

Novaliq

NCT04523129

COMPLETED Phase 3 467 participants

Study Evaluating the Safety and Efficacy of AR-15512 (COMET-3)

Aerie Pharmaceuticals

NCT05360966

COMPLETED Phase 2 349 participants

A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease

Surface Ophthalmics

NCT04734197

COMPLETED Phase 2 317 participants

A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.

Dompé Farmaceutici S.p.A

NCT06244316

COMPLETED Phase 3 301 participants

Safety Study of Tivanisiran to Treat Dry Eye

Sylentis, S.A.

NCT05310422

COMPLETED Phase 3 300 participants

Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome

Lantibio

NCT00599716

COMPLETED Phase 2 240 participants

The Study Evaluating the Efficacy and Safety of OK-101 in Subjects With Dry Eye Disease

Okyo Pharma

NCT05759208

COMPLETED Phase 3 232 participants

A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye

Seikagaku Corporation

NCT05411367

COMPLETED Phase 2 226 participants

Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease

Glaukos Corporation

NCT05119920

COMPLETED Phase 3 203 participants

Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

Sylentis, S.A.

NCT04819269

COMPLETED Phase 2 183 participants

Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease

Bausch & Lomb Incorporated

NCT00667004

COMPLETED Phase 2 165 participants

Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)

Oyster Point Pharma

NCT03452397

COMPLETED Phase 1 153 participants

Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease.

Ocular Therapeutix

NCT04362670

COMPLETED Phase 2 107 participants

A Study of TL-925 as a Treatment for Dry Eye Disease

Telios Pharma

NCT05745064

COMPLETED Phase 1 89 participants

Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease

Senju Pharmaceutical Co.

NCT04139122

COMPLETED Phase 3 85 participants

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease

Dompé Farmaceutici S.p.A

NCT05136170

COMPLETED Phase 1 84 participants

Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease

Invirsa

NCT05586152

COMPLETED Phase 3 81 participants

A Study Designed to Evaluate Tear Production

Alcon Research

NCT06544707

COMPLETED Phase 3 79 participants

A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease

Alcon Research

NCT06544694

COMPLETED 67 participants

Ocular Surface Immune Response in Dry Eye Disease

Tufts Medical Center

NCT02042820

COMPLETED Phase 1 40 participants

Study Evaluating Techniques for Measuring Tear Production

Aerie Pharmaceuticals

NCT05497479

COMPLETED NA 35 participants

Evaluation of Ocular Comfort With ISTA Tears vs Systane

Bausch & Lomb Incorporated

NCT01650584

COMPLETED NA 30 participants

The Visual Effect of an Investigational Artificial Tear in the Tear Layer.

Southern California College of Optometry at Marshall B. Ketchum University

NCT00395759

COMPLETED NA 20 participants

In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye

BioTissue Holdings

NCT02764814

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 11
Phase 3 11
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Dry Eye Disease Trial Landscape

34 indexed Dry Eye Disease studies · 5 recruiting (15%).

Phase mix: 12 late (III/IV) vs 15 early (I/II).

Top sponsor: Bausch & Lomb Incorporated (3 trials), 9 others listed. 34 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Dry Eye Disease?

PlainTrial tracks 34 US clinical trials for Dry Eye Disease, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Dry Eye Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.