Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04966351 · ClinicalTrials.gov registry record · NA
Countermeasures to Circadian Misalignment
A NA study of Metabolic Disease and Insulin Sensitivity, sponsored by Colorado State University.
- Recruiting
- Registry status
- NA
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT04966351: Recruiting NA study of Metabolic Disease and Insulin Sensitivity, sponsored by Colorado State University.
NCT04966351 is a NA study of Metabolic Disease and Insulin Sensitivity that is actively recruiting participants, run by Colorado State University. The registered enrollment target is 32 participants, below the 4,189-participant average among 33 other Metabolic Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04966351, a NA study of Metabolic Disease and Insulin Sensitivity, is actively recruiting participants, sponsored by Colorado State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.
Conditions Studied
Interventions
- BEHAVIORAL Time-restricted feeding
- BEHAVIORAL Circadian Misalignment
Study Locations (1)
Colorado
- Colorado State University - Fort Collins
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2021-07-07 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT04966351 shows while recruiting
NCT04966351 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 4,189-participant average among 33 other Metabolic Disease trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Metabolic Disease appearing as the primary indexed condition, and to 2 interventions - of which Time-restricted feeding is the first listed.
NCT04966351 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT04966351 about?
NCT04966351 is a clinical study titled "Countermeasures to Circadian Misalignment". Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night ...
What is the current status of trial NCT04966351?
This trial is currently recruiting. It is a NA study. The enrollment target is 32 participants. The study started on 2021-07-07. Estimated completion is 2026-06-30.
What conditions does trial NCT04966351 study?
This clinical trial studies the following conditions: Metabolic Disease, Insulin Sensitivity, Circadian Rhythm Sleep Disorder of Shift Work Type.
What interventions are being tested in trial NCT04966351?
The interventions under investigation include: Time-restricted feeding (BEHAVIORAL), Circadian Misalignment (BEHAVIORAL).
Who is sponsoring clinical trial NCT04966351?
This trial is sponsored by Colorado State University, which has 94 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04966351 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metabolic Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04966351's enrollment target sits among peer trials
32 26th of 33 higher than 8 of 33 other Metabolic Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metabolic Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Metabolic Adaptations to Weight Loss With and Without Exercise
RECRUITING · NA
-
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
RECRUITING · NA
-
Exercise Effects on Adipose Tissue Structure and Function
RECRUITING · NA
-
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
RECRUITING · NA
-
HIIT Effects on Cardiometabolic Health
RECRUITING · NA
-
Thermogenic Silencer Regulatory Factors in Humans
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02445781 · 32 participants · Early Phase 1
Differing Levels of Hypoglycemia
- NCT02792270 · 32 participants · NA
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
- NCT03068910 · 32 participants · Early Phase 1
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
- NCT03208868 · 32 participants · NA
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI