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Healthy Volunteers: early-phase trial registry
79 of 284 indexed Healthy Volunteers trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #32 of 28,707 conditions by registered trial count.
284 US clinical trials · 79 currently recruiting · #32 of 28,707 conditions by registered trial count
Healthy Volunteers: 284 US clinical trials tracked, 79 recruiting.
Healthy Volunteers is the subject of 284 registered US clinical trials on ClinicalTrials.gov, 79 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 206 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 16 of these trials.
Enrollment posture brief
Registry condition healthy-volunteers
OPEN 79 | RECR 28% | LATE 6 | EARLY 206 | RANK #32 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Arrhythmias, Cardiac (28% recruiting · 18 trials)
Healthy Volunteers lists 79 open slots (28% of 284 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Healthy Volunteers on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Healthy Volunteers is recruiting below its size-band peers.
79 of 284 indexed trials (27.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Healthy Volunteers trials is spread across many organizations.
Takeda accounts for 16 of 284 trials (5.6%). 144 distinct sponsors appear on at least one study for this condition label.
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Most Healthy Volunteers trials plan to enrol fewer than 100 people.
Median target enrolment is 48 among the 284 trials that report a genuine target (sentinel values excluded). 204 of those (71.8%) plan for fewer than 100 participants.
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Healthy Volunteers research is mostly interventional.
251 interventional and 33 observational studies make up this index (88.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
284 total, page 1 of 6
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
Cytapheresis of Volunteer Donors
National Institute on Aging (NIA)
NCT00104325
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
National Heart, Lung, and Blood Institute (NHLBI)
NCT00071045
Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry
University Hospitals Cleveland Medical Center
NCT05196061
New Heart Imaging Techniques to Evaluate Possible Heart Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01399385
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00114647
Physical and Behavioral Traits of Overweight and Obese Adults
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00428987
Children s Growth and Behavior Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT02390765
Adaptive Optics Retinal Imaging
National Eye Institute (NEI)
NCT02317328
Controls and Healthy Vasculature Initiative
National Heart, Lung, and Blood Institute (NHLBI)
NCT05403151
Imaging Techniques in MRI
National Institutes of Health Clinical Center (CC)
NCT01130545
Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)
NCT00442195
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
National Institutes of Health Clinical Center (CC)
NCT03253705
Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)
National Institute on Aging (NIA)
NCT02339012
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
National Center for Complementary and Integrative Health (NCCIH)
NCT03258580
Studies of Dermatologic Diseases Biospecimen Acquisition Protocol
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT02471352
Sample Collection From Healthy Volunteers for Assay Optimization
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03538600
Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue
National Cancer Institute (NCI)
NCT02379429
Neural and Psychological Mechanisms of Pain Perception
National Center for Complementary and Integrative Health (NCCIH)
NCT02446262
Overlapping Pain Trajectory Study
Children's Hospital Medical Center, Cincinnati
NCT05752396
Classroom Break, Cognition, and Fitness in Elementary School Children
Purdue University
NCT06258941
Neurobiology of Suicide
National Institute of Mental Health (NIMH)
NCT02543983
General Pre-Trial Screening Protocol for Infectious Diseases Research
Beth Israel Deaconess Medical Center
NCT06463704
Ultralow Dose PET Imaging of SSTR2 Radiotracer Uptake
Akiva Mintz
NCT07284589
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Bristol-Myers Squibb
NCT06481306
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT06484075
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Regeneron Pharmaceuticals
NCT05648214
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
National Human Genome Research Institute (NHGRI)
NCT06552754
Explosive Synchronization of Brain Network Activity in Chronic Pain
University of Michigan
NCT04606095
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT03407079
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
Bristol-Myers Squibb
NCT07226817
A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)
Takeda
NCT07229911
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Astellas Pharma Global Development
NCT06544642
Kaempferol Absorption and Pharmacokinetics Evaluation
University of Pittsburgh
NCT07322406
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05545306
Ultrasound to View Abdominal Wall Muscle Layers
Corewell Health South
NCT06955013
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986521 in Healthy Participants.
Bristol-Myers Squibb
NCT07283263
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
National Heart, Lung, and Blood Institute (NHLBI)
NCT06615986
A First-in-human, 3-part Study of MRT-8102 in Healthy Participants and Participants at Cardiovascular Risk With Elevated CRP
Monte Rosa Therapeutics
NCT07119125
4D-MRI for Precision Medicine
University of Virginia
NCT04657042
A First-in-Human Single and Multiple Ascending Dose Study of MT-701
Mirador Therapeutics
NCT07396909
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide
National Institute on Aging (NIA)
NCT06269653
Phase 1 Study of SL-325 in Healthy Volunteers
Shattuck Labs
NCT07158437
Mechanism of Non-invasive Magnetic Stimulation
National Institute on Drug Abuse (NIDA)
NCT03394066
A First-in-Human Single and Multiple Ascending Dose Study of MT-251
Mirador Therapeutics
NCT07423299
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of ABBV-243 in Healthy Adults.
AbbVie
NCT07306754
Flexibility, Alcohol Misuse, and Excitation
University of North Carolina, Chapel Hill
NCT06634771
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
Northwell Health
NCT04755699
A Research Study to Evaluate the Safety of NNC4004-0002 When Given to Participants With Asymptomatic Hyperuricemia
Novo Nordisk A/S
NCT06859073
Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children
Purdue University
NCT06270589
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 198 |
| Phase 2 | 8 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Healthy Volunteers records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Healthy Volunteers trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Healthy Volunteers page
284 registered trials, 79 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 79 Healthy Volunteers trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Takeda sponsors the most Healthy Volunteers trials on record, review their full trial history before evaluating a specific study. See Takeda's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Healthy Volunteers condition card totals 284 registered trials; most-linked intervention Placebo; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.