Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Healthy Volunteers
Open-data reference.
284 US clinical trials · 79 currently recruiting
Active & Recent Trials
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
National Institute of Mental Health (NIMH)
NCT00024635
Cytapheresis of Volunteer Donors
National Institute on Aging (NIA)
NCT00104325
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
National Heart, Lung, and Blood Institute (NHLBI)
NCT00071045
Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry
University Hospitals Cleveland Medical Center
NCT05196061
New Heart Imaging Techniques to Evaluate Possible Heart Disease
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01399385
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00114647
Physical and Behavioral Traits of Overweight and Obese Adults
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00428987
Children s Growth and Behavior Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT02390765
Adaptive Optics Retinal Imaging
National Eye Institute (NEI)
NCT02317328
Controls and Healthy Vasculature Initiative
National Heart, Lung, and Blood Institute (NHLBI)
NCT05403151
Imaging Techniques in MRI
National Institutes of Health Clinical Center (CC)
NCT01130545
Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)
NCT00442195
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
National Institutes of Health Clinical Center (CC)
NCT03253705
Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)
National Institute on Aging (NIA)
NCT02339012
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
National Center for Complementary and Integrative Health (NCCIH)
NCT03258580
Studies of Dermatologic Diseases Biospecimen Acquisition Protocol
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT02471352
Sample Collection From Healthy Volunteers for Assay Optimization
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03538600
Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue
National Cancer Institute (NCI)
NCT02379429
Neural and Psychological Mechanisms of Pain Perception
National Center for Complementary and Integrative Health (NCCIH)
NCT02446262
Overlapping Pain Trajectory Study
Children's Hospital Medical Center, Cincinnati
NCT05752396
Classroom Break, Cognition, and Fitness in Elementary School Children
Purdue University
NCT06258941
Neurobiology of Suicide
National Institute of Mental Health (NIMH)
NCT02543983
General Pre-Trial Screening Protocol for Infectious Diseases Research
Beth Israel Deaconess Medical Center
NCT06463704
Ultralow Dose PET Imaging of SSTR2 Radiotracer Uptake
Akiva Mintz
NCT07284589
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Bristol-Myers Squibb
NCT06481306
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT06484075
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Regeneron Pharmaceuticals
NCT05648214
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
National Human Genome Research Institute (NHGRI)
NCT06552754
Explosive Synchronization of Brain Network Activity in Chronic Pain
University of Michigan
NCT04606095
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT03407079
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
Bristol-Myers Squibb
NCT07226817
A Study of TAK-781 in Healthy Volunteers and in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis (PSC)
Takeda
NCT07229911
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Astellas Pharma Global Development
NCT06544642
Kaempferol Absorption and Pharmacokinetics Evaluation
University of Pittsburgh
NCT07322406
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05545306
Ultrasound to View Abdominal Wall Muscle Layers
Corewell Health South
NCT06955013
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986521 in Healthy Participants.
Bristol-Myers Squibb
NCT07283263
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
National Heart, Lung, and Blood Institute (NHLBI)
NCT06615986
A First-in-human, 3-part Study of MRT-8102 in Healthy Participants and Participants at Cardiovascular Risk With Elevated CRP
Monte Rosa Therapeutics
NCT07119125
4D-MRI for Precision Medicine
University of Virginia
NCT04657042
A First-in-Human Single and Multiple Ascending Dose Study of MT-701
Mirador Therapeutics
NCT07396909
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide
National Institute on Aging (NIA)
NCT06269653
Phase 1 Study of SL-325 in Healthy Volunteers
Shattuck Labs
NCT07158437
Mechanism of Non-invasive Magnetic Stimulation
National Institute on Drug Abuse (NIDA)
NCT03394066
A First-in-Human Single and Multiple Ascending Dose Study of MT-251
Mirador Therapeutics
NCT07423299
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of ABBV-243 in Healthy Adults.
AbbVie
NCT07306754
Flexibility, Alcohol Misuse, and Excitation
University of North Carolina, Chapel Hill
NCT06634771
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
Northwell Health
NCT04755699
A Research Study to Evaluate the Safety of NNC4004-0002 When Given to Participants With Asymptomatic Hyperuricemia
Novo Nordisk A/S
NCT06859073
Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children
Purdue University
NCT06270589
Cognitive Control & the Functional Organization of the Frontal Cortex
Brown University
NCT06436209
ChronoMet: Metabolic and Inflammatory Effects of Eating Timing and Quantity
University of Minnesota
NCT06161337
Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth
University of California, San Diego
NCT06944782
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04799301
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
Karuna Therapeutics
NCT07118215
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
Karuna Therapeutics
NCT07204418
Blood Flow Restriction (BFR) Training on the Ulnar Collateral Ligament (UCL)
The Methodist Hospital Research Institute
NCT06664827
Feasibility Study on Radiofrequency-Based Selective Electrothermolysis to Investigate Its Effects on Human Skin
Johns Hopkins University
NCT05066113
A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants
Genentech
NCT07329972
A Study to Evaluate the Effect of Single Oral Dose of Balinatunfib on Cardiac Repolarization in Healthy Adult Participants.
Sanofi
NCT07272629
A Study to Evaluate the Effect of Itraconazole and Rifampin on the Drug Levels of AR-LDD (BMS-986365) in Healthy Adult Male Participants
Celgene
NCT07242781
Blood Flow Restriction Training on Upper Extremity Grip Strength
Casa Colina Hospital and Centers for Healthcare
NCT06535373
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of ABBV-277 in Healthy Adult Participants
AbbVie
NCT07136103
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MKND-201 in Healthy Volunteers
Mannkind Corporation
NCT06532942
I.V. Selonabant in Healthy Adult Subjects
Anebulo Pharmaceuticals
NCT07211607
Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants
Bristol-Myers Squibb
NCT07223671
A Study to Evaluate the Effect of BMS-986278 on Cardiac Repolarization in Healthy Participants
Bristol-Myers Squibb
NCT07422298
Avocado and Postprandial Responses
University of Vermont Medical Center
NCT06818032
PET Study to Evaluate Brain Receptor Occupancy, Safety and Pharmacokinetics of ITI-1284 in Healthy Subjects
Intra-Cellular Therapies
NCT06299410
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2
Indiana University
NCT07339072
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
Indiana University
NCT07215299
Non-Invasive Respiratory Monitor
Nemours Children's Clinic
NCT02851043
Psilocybin Brain Stimulation and Imaging Pilot Study
Johns Hopkins University
NCT06835699
A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants
Eisai
NCT07308236
Generalization and Specificity of Visual Learning During Sleep
Brown University
NCT07015840
Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors
Radiopharm Theranostics
NCT05799274
KarXT Concentrations in the Breast Milk and Plasma of Lactating Females
Karuna Therapeutics
NCT07257120
Sustained Release Oral Formulation for Treatment of Parkinson's Disease
University of Minnesota
NCT05471609
Effects of Energy Drinks on Cardiovascular Endpoints
University of the Pacific
NCT07212803
The MURDOCK Study Registry and Biorepository Horizon 1.5
Duke University
NCT01708408
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study
National Human Genome Research Institute (NHGRI)
NCT00410241
A Study on the Safety and Immunogenicity of Hexavalent Influenza mRNA Vaccine in Adult Participants 50 Years of Age and Older
Sanofi Pasteur, a Sanofi Company
NCT06744205
Study to Evaluate the Safety and the Immunogenicity of a Second Generation Structurally Designed mRNA Vaccine Candidate Against Pandemic Influenza H5 HA Strain in Healthy Adult Participants Aged 18 Years and Older
Sanofi
NCT06907511
Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA
Sanofi Pasteur, a Sanofi Company
NCT04942210
Analysis of Specimens From Individuals With Pulmonary Fibrosis
National Human Genome Research Institute (NHGRI)
NCT00084305
A Bioequivalence Study of Amlitelimab Delivered by 2 Different Devices in Healthy Adult Participants
Sanofi
NCT07146750
This Study Consists of Two Study Parts Conducted Under a Single IRB. Part I: Short Term ApoE-dependent Cerebral Blood Flow Response to Sirolimus in Cognitively Normal Adults Part II: Short Term ApoE-dependent Cerebral Blood Flow and Lung Perfusion Response to Sirolimus in Cognitively Normal Adults
University of Missouri-Columbia
NCT05386914
Black Raspberry Confection in Preventing Oral Cancer in Healthy Volunteers
Ohio State University Comprehensive Cancer Center
NCT01961869
Investigation of the Gut Microbiome and Statin Response
Sony Tuteja
NCT04098003
Meat and Dietary Pattern Study
USDA Beltsville Human Nutrition Research Center
NCT05589389
Understanding the Effects of Transauricular Vagus Nerve Stimulation on Neural Networks and Autonomic Nervous System
Spaulding Rehabilitation Hospital
NCT05801809
The Effect of Violet Device Dosed Ultra Violet-C Light (UV-C) Exposure on Healthy Hand Skin
University of Michigan
NCT05313555
Neural and Physiological Correlates of Psychedelic Sub-states
Robin Carhart-Harris, PhD, MA
NCT05698511
A Phase 1 Study of a Tablet Form of ABBV-722 Taken With and Without Food in Healthy Adult Participants
AbbVie
NCT07361367
Efficacy and Immunogenicity of Norovirus GI.1/GII.4 Bivalent Virus-like Particle Vaccine in Adults
Takeda
NCT02669121
Study of an Investigational Pentavalent Meningococcal ABCYW Vaccine in Adults and Adolescents
Sanofi Pasteur, a Sanofi Company
NCT06128733
A Study to Investigate Cardiac Troponin Levels After mRNA-1273.712 Vaccine in Participants 12 Through 30 Years of Age
ModernaTX
NCT06634797
Multi-scale Modeling of Sleep Behaviors in Social Networks
Brigham and Women's Hospital
NCT02846077
Long-Term Safety Study of Tafenoquine
60 Degrees Pharmaceuticals
NCT03320174
Study on Two Adjuvanted Dose Levels of Panblok H7+MF59 Compared for Immunogenicity and Safety With an Unadjuvanted Dose of Panblok H7 in Participants 18 Years of Age and Older
Sanofi Pasteur, a Sanofi Company
NCT05608005
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 198 |
| Phase 2 | 8 |
| Phase 4 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Healthy Volunteers Trial Landscape
ClinicalTrials.gov lists 284 US studies indexed under Healthy Volunteers, and 79 of those are currently open to recruitment — roughly 28% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Healthy Volunteers shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 206 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Healthy Volunteers is led by Takeda with 16 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Healthy Volunteers?
PlainTrial tracks 284 US clinical trials for Healthy Volunteers, of which 79 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Healthy Volunteers?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.