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NCT06269653 · ClinicalTrials.gov registry record
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide
A clinical trial of Healthy Volunteers, sponsored by National Institute on Aging (NIA).
- Recruiting
- Registry status
- 75
- Enrollment target
- 1
- Study location
NCT06269653: Recruiting study of Healthy Volunteers, sponsored by National Institute on Aging (NIA).
NCT06269653 is a study of Healthy Volunteers that is actively recruiting participants, run by National Institute on Aging (NIA). The registered enrollment target is 75 participants, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06269653, a study of Healthy Volunteers, is actively recruiting participants, sponsored by National Institute on Aging (NIA).
- RECRUITING
- Registry status
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Proteins are essential to the health and structure of the cells that make up body tissues. Most proteins become damaged over time and are replaced with new ones. This process is called "protein turnover." Stress, disease, and aging can affect this process. Researchers want to better understand how aging affects protein turnover. Objective: To measure rates of protein turnover in healthy adults. Eligibility: Healthy people aged 20 years and older with a body mass index between 20 and 30. Design: Participants will have 6 study visits over 4 to 6 weeks. They will fast 12 hours before each visit. Participants will be screened. They will have a physical exam, with blood and urine tests and tests of their heart function. They will lie down while blood pressure cuffs are used on their arms and legs. Participants will be given bottles of heavy water to drink at home on a schedule for 21 days. Each bottle holds about 3.5 tablespoons. Heavy water is odorless, colorless, and tasteless, like normal drinking water. It is safe to drink and has been used in research for many years. Participants will have tests during study visits, including: Imaging scans of a leg. Exercise on a treadmill. Biopsies of muscle, skin, and fat: Small samples of tissue will be cut from the calf and abdomen. Resting metabolic rate: Participants will lie still and breathe into a mask for 20 minutes. Knee/grip strength: Participants will do strength tests with their legs. They will squeeze a device with their hands. D3-Creatine: Participants will take 1 pill of D3-Creatine, which occurs naturally in muscle.
Primary Outcome
No data is available on proteins half-life that compare different tissues in humans; and this information would be important to interpret proteomic data. Comprehensively profile the turnover rates and half-lives of different proteins in human skeletal muscle.
Conditions Studied
Study Locations (1)
Maryland
- National Institute of Aging, Clinical Research Unit - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2024-06-26 |
| Est. Completion | 2027-03-01 |
What NCT06269653 shows while recruiting
NCT06269653 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (84% lower).
The record links to 1 condition, with Healthy Volunteers appearing as the primary indexed condition, and to 0 interventions.
NCT06269653 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT06269653 about?
NCT06269653 is a clinical study titled "Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide". Background: Proteins are essential to the health and structure of the cells that make up body tissues. Most proteins become damaged over time and are replaced with new ones. This process is called "protein turnover." Stress, disease, and aging can affect this process. Researchers want to better und...
What is the current status of trial NCT06269653?
This trial is currently recruiting. The enrollment target is 75 participants. The study started on 2024-06-26. Estimated completion is 2027-03-01.
What conditions does trial NCT06269653 study?
This clinical trial studies the following conditions: Healthy Volunteers.
Who is sponsoring clinical trial NCT06269653?
This trial is sponsored by National Institute on Aging (NIA), which has 131 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06269653 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06269653's enrollment target sits among peer trials
75 92nd of 283 higher than 192 of 283 other Healthy Volunteers trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Volunteers trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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