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Healthy Volunteers: early-phase trial registry
79 of 284 indexed Healthy Volunteers trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #32 of 28,707 conditions by registered trial count.
284 US clinical trials · 79 currently recruiting · #32 of 28,707 conditions by registered trial count
Healthy Volunteers: 284 US clinical trials tracked, 79 recruiting.
Healthy Volunteers is the subject of 284 registered US clinical trials on ClinicalTrials.gov, 79 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 206 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 16 of these trials.
Enrollment posture brief
Registry condition healthy-volunteers
OPEN 79 | RECR 28% | LATE 6 | EARLY 206 | RANK #32 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Arrhythmias, Cardiac (28% recruiting · 18 trials)
Healthy Volunteers lists 79 open slots (28% of 284 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Healthy Volunteers on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Healthy Volunteers is recruiting below its size-band peers.
79 of 284 indexed trials (27.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Healthy Volunteers trials is spread across many organizations.
Takeda accounts for 16 of 284 trials (5.6%). 144 distinct sponsors appear on at least one study for this condition label.
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Most Healthy Volunteers trials plan to enrol fewer than 100 people.
Median target enrolment is 48 among the 284 trials that report a genuine target (sentinel values excluded). 204 of those (71.8%) plan for fewer than 100 participants.
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Healthy Volunteers research is mostly interventional.
251 interventional and 33 observational studies make up this index (88.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
284 total, page 2 of 6
Cognitive Control & the Functional Organization of the Frontal Cortex
Brown University
NCT06436209
ChronoMet: Metabolic and Inflammatory Effects of Eating Timing and Quantity
University of Minnesota
NCT06161337
Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth
University of California, San Diego
NCT06944782
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04799301
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
Karuna Therapeutics
NCT07118215
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants
Karuna Therapeutics
NCT07204418
Blood Flow Restriction (BFR) Training on the Ulnar Collateral Ligament (UCL)
The Methodist Hospital Research Institute
NCT06664827
Feasibility Study on Radiofrequency-Based Selective Electrothermolysis to Investigate Its Effects on Human Skin
Johns Hopkins University
NCT05066113
A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants
Genentech
NCT07329972
A Study to Evaluate the Effect of Single Oral Dose of Balinatunfib on Cardiac Repolarization in Healthy Adult Participants.
Sanofi
NCT07272629
A Study to Evaluate the Effect of Itraconazole and Rifampin on the Drug Levels of AR-LDD (BMS-986365) in Healthy Adult Male Participants
Celgene
NCT07242781
Blood Flow Restriction Training on Upper Extremity Grip Strength
Casa Colina Hospital and Centers for Healthcare
NCT06535373
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of ABBV-277 in Healthy Adult Participants
AbbVie
NCT07136103
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MKND-201 in Healthy Volunteers
Mannkind Corporation
NCT06532942
I.V. Selonabant in Healthy Adult Subjects
Anebulo Pharmaceuticals
NCT07211607
Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants
Bristol-Myers Squibb
NCT07223671
A Study to Evaluate the Effect of BMS-986278 on Cardiac Repolarization in Healthy Participants
Bristol-Myers Squibb
NCT07422298
Avocado and Postprandial Responses
University of Vermont Medical Center
NCT06818032
PET Study to Evaluate Brain Receptor Occupancy, Safety and Pharmacokinetics of ITI-1284 in Healthy Subjects
Intra-Cellular Therapies
NCT06299410
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2
Indiana University
NCT07339072
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
Indiana University
NCT07215299
Non-Invasive Respiratory Monitor
Nemours Children's Clinic
NCT02851043
Psilocybin Brain Stimulation and Imaging Pilot Study
Johns Hopkins University
NCT06835699
A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants
Eisai
NCT07308236
Generalization and Specificity of Visual Learning During Sleep
Brown University
NCT07015840
Safety of RAD301 in Healthy Human Volunteers and Patients With Pancreatic Cancer or Other Solid Tumors
Radiopharm Theranostics
NCT05799274
KarXT Concentrations in the Breast Milk and Plasma of Lactating Females
Karuna Therapeutics
NCT07257120
Sustained Release Oral Formulation for Treatment of Parkinson's Disease
University of Minnesota
NCT05471609
Effects of Energy Drinks on Cardiovascular Endpoints
University of the Pacific
NCT07212803
The MURDOCK Study Registry and Biorepository Horizon 1.5
Duke University
NCT01708408
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study
National Human Genome Research Institute (NHGRI)
NCT00410241
A Study on the Safety and Immunogenicity of Hexavalent Influenza mRNA Vaccine in Adult Participants 50 Years of Age and Older
Sanofi Pasteur, a Sanofi Company
NCT06744205
Study to Evaluate the Safety and the Immunogenicity of a Second Generation Structurally Designed mRNA Vaccine Candidate Against Pandemic Influenza H5 HA Strain in Healthy Adult Participants Aged 18 Years and Older
Sanofi
NCT06907511
Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA
Sanofi Pasteur, a Sanofi Company
NCT04942210
Analysis of Specimens From Individuals With Pulmonary Fibrosis
National Human Genome Research Institute (NHGRI)
NCT00084305
A Bioequivalence Study of Amlitelimab Delivered by 2 Different Devices in Healthy Adult Participants
Sanofi
NCT07146750
This Study Consists of Two Study Parts Conducted Under a Single IRB. Part I: Short Term ApoE-dependent Cerebral Blood Flow Response to Sirolimus in Cognitively Normal Adults Part II: Short Term ApoE-dependent Cerebral Blood Flow and Lung Perfusion Response to Sirolimus in Cognitively Normal Adults
University of Missouri-Columbia
NCT05386914
Black Raspberry Confection in Preventing Oral Cancer in Healthy Volunteers
Ohio State University Comprehensive Cancer Center
NCT01961869
Investigation of the Gut Microbiome and Statin Response
Sony Tuteja
NCT04098003
Meat and Dietary Pattern Study
USDA Beltsville Human Nutrition Research Center
NCT05589389
Understanding the Effects of Transauricular Vagus Nerve Stimulation on Neural Networks and Autonomic Nervous System
Spaulding Rehabilitation Hospital
NCT05801809
The Effect of Violet Device Dosed Ultra Violet-C Light (UV-C) Exposure on Healthy Hand Skin
University of Michigan
NCT05313555
Neural and Physiological Correlates of Psychedelic Sub-states
Robin Carhart-Harris, PhD, MA
NCT05698511
A Phase 1 Study of a Tablet Form of ABBV-722 Taken With and Without Food in Healthy Adult Participants
AbbVie
NCT07361367
Efficacy and Immunogenicity of Norovirus GI.1/GII.4 Bivalent Virus-like Particle Vaccine in Adults
Takeda
NCT02669121
Study of an Investigational Pentavalent Meningococcal ABCYW Vaccine in Adults and Adolescents
Sanofi Pasteur, a Sanofi Company
NCT06128733
A Study to Investigate Cardiac Troponin Levels After mRNA-1273.712 Vaccine in Participants 12 Through 30 Years of Age
ModernaTX
NCT06634797
Multi-scale Modeling of Sleep Behaviors in Social Networks
Brigham and Women's Hospital
NCT02846077
Long-Term Safety Study of Tafenoquine
60 Degrees Pharmaceuticals
NCT03320174
Study on Two Adjuvanted Dose Levels of Panblok H7+MF59 Compared for Immunogenicity and Safety With an Unadjuvanted Dose of Panblok H7 in Participants 18 Years of Age and Older
Sanofi Pasteur, a Sanofi Company
NCT05608005
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 198 |
| Phase 2 | 8 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Healthy Volunteers records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Healthy Volunteers trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Healthy Volunteers page
284 registered trials, 79 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 79 Healthy Volunteers trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Takeda sponsors the most Healthy Volunteers trials on record, review their full trial history before evaluating a specific study. See Takeda's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Healthy Volunteers condition card totals 284 registered trials; most-linked intervention Placebo; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.