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NCT07119125 · ClinicalTrials.gov registry record · Phase 1
A First-in-human, 3-part Study of MRT-8102 in Healthy Participants and Participants at Cardiovascular Risk With Elevated CRP
A Phase 1 study of Healthy Volunteers and Elevated CRP, sponsored by Monte Rosa Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 100
- Enrollment target
- 4
- Study locations
NCT07119125 is a Phase 1 study of Healthy Volunteers and Elevated CRP that is actively recruiting participants, run by Monte Rosa Therapeutics. The registered enrollment target is 100 participants, below the 481-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (79% lower). The trial reports 4 study locations across 4 states.
The verdict
NCT07119125, a Phase 1 study of Healthy Volunteers and Elevated CRP, is actively recruiting participants, sponsored by Monte Rosa Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 100 participants
- Enrollment target
- 4
- Study locations
Study Summary
The principal aim of this study is to obtain safety and tolerability data when MRT-8102 is administered orally as single and multiple doses to healthy participants and participants at cardiovascular risk with elevated CRP. This information, together with the pharmacokinetic (PK) data, will help establish the dose and dosing regimen suitable for future studies. The study drug, MRT-8102, is experimental. This is the first study in which MRT-8102 will be given to humans. Part 1: Healthy participants will receive a single oral dose of MRT-8102 or placebo on Day 1 Part 2: Healthy participants will receive multiple oral doses of MRT-8102 or placebo for 7 consecutive days Part 3: Participants at cardiovascular risk with elevated CRP will receive multiple oral doses of MRT-8102 or placebo for 28 consecutive days
Conditions Studied
Interventions
- DRUG Placebo
- DRUG MRT-8102
Study Locations (4)
Florida
- Clinical Pharmacology of Miami, LLC - Miami
Kansas
- ICON Clinical Research - Lenexa
Missouri
- QPS - Springfield
Texas
- Endeavor Clinical Trials - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-06-27 |
| Est. Completion | 2026-03 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07119125
The ClinicalTrials.gov registry entry for NCT07119125 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 481-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (79% lower). The listed sponsor is Monte Rosa Therapeutics, which has 3 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Healthy Volunteers appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07119125 reports 4 study locations spanning 4 distinct geographic areas - top geographies include Florida, Kansas, Missouri.
Frequently Asked Questions
What is clinical trial NCT07119125 about?
NCT07119125 is a clinical study titled "A First-in-human, 3-part Study of MRT-8102 in Healthy Participants and Participants at Cardiovascular Risk With Elevated CRP". The principal aim of this study is to obtain safety and tolerability data when MRT-8102 is administered orally as single and multiple doses to healthy participants and participants at cardiovascular risk with elevated CRP. This information, together with the pharmacokinetic (PK) data, will help esta...
What is the current status of trial NCT07119125?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2025-06-27. Estimated completion is 2026-03.
What conditions does trial NCT07119125 study?
This clinical trial studies the following conditions: Healthy Volunteers, Elevated CRP.
What interventions are being tested in trial NCT07119125?
The interventions under investigation include: Placebo (DRUG), MRT-8102 (DRUG).
Who is sponsoring clinical trial NCT07119125?
This trial is sponsored by Monte Rosa Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07119125 being conducted?
This trial has 4 study locations across Florida, Kansas, Missouri, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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