Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06634771 · ClinicalTrials.gov registry record · NA
Flexibility, Alcohol Misuse, and Excitation
A NA study of Healthy Volunteers and Behavioral Flexibility, sponsored by University of North Carolina, Chapel Hill.
- Recruiting
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT06634771: Recruiting NA study of Healthy Volunteers and Behavioral Flexibility, sponsored by University of North Carolina, Chapel Hill.
NCT06634771 is a NA study of Healthy Volunteers and Behavioral Flexibility that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 66 participants, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06634771, a NA study of Healthy Volunteers and Behavioral Flexibility, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.
- RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to learn whether a single non-invasive brain stimulation alpha-transcranial alternating current stimulation (alpha-tACS) session changes measures of excitability in the prefrontal cortex. It will also learn whether these changes predict differences in habitual action selection in a laboratory task and whether the effects depend on alcohol use history. The main questions it aims to answer are: Does alpha-tACS reduce habitual action selection by reducing excitability in the prefrontal cortex? Is alpha-tACS most effective in reducing habitual action selection in hazardous drinkers who engaged in binge-drinking during adolescence? Researchers will compare alpha-tACS to sham stimulation to see if alpha-tACS changes habitual action selection by changing prefrontal excitability. Participants will: Visit the lab for behavioral training Visit the imaging center for an MRI session Visit the lab to receive alpha-tACS or sham stimulation during behavioral testing and undergo EEG recordings before and after stimulation Visit the imaging center for a repeat MRI session Provide a small sample of blood from a finger-prick in the first and last visits.
Primary Outcome
In the HABIT task participants are trained to associate abstract images on the computer screen with specific responses (button presses). They initially learn two stimulus-response pairings and then practice these two pairings at the beginning of each session; these are referred to as the familiar (FAM) sets. At sessions 2 and 3 they also learn two new stimulus-response pairings, which are referred to as the novel (NOV) sets and which they do not encounter at later sessions. During sessions 2 and
Conditions Studied
Interventions
- DEVICE 10 Hz transcranial alternating current stimulation (tACS)
- DEVICE sham transcranial alternating current stimulation (tACS)
Study Locations (1)
North Carolina
- University of North Carolina, Chapel Hill - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2024-07-18 |
| Est. Completion | 2027-11-30 |
| Phase | NA |
What NCT06634771 shows while recruiting
NCT06634771 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 482-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (86% lower).
The record links to 3 conditions, with Healthy Volunteers appearing as the primary indexed condition, and to 2 interventions - of which 10 Hz transcranial alternating current stimulation (tACS) is the first listed.
NCT06634771 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT06634771 about?
NCT06634771 is a clinical study titled "Flexibility, Alcohol Misuse, and Excitation". The goal of this study is to learn whether a single non-invasive brain stimulation alpha-transcranial alternating current stimulation (alpha-tACS) session changes measures of excitability in the prefrontal cortex. It will also learn whether these changes predict differences in habitual action select...
What is the current status of trial NCT06634771?
This trial is currently recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2024-07-18. Estimated completion is 2027-11-30.
What conditions does trial NCT06634771 study?
This clinical trial studies the following conditions: Healthy Volunteers, Behavioral Flexibility, High Risk Alcohol Use.
What interventions are being tested in trial NCT06634771?
The interventions under investigation include: 10 Hz transcranial alternating current stimulation (tACS) (DEVICE), sham transcranial alternating current stimulation (tACS) (DEVICE).
Who is sponsoring clinical trial NCT06634771?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06634771 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy Volunteers
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06634771's enrollment target sits among peer trials
66 101st of 283 higher than 181 of 283 other Healthy Volunteers trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Volunteers trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children
RECRUITING · NA
-
New Heart Imaging Techniques to Evaluate Possible Heart Disease
RECRUITING · NA
-
Blood Flow Restriction Training on Upper Extremity Grip Strength
RECRUITING · NA
-
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
RECRUITING · NA
-
Avocado and Postprandial Responses
RECRUITING · NA
-
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02584244 · 66 participants · Phase 1
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
- NCT03067051 · 66 participants · Phase 1
Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
- NCT03754725 · 66 participants · Phase 1
Ferritin and Iron Burden in SAH sIRB
- NCT03875378 · 66 participants · Phase 2
Transdermal Estrogen in Women With Anorexia Nervosa
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI