Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Leukemia

Open-data reference.

273 US clinical trials · 51 currently recruiting

Active & Recent Trials

RECRUITING 15,000 participants

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

UNC Lineberger Comprehensive Cancer Center

NCT01137643

RECRUITING 5,000 participants

Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies

Children's Oncology Group

NCT00736749

RECRUITING 3,000 participants

Registry of Older Patients With Cancer

UNC Lineberger Comprehensive Cancer Center

NCT01137825

RECRUITING NA 700 participants

HEME Home Transfusion Program

Dana-Farber Cancer Institute

NCT06487247

RECRUITING Phase 3 700 participants

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

Daiichi Sankyo

NCT06578247

RECRUITING 500 participants

Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

Memorial Sloan Kettering Cancer Center

NCT00582621

RECRUITING NA 500 participants

DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics

UNC Lineberger Comprehensive Cancer Center

NCT06296368

RECRUITING NA 400 participants

Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care

University of Miami

NCT05745285

RECRUITING NA 356 participants

Mosaic Trial for Stem Cell Transplant Recipients

Northwestern University

NCT06960993

RECRUITING 300 participants

Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow Specimens From Children And Young Adults With Hematologic Malignancy

Dana-Farber Cancer Institute

NCT04968834

RECRUITING 300 participants

Pre-malignant States to Hematologic Malignancies in Firefighters

Wake Forest University Health Sciences

NCT06870760

RECRUITING Phase 1 171 participants

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Kura Oncology

NCT06001788

RECRUITING Phase 1 170 participants

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

BlossomHill Therapeutics

NCT06501196

RECRUITING Phase 2 160 participants

Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

M.D. Anderson Cancer Center

NCT01515527

RECRUITING NA 140 participants

Effects of Using a Storybook, to Explain Leukemia to Children Versus the Standard Child Life Intervention, on Parental Stress.

Children's Hospital Los Angeles

NCT06360718

RECRUITING Phase 2 130 participants

Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission

Daiichi Sankyo

NCT06824168

RECRUITING Phase 2 124 participants

Dose-Expansion Study of Low Dose Post-Transplant Cyclophosphamide/Tacrolimus/Ruxolitinib for Graft-versus-Host Disease (GVHD) Prophylaxis in Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation

Hannah Choe, MD

NCT07249346

RECRUITING Phase 1 104 participants

CApivasertib, Venetoclax And Low-intensity chemotheRapY for Adults With ALL/LBL

University of Chicago

NCT07294677

RECRUITING Early Phase 1 100 participants

Exercise as an Immune Adjuvant for Allogeneic Cell Therapies

University of Arizona

NCT06643221

RECRUITING Early Phase 1 100 participants

Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC

Children's Hospital of Philadelphia

NCT02356653

RECRUITING Phase 1 100 participants

Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

Children's Hospital of Philadelphia

NCT06839456

RECRUITING 100 participants

Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies

M.D. Anderson Cancer Center

NCT05011045

RECRUITING NA 90 participants

Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy

Massachusetts General Hospital

NCT05646576

RECRUITING 88 participants

Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

National Cancer Institute (NCI)

NCT06856226

RECRUITING NA 88 participants

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant

University of Nebraska

NCT04898790

RECRUITING Phase 1 82 participants

Venetoclax and Chemotherapy as Frontline Therapy in Older Patients and Patients With Relapsed/Refractory ALL

Dana-Farber Cancer Institute

NCT03319901

RECRUITING NA 75 participants

Tools for Reducing Inequity in Acute Leukemia (TRIAL): Beta Testing

Dana-Farber Cancer Institute

NCT06907797

RECRUITING NA 70 participants

Spiritual Care Intervention in Adult Patients Diagnosed With Acute Leukemia

University of Chicago

NCT07405424

RECRUITING Phase 1 64 participants

Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL)

Jennifer R. Brown, MD, PhD

NCT06644183

RECRUITING NA 60 participants

A Music Therapy Study for Blood Cancer Survivors With Cognitive Difficulties

Memorial Sloan Kettering Cancer Center

NCT07052916

RECRUITING Phase 2 60 participants

Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)

M.D. Anderson Cancer Center

NCT05536349

RECRUITING 60 participants

Cognitive Aftereffects of Neurotoxicity in Children and Young Adults With Relapsed/Refractory Hematologic Malignancies Who Receive CAR T-cell Therapy

National Cancer Institute (NCI)

NCT05237986

RECRUITING Phase 1 52 participants

A Study of Revumenib and Mezigdomide in People With Leukemia

Memorial Sloan Kettering Cancer Center

NCT07356154

RECRUITING NA 40 participants

Driving Inclusivity, Validity, and Equity in Research Through Strategic Engagement (DIVERSE)

Dana-Farber Cancer Institute

NCT06469307

RECRUITING Phase 1 40 participants

Mosunetuzumab for CLL MRD Clearance

Inhye Ahn

NCT07052695

RECRUITING 40 participants

Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors

M.D. Anderson Cancer Center

NCT01608152

RECRUITING Phase 2 40 participants

A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated With Upregulation of HOX Genes

M.D. Anderson Cancer Center

NCT06229912

RECRUITING NA 40 participants

MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing

Medical College of Wisconsin

NCT05794880

RECRUITING Phase 1 31 participants

A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

Jacqueline Garcia, MD

NCT07148180

RECRUITING 30 participants

Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution

Children's Hospital Medical Center, Cincinnati

NCT06131801

RECRUITING NA 30 participants

I Can Move With Purpose Now! A Pilot Lifestyle Intervention Study in Myeloproliferative Neoplasm Patients

Massachusetts General Hospital

NCT05842603

RECRUITING Phase 1 30 participants

Mitoxantrone for Venetoclax Resistant Acute Myeloid Leukemia

University of Colorado, Denver

NCT06429449

RECRUITING Phase 1 29 participants

A Prospective Trial of Dalbavancin-Based Prophylaxis in Children and Adolescents With High-Risk Leukemia

St. Jude Children's Research Hospital

NCT06810583

RECRUITING Phase 2 27 participants

Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT05645718

RECRUITING Phase 1 22 participants

Revumenib in Combination With 7+3 + Midostaurin in AML

Richard Stone, MD

NCT06313437

RECRUITING Phase 1 21 participants

Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia

Children's Hospital Medical Center, Cincinnati

NCT03826992

RECRUITING 20 participants

Improving Communication and Building a Stronger Medical Home Among Spanish-speaking Families

University of Colorado, Denver

NCT05425992

RECRUITING Phase 1 20 participants

Autologous CD22 CAR T Cells Following Commercial CD19 CAR T Cells in B Cell Malignancies

Stanford University

NCT06408194

RECRUITING Phase 1 15 participants

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT06138587

RECRUITING Phase 1 10 participants

CIML NK Cells With Venetoclax for AML

Dana-Farber Cancer Institute

NCT06152809

RECRUITING

3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer

Barbara Ann Karmanos Cancer Institute

NCT00935090

ACTIVE NOT RECRUITING 57,816 participants

Enrollment on the Childhood Cancer Research Network (CCRN) of the Children's Oncology Group

Children's Oncology Group

NCT01117168

ACTIVE NOT RECRUITING 992 participants

Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers

Memorial Sloan Kettering Cancer Center

NCT00579163

ACTIVE NOT RECRUITING 840 participants

Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia

Alliance for Clinical Trials in Oncology

NCT00003861

ACTIVE NOT RECRUITING 600 participants

Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia

Alliance for Clinical Trials in Oncology

NCT00898456

ACTIVE NOT RECRUITING NA 511 participants

Selection of Allogeneic Hematopoietic Cell Donors Based on KIR and HLA Genotypes

Memorial Sloan Kettering Cancer Center

NCT02450708

ACTIVE NOT RECRUITING Phase 3 173 participants

Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

Children's Oncology Group

NCT03057054

ACTIVE NOT RECRUITING Phase 2 140 participants

Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies

Children's Hospital of Philadelphia

NCT02323867

ACTIVE NOT RECRUITING Phase 2 120 participants

Combination of Lenalidomide and Rituximab in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL-SLL)

M.D. Anderson Cancer Center

NCT01446133

ACTIVE NOT RECRUITING Phase 2 99 participants

Nivolumab and/or Ipilimumab With or Without Azacitidine in Treating Patients With Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT02530463

ACTIVE NOT RECRUITING Phase 1 93 participants

Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19

Memorial Sloan Kettering Cancer Center

NCT01044069

ACTIVE NOT RECRUITING Phase 2 86 participants

PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

National Heart, Lung, and Blood Institute (NHLBI)

NCT01500733

ACTIVE NOT RECRUITING Phase 2 85 participants

A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia

Dana-Farber Cancer Institute

NCT02251548

ACTIVE NOT RECRUITING Phase 2 82 participants

Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

Memorial Sloan Kettering Cancer Center

NCT01746849

ACTIVE NOT RECRUITING Phase 1 78 participants

A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia

Seattle Children's Hospital

NCT03330691

ACTIVE NOT RECRUITING Phase 1 75 participants

Helical Tomotherapy, Fludarabine Phosphate, and Melphalan Followed By Allo-HSCT in Hematological Malignancies

City of Hope Medical Center

NCT00544466

ACTIVE NOT RECRUITING Phase 2 63 participants

SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer

GeoVax

NCT04977024

ACTIVE NOT RECRUITING Phase 1 54 participants

Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL

Baylor College of Medicine

NCT00881920

ACTIVE NOT RECRUITING Phase 1 52 participants

AZD6738 for Patients With Progressive MDS or CMML

Massachusetts General Hospital

NCT03770429

ACTIVE NOT RECRUITING Phase 1 51 participants

Intensity-Modulated Radiation Therapy, Etoposide, and Cyclophosphamide Followed By Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia

City of Hope Medical Center

NCT00576979

ACTIVE NOT RECRUITING NA 50 participants

Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors

St. Jude Children's Research Hospital

NCT06053268

ACTIVE NOT RECRUITING Phase 1 50 participants

Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19

Memorial Sloan Kettering Cancer Center

NCT00466531

ACTIVE NOT RECRUITING Phase 1 42 participants

A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD22 for Relapsed/Refractory Leukemia or Lymphoma

Seattle Children's Hospital

NCT04571138

ACTIVE NOT RECRUITING Phase 1 40 participants

A Phase 1, Open-Label, Sequential Cross-over, Bioavailability/Bioequivalence Study to Compare the Pharmacokinetics of Oral Cladribine With the Reference Listed Drug, Intravenous Cladribine

M.D. Anderson Cancer Center

NCT06021600

ACTIVE NOT RECRUITING Phase 2 39 participants

A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia

Memorial Sloan Kettering Cancer Center

NCT01920737

ACTIVE NOT RECRUITING NA 35 participants

Integrated Actionable Aging Assessment for Cancer Patients Pilot

University of Colorado, Denver

NCT05871008

ACTIVE NOT RECRUITING Phase 2 30 participants

A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia

Memorial Sloan Kettering Cancer Center

NCT03410875

ACTIVE NOT RECRUITING Phase 2 29 participants

Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion

H. Lee Moffitt Cancer Center and Research Institute

NCT03722407

ACTIVE NOT RECRUITING Phase 2 26 participants

A Phase II Study of the Combination of Ponatinib With Mini-hyper CVD Chemotherapy and Venetoclax in Patients With Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT05268003

ACTIVE NOT RECRUITING Phase 2 24 participants

A Study of CPI-613 for Patients With Relapsed or Refractory Burkitt Lymphoma/Leukemia or High-Grade B-Cell Lymphoma With High-Risk Translocations

Memorial Sloan Kettering Cancer Center

NCT03793140

ACTIVE NOT RECRUITING NA 20 participants

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05763563

ACTIVE NOT RECRUITING Phase 1 16 participants

CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma

Seattle Children's Hospital

NCT03684889

ACTIVE NOT RECRUITING Phase 1 16 participants

A Study of GDX012 in Adults With Relapsed or Refractory Acute Myeloid Leukemia

Takeda

NCT05886491

ACTIVE NOT RECRUITING Phase 1 14 participants

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

Memorial Sloan Kettering Cancer Center

NCT02932280

ACTIVE NOT RECRUITING Phase 1 13 participants

Talazoparib for Cohesin-Mutated AML and MDS With Excess Blasts

Dana-Farber Cancer Institute

NCT03974217

ACTIVE NOT RECRUITING NA 12 participants

Pilot of a Trial Enrollment Diversity Dashboard

Dana-Farber Cancer Institute

NCT06795139

ACTIVE NOT RECRUITING Phase 1 10 participants

Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant

Bellicum Pharmaceuticals

NCT02477878

ACTIVE NOT RECRUITING Phase 1 4 participants

A Phase 1 Study of CD22-CAR TCell Immunotherapy for CD22+ Leukemia and Lymphoma

Seattle Children's Hospital

NCT03244306

COMPLETED Phase 3 3,054 participants

Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia

Children's Oncology Group

NCT00005945

COMPLETED Phase 3 2,078 participants

Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia

Children's Oncology Group

NCT00002812

COMPLETED 1,769 participants

A Study to Evaluate Available Treatment Information of Ponatinib, Bosutinib, Imatinib, Dasatinib and Nilotinib in Adults With Chronic Myeloid Leukemia

Takeda

NCT05743465

COMPLETED 1,340 participants

Genome Expression in Lymphoma, Leukemia and Multiple Myeloma

National Cancer Institute (NCI)

NCT00339963

COMPLETED 1,294 participants

S9910, Collecting and Storing Blood and Bone Marrow Samples From Patients With Hematologic Cancer

SWOG Cancer Research Network

NCT00919425

COMPLETED Phase 3 744 participants

Interferon-alfa With or Without Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia

Eastern Cooperative Oncology Group

NCT00002868

COMPLETED 629 participants

Case-Control Study of Pesticides and Childhood Leukemia

National Cancer Institute (NCI)

NCT00342888

COMPLETED Phase 3 502 participants

Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer

Mayo Clinic

NCT00661999

COMPLETED 459 participants

Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant

City of Hope Medical Center

NCT00964821

COMPLETED 451 participants

Relationship Between Natural Killer Cells' Ability to Kill Leukemia Cells and the Outcome of Patients With Acute Myeloid Leukemia Previously Treated With Interleukin-2

Alliance for Clinical Trials in Oncology

NCT00896701

COMPLETED Phase 1 410 participants

Combination Chemotherapy Plus PSC 833 Followed by Interleukin-2 in Treating Patients With Acute Myelogenous Leukemia

National Cancer Institute (NCI)

NCT00002925

COMPLETED Phase 2 361 participants

Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer

Roswell Park Cancer Institute

NCT00003816

Phase Distribution

PhaseTrial count
Early Phase 1 97
Phase 2 95
Phase 3 18
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Leukemia Trial Landscape

ClinicalTrials.gov lists 273 US studies indexed under Leukemia, and 51 of those are currently open to recruitment — roughly 19% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Leukemia shows 19 late-stage studies (Phase 3 and Phase 4 combined) alongside 192 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Leukemia is led by M.D. Anderson Cancer Center with 37 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Leukemia?

PlainTrial tracks 273 US clinical trials for Leukemia, of which 51 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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