Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 4 of 14
Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest
Massachusetts General Hospital
NCT07143357
CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth
Vanderbilt University
NCT05456035
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
Baylor College of Medicine
NCT05489042
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
University of Minnesota
NCT05652153
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
University of Michigan
NCT06574035
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Boston Medical Center
NCT06812247
Study on Allopregnanolone and Depression in Women Across the Menopause Transition
Brigham and Women's Hospital
NCT06238700
Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners
University of Michigan
NCT06324383
Training Reward Responsiveness Through Virtual Reality
University of California, Los Angeles
NCT07219875
Potential Benefits of Parent Child Interaction Therapy (PCIT)
University of Florida
NCT06827951
Probiotic Administration for Adolescent Depression
University of California, San Francisco
NCT06898788
Mood and Thought Process Study
Butler Hospital
NCT05585775
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
Brigham and Women's Hospital
NCT05555875
Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
Laureate Institute for Brain Research
NCT06263660
Understanding the Role of Doulas in Supporting People With PMADs
University of Montana
NCT05763537
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
University of Illinois at Chicago
NCT06261463
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
University of California, San Diego
NCT05682677
Dopaminergic Therapy for Anhedonia - 2
Emory University
NCT06075771
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
NCT03973268
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
Washington University School of Medicine
NCT06867549
A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
Weill Medical College of Cornell University
NCT05507138
Mindfulness Engaged Neurostimulation for Depression
University of California, San Diego
NCT06399406
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
National Institute of Mental Health (NIMH)
NCT04582916
Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities
University of Michigan
NCT06721559
Impact of Depression on Thermoregulation
Penn State University
NCT06805851
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
Deepak C. D'Souza
NCT06671977
Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
Henry Ford Health System
NCT05965310
Optimizing Suicide Prevention Strategies for Pediatric Primary Care
University of Pittsburgh
NCT06194331
Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
University of Pittsburgh
NCT06817993
A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
University of Florida
NCT07112001
The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic
Children's National Research Institute
NCT06623981
Psilocybin Therapy for Depression in Parkinson's Disease
Joshua Woolley, MD, PhD
NCT06455293
Collaborative Care for Anxiety and Depression in Epilepsy
Wake Forest University Health Sciences
NCT05559749
Transcranial Magnetic Stimulation for MCI
Medical University of South Carolina
NCT05992831
ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics
University of South Florida
NCT07360600
Inflammation and Depression in People With HIV
Emory University
NCT05849038
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
Massachusetts General Hospital
NCT07118722
Mobile CBT for Middle Aged and Older Adults
Weill Medical College of Cornell University
NCT05754151
Feasibility of a Technology-Based Intervention for Depression Referral Uptake in Cancer Survivors
Medical University of South Carolina
NCT07091968
Pharmacologic Augmentation of TMS for Depression With D-serine
Mclean Hospital
NCT06876129
Intracranial Investigation of Neural Circuity Underlying Human Mood
Baylor College of Medicine
NCT05871372
Mindfulness-Based Interventions Targeting First-Generation College Student Retention in Rural Environments
University of South Dakota
NCT06789731
Cognitive Behavioral and Faith Fellowship to Improve Thy Health
University of Wisconsin, Madison
NCT06292637
Amplitude Titration to Improve ECT Clinical Outcomes
University of New Mexi
NCT05699226
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
Lindsay Maguire, MD
NCT06085937
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
National Institute of Mental Health (NIMH)
NCT06511908
A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients
Mayo Clinic
NCT05803551
Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System
University of Illinois at Chicago
NCT06555172
Feasibility of a Prenatal Yoga Mobile App in African American Pregnant Women
San Diego State University
NCT06353113
Mood Effects of Serotonin Agonists: Depression
University of Chicago
NCT07017478
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.