Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,963 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,963 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Open enrollment, early-phase tilt
Depression has 687 registered US clinical trials, 245 of them open to new participants right now, about 36% of the total.
- 245
- recruiting participants now
- 36%
- of trials open to enrollment
- 70
- in Phase 3-4 (later-stage)
- 29
- top sponsor: Massachusetts General Hospital
Corpus placement: #5 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 4 of 14
Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest
Massachusetts General Hospital
NCT07143357
CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth
Vanderbilt University
NCT05456035
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
Baylor College of Medicine
NCT05489042
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
University of Minnesota
NCT05652153
Michigan Men's Diabetes Project III(MenDIII): Mind and Motion
University of Michigan
NCT06574035
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Boston Medical Center
NCT06812247
Study on Allopregnanolone and Depression in Women Across the Menopause Transition
Brigham and Women's Hospital
NCT06238700
Enhancing Purpose and Well-Being Through a Volunteering Experience Connecting Veterans With English Language Learners
University of Michigan
NCT06324383
Training Reward Responsiveness Through Virtual Reality
University of California, Los Angeles
NCT07219875
Potential Benefits of Parent Child Interaction Therapy (PCIT)
University of Florida
NCT06827951
Probiotic Administration for Adolescent Depression
University of California, San Francisco
NCT06898788
Mood and Thought Process Study
Butler Hospital
NCT05585775
Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II
Brigham and Women's Hospital
NCT05555875
Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
Laureate Institute for Brain Research
NCT06263660
Understanding the Role of Doulas in Supporting People With PMADs
University of Montana
NCT05763537
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
University of Illinois at Chicago
NCT06261463
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
University of California, San Diego
NCT05682677
Dopaminergic Therapy for Anhedonia - 2
Emory University
NCT06075771
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
NCT03973268
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
Washington University School of Medicine
NCT06867549
A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
Weill Medical College of Cornell University
NCT05507138
Mindfulness Engaged Neurostimulation for Depression
University of California, San Diego
NCT06399406
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
National Institute of Mental Health (NIMH)
NCT04582916
Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities
University of Michigan
NCT06721559
Impact of Depression on Thermoregulation
Penn State University
NCT06805851
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
Deepak C. D'Souza
NCT06671977
Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
Henry Ford Health System
NCT05965310
Optimizing Suicide Prevention Strategies for Pediatric Primary Care
University of Pittsburgh
NCT06194331
Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
University of Pittsburgh
NCT06817993
A Behavioral mHealth Intervention for People With HIV With Anxiety and Depression
University of Florida
NCT07112001
The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic
Children's National Research Institute
NCT06623981
Psilocybin Therapy for Depression in Parkinson's Disease
Joshua Woolley, MD, PhD
NCT06455293
Collaborative Care for Anxiety and Depression in Epilepsy
Wake Forest University Health Sciences
NCT05559749
Transcranial Magnetic Stimulation for MCI
Medical University of South Carolina
NCT05992831
ACT Together: Implementing a Web-Based Program With Brief Coaching for Parents of Children With Disabilities in Pediatric Outpatient Clinics
University of South Florida
NCT07360600
Inflammation and Depression in People With HIV
Emory University
NCT05849038
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
Massachusetts General Hospital
NCT07118722
Mobile CBT for Middle Aged and Older Adults
Weill Medical College of Cornell University
NCT05754151
Feasibility of a Technology-Based Intervention for Depression Referral Uptake in Cancer Survivors
Medical University of South Carolina
NCT07091968
Pharmacologic Augmentation of TMS for Depression With D-serine
Mclean Hospital
NCT06876129
Intracranial Investigation of Neural Circuity Underlying Human Mood
Baylor College of Medicine
NCT05871372
Mindfulness-Based Interventions Targeting First-Generation College Student Retention in Rural Environments
University of South Dakota
NCT06789731
Cognitive Behavioral and Faith Fellowship to Improve Thy Health
University of Wisconsin, Madison
NCT06292637
Amplitude Titration to Improve ECT Clinical Outcomes
University of New Mexi
NCT05699226
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
Lindsay Maguire, MD
NCT06085937
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
National Institute of Mental Health (NIMH)
NCT06511908
A Study of Ketamine Infusions to Treat Clinically-depressed ICU Patients
Mayo Clinic
NCT05803551
Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System
University of Illinois at Chicago
NCT06555172
Feasibility of a Prenatal Yoga Mobile App in African American Pregnant Women
San Diego State University
NCT06353113
Mood Effects of Serotonin Agonists: Depression
University of Chicago
NCT07017478
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Depression right now
245 recruiting of 687 indexed (36% open).
Phase mix: 70 late (III/IV) vs 111 early (I/II) (early-phase heavy).
Top sponsor: Massachusetts General Hospital (29 trials), 9 others listed. 50 shown below, recruiting first. #5 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Depression?
PlainTrial tracks 687 US clinical trials for Depression, of which 245 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.