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Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,707 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,707 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Enrollment posture brief
Registry condition depression
OPEN 245 | RECR 36% | LATE 70 | EARLY 111 | RANK #5 | SPON 29
Volume-matched condition peers
Nearest open-share peer: Pancreatic Cancer (36% recruiting · 283 trials)
Depression lists 245 open slots (36% of 687 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 3 of 14
Depression and Driving
Ganesh Babulal
NCT05446805
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
National Institute of Mental Health (NIMH)
NCT03065335
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Cedars-Sinai Medical Center
NCT05552053
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Florida International University
NCT05136703
Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders
Viome
NCT06502717
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Apimostinel + Automated Neurocognitive Training for Depression
Rebecca Price
NCT06400121
Sleep Mechanisms Of Regulating Emotions
Stanford University
NCT06373718
Investigation to Understand and Optimize Psilocybin
Charles Raison
NCT06512194
Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation
Weill Medical College of Cornell University
NCT06039930
Mechanisms of Behavioral Activation (BA)
Emory University
NCT05548244
Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care
VA Office of Research and Development
NCT04877197
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
Emory University
NCT02604277
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego
NCT06273527
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Weill Medical College of Cornell University
NCT05925322
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
New York University
NCT06262178
Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
University of California, San Diego
NCT06678880
Researching Heat and Yoga for Mood Enhancement
Massachusetts General Hospital
NCT06094088
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
Massachusetts General Hospital
NCT07082998
Stress and Pain in People Living With HIV
Yale University
NCT06784908
SilverCloud as a School-Based Intervention for Vulnerable Youth
NYU Langone Health
NCT06004414
Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life
Yale University
NCT05810259
Just-in-Time Training for Youth Mentors
University of Minnesota
NCT07129070
WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
Weill Medical College of Cornell University
NCT05183230
Developing Resilience and Anxiety Management Through the Arts
Case Western Reserve University
NCT07033052
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
National Institute of Mental Health (NIMH)
NCT05703685
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Boston University Charles River Campus
NCT05624931
Pramipexole to Enhance Social Connections
University of California, San Diego
NCT06269146
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
Portland State University
NCT06019377
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
University of North Carolina, Chapel Hill
NCT05282277
Identifying and Treating Depression in the Orthopaedic Trauma Population
Wake Forest University Health Sciences
NCT05976347
Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
Texas Tech University
NCT06055322
Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners
Massachusetts General Hospital
NCT07220486
Psilocybin-Assisted Therapy for Intergenerational Trauma
Rachel Yehuda
NCT06899165
Randomized Controlled Trial of a Behavioral Training App
New York University
NCT06447909
Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)
Northwestern University
NCT05942469
Psilocybin rTMS for Treatment Resistant Depression
University of Texas at Austin
NCT06132178
Amplification of Positivity for Alcohol Use
Laureate Institute for Brain Research
NCT06030154
Geolocation Positional System (GPS) Experience
University of Miami
NCT05991713
Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)
NYU Langone Health
NCT06455527
Virtual Patient Groups for Sarcoidosis Associated Fatigue
The Cleveland Clinic
NCT07073963
Personalized Mobile Cognitive Behavioral Therapy Application
Weill Medical College of Cornell University
NCT05699525
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Weill Medical College of Cornell University
NCT05081596
Concurrent TMS-fMRI
Jing Jiang
NCT06633913
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
University of Wisconsin, Madison
NCT06162624
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
University of Pittsburgh
NCT06963463
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Massachusetts General Hospital
NCT06316804
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Texas Tech University Health Sciences Center
NCT06903819
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
University of Cincinnati
NCT04245748
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression page
687 registered trials, 245 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 245 Depression trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Depression trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression condition card totals 687 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.