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Depression: early-phase trial registry
245 of 687 indexed Depression trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #5 of 28,963 conditions by registered trial count.
687 US clinical trials · 245 currently recruiting · #5 of 28,963 conditions by registered trial count
Depression: 687 US clinical trials tracked, 245 recruiting.
Depression is the subject of 687 registered US clinical trials on ClinicalTrials.gov, 245 of them currently open to new participants. 70 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 29 of these trials.
Open enrollment, early-phase tilt
Depression has 687 registered US clinical trials, 245 of them open to new participants right now, about 36% of the total.
- 245
- recruiting participants now
- 36%
- of trials open to enrollment
- 70
- in Phase 3-4 (later-stage)
- 29
- top sponsor: Massachusetts General Hospital
Corpus placement: #5 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Depression on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Depression recruits in line with its size-band peers.
245 of 687 indexed trials (35.7%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depression trials is spread across many organizations.
Massachusetts General Hospital accounts for 29 of 687 trials (4.2%). 231 distinct sponsors appear on at least one study for this condition label.
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Typical Depression enrolment sits around 100 participants.
Median target enrolment is 100 among the 680 trials that report a genuine target (sentinel values excluded). 331 of those (48.7%) plan for fewer than 100 participants.
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Depression research is mostly interventional.
618 interventional and 69 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
687 total, page 3 of 14
Depression and Driving
Ganesh Babulal
NCT05446805
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
National Institute of Mental Health (NIMH)
NCT03065335
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Cedars-Sinai Medical Center
NCT05552053
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
University of Pittsburgh
NCT05658796
Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Florida International University
NCT05136703
Viome Precision Nutritional Programs to Improve Clinical Outcomes for Mental Health Disorders
Viome
NCT06502717
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
San Francisco Veterans Affairs Medical Center
NCT06080646
Apimostinel + Automated Neurocognitive Training for Depression
Rebecca Price
NCT06400121
Sleep Mechanisms Of Regulating Emotions
Stanford University
NCT06373718
Investigation to Understand and Optimize Psilocybin
Charles Raison
NCT06512194
Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation
Weill Medical College of Cornell University
NCT06039930
Mechanisms of Behavioral Activation (BA)
Emory University
NCT05548244
Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care
VA Office of Research and Development
NCT04877197
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
Emory University
NCT02604277
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
University of California, San Diego
NCT06273527
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Weill Medical College of Cornell University
NCT05925322
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
New York University
NCT06262178
Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
University of California, San Diego
NCT06678880
Researching Heat and Yoga for Mood Enhancement
Massachusetts General Hospital
NCT06094088
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
Massachusetts General Hospital
NCT07082998
Stress and Pain in People Living With HIV
Yale University
NCT06784908
SilverCloud as a School-Based Intervention for Vulnerable Youth
NYU Langone Health
NCT06004414
Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life
Yale University
NCT05810259
Just-in-Time Training for Youth Mentors
University of Minnesota
NCT07129070
WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
Weill Medical College of Cornell University
NCT05183230
Developing Resilience and Anxiety Management Through the Arts
Case Western Reserve University
NCT07033052
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
National Institute of Mental Health (NIMH)
NCT05703685
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Boston University Charles River Campus
NCT05624931
Pramipexole to Enhance Social Connections
University of California, San Diego
NCT06269146
Intervention to Enhance Coping and Help-seeking Among Youth in Foster Care
Portland State University
NCT06019377
Examining the Effects of Estradiol on Neural and Molecular Response to Reward
University of North Carolina, Chapel Hill
NCT05282277
Identifying and Treating Depression in the Orthopaedic Trauma Population
Wake Forest University Health Sciences
NCT05976347
Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
Texas Tech University
NCT06055322
Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners
Massachusetts General Hospital
NCT07220486
Psilocybin-Assisted Therapy for Intergenerational Trauma
Rachel Yehuda
NCT06899165
Randomized Controlled Trial of a Behavioral Training App
New York University
NCT06447909
Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)
Northwestern University
NCT05942469
Psilocybin rTMS for Treatment Resistant Depression
University of Texas at Austin
NCT06132178
Amplification of Positivity for Alcohol Use
Laureate Institute for Brain Research
NCT06030154
Geolocation Positional System (GPS) Experience
University of Miami
NCT05991713
Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)
NYU Langone Health
NCT06455527
Virtual Patient Groups for Sarcoidosis Associated Fatigue
The Cleveland Clinic
NCT07073963
Personalized Mobile Cognitive Behavioral Therapy Application
Weill Medical College of Cornell University
NCT05699525
A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD
Weill Medical College of Cornell University
NCT05081596
Concurrent TMS-fMRI
Jing Jiang
NCT06633913
Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons
University of Wisconsin, Madison
NCT06162624
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
University of Pittsburgh
NCT06963463
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Massachusetts General Hospital
NCT06316804
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Texas Tech University Health Sciences Center
NCT06903819
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
University of Cincinnati
NCT04245748
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 70 |
| Phase 3 | 29 |
| Phase 4 | 41 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Depression right now
245 recruiting of 687 indexed (36% open).
Phase mix: 70 late (III/IV) vs 111 early (I/II) (early-phase heavy).
Top sponsor: Massachusetts General Hospital (29 trials), 9 others listed. 50 shown below, recruiting first. #5 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Depression?
PlainTrial tracks 687 US clinical trials for Depression, of which 245 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depression?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.