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NCT05652153 · ClinicalTrials.gov registry record · NA
Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior
A NA study of Depression and Suicidal Ideation, sponsored by University of Minnesota.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT05652153: Recruiting NA study of Depression and Suicidal Ideation, sponsored by University of Minnesota.
NCT05652153 is a NA study of Depression and Suicidal Ideation that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 80 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05652153, a NA study of Depression and Suicidal Ideation, is actively recruiting participants, sponsored by University of Minnesota.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure negative urgency and brain signals in adolescents aged 13-21 years with depression and suicidal thoughts and behaviors. The main questions it aims to answer are: * Whether a type of brain signaling called cortical inhibition is related to negative urgency * Whether depressed adolescents with suicidal behavior have more problems with cortical inhibition than depressed adolescents with suicidal thoughts only * Whether the relationship between negative urgency and cortical inhibition changes over time Adolescents who participate in the study will complete the following activities at the time they join the study, as well as 6 months and 12 months later: * Interviews with researchers and questionnaires to learn about their thoughts, emotions, and symptoms * A questionnaire about impulsive behaviors and negative urgency * Computerized games that measure brain functions * An MRI scan of the brain * Transcranial magnetic stimulation with electroencephalography (TMS-EEG), a way to measure how brain cells communicate (cortical inhibition) using a magnet placed outside of the head and recording brain signals
Primary Outcome
LICI is a measure of cortical inhibitory physiology that is obtained by recording event-related potentials on electroencephalography (EEG) when applying paired magnetic pulses with transcranial magnetic stimulation (TMS).
Conditions Studied
Interventions
- OTHER Single-/paired-pulse transcranial magnetic stimulation
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2024-05-25 |
| Est. Completion | 2028-01 |
| Phase | NA |
What NCT05652153 shows while recruiting
NCT05652153 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (90% lower).
The record links to 5 conditions, with Depression appearing as the primary indexed condition, and to 1 intervention - of which Single-/paired-pulse transcranial magnetic stimulation is the first listed.
NCT05652153 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT05652153 about?
NCT05652153 is a clinical study titled "Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior". The goal of this study is to understand why some people act more impulsively when feeling negative emotions, which is called negative urgency. The researchers hope to understand how negative urgency relates to the way networks of brain cells communicate with one another. The researchers will measure...
What is the current status of trial NCT05652153?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-05-25. Estimated completion is 2028-01.
What conditions does trial NCT05652153 study?
This clinical trial studies the following conditions: Depression, Suicidal Ideation, Suicidal Behavior, Negative Urgency, Cortical Inhibition.
What interventions are being tested in trial NCT05652153?
The interventions under investigation include: Single-/paired-pulse transcranial magnetic stimulation (OTHER).
Who is sponsoring clinical trial NCT05652153?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05652153 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05652153's enrollment target sits among peer trials
80 373rd of 679 higher than 299 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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