Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05682677 · ClinicalTrials.gov registry record · NA
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
A NA study of Depression and Mild Traumatic Brain Injury, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- NA
- Development phase
- 72
- Enrollment target
- 1
- Study location
NCT05682677: Recruiting NA study of Depression and Mild Traumatic Brain Injury, sponsored by University of California, San Diego.
NCT05682677 is a NA study of Depression and Mild Traumatic Brain Injury that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 72 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05682677, a NA study of Depression and Mild Traumatic Brain Injury, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- NA
- Development phase
- 72 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to see if PACT+iTBS is associated with more depression improvement.
Conditions Studied
Interventions
- DEVICE iTBS
- DEVICE sham iTBS
- BEHAVIORAL Personalized, Augmented Cognitive Training (PACT)
Study Locations (1)
California
- UCSD - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2023-09-19 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT05682677 shows while recruiting
NCT05682677 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (91% lower).
The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 3 interventions - of which iTBS is the first listed.
NCT05682677 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05682677 about?
NCT05682677 is a clinical study titled "Combined Neuromodulation and Cognitive Training for Post-mTBI Depression". The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive P...
What is the current status of trial NCT05682677?
This trial is currently recruiting. It is a NA study. The enrollment target is 72 participants. The study started on 2023-09-19. Estimated completion is 2026-06-30.
What conditions does trial NCT05682677 study?
This clinical trial studies the following conditions: Depression, Mild Traumatic Brain Injury, Concussion, Brain.
What interventions are being tested in trial NCT05682677?
The interventions under investigation include: iTBS (DEVICE), sham iTBS (DEVICE), Personalized, Augmented Cognitive Training (PACT) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05682677?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05682677 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05682677's enrollment target sits among peer trials
72 402nd of 679 higher than 277 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Reaching Out to Distressed Medical Residents, Fellows and Faculty
RECRUITING · NA
-
IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
RECRUITING · NA
-
Cold and Heat Investigation to Lower Levels of Depression
RECRUITING · NA
-
Dosing rTMS for Depression Post-SCI
RECRUITING · NA
-
Exploring Virtual Reality Adventure Training Exergaming
RECRUITING · NA
-
Brief Interventions for Coping with Distress
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02359253 · 72 participants · NA
Robot Aided Rehabilitation - Intervention
- NCT02962661 · 72 participants · Phase 1
Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines
- NCT03113643 · 72 participants · Phase 1
SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
- NCT03187535 · 72 participants · NA
Effect of TEAS on PONV After Spinal Surgery
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT06358040 · started 2026-10 · NA
Opioid Dispenser for Microdiscectomy/Laminectomy