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NCT07219875 · ClinicalTrials.gov registry record · Phase 2
Training Reward Responsiveness Through Virtual Reality
A Phase 2 study of Depression and Positive Affect, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT07219875: Recruiting Phase 2 study of Depression and Positive Affect, sponsored by University of California, Los Angeles.
NCT07219875 is a Phase 2 study of Depression and Positive Affect that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 80 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07219875, a Phase 2 study of Depression and Positive Affect, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either enhanced Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys. The total length of participation is around 3 months.
Primary Outcome
Change in reported anhedonia (score range: 14-70), with higher scores indicating greater anhedonic symptom severity
Conditions Studied
Interventions
- BEHAVIORAL Enhanced Virtual Reality-Reward Training (eVR-RT)
- BEHAVIORAL Virtual Reality-Memory Training (VR-MT)
Study Locations (1)
California
- University of California, Los Angeles - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-07-08 |
| Est. Completion | 2027-06 |
| Phase | Phase 2 |
What NCT07219875 shows while recruiting
NCT07219875 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Enhanced Virtual Reality-Reward Training (eVR-RT) is the first listed.
NCT07219875 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07219875 about?
NCT07219875 is a clinical study titled "Training Reward Responsiveness Through Virtual Reality". The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing ...
What is the current status of trial NCT07219875?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2025-07-08. Estimated completion is 2027-06.
What conditions does trial NCT07219875 study?
This clinical trial studies the following conditions: Depression, Positive Affect.
What interventions are being tested in trial NCT07219875?
The interventions under investigation include: Enhanced Virtual Reality-Reward Training (eVR-RT) (BEHAVIORAL), Virtual Reality-Memory Training (VR-MT) (BEHAVIORAL).
Who is sponsoring clinical trial NCT07219875?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07219875 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07219875's enrollment target sits among peer trials
80 373rd of 679 higher than 299 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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