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NCT07017478 · ClinicalTrials.gov registry record · Early Phase 1

Mood Effects of Serotonin Agonists: Depression

A Early Phase 1 study of Depression and Major Depressive Disorder, sponsored by University of Chicago.

Recruiting
Registry status
Early Phase 1
Development phase
48
Enrollment target
1
Study location

NCT07017478 is a Early Phase 1 study of Depression and Major Depressive Disorder that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 48 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07017478, a Early Phase 1 study of Depression and Major Depressive Disorder, is actively recruiting participants, sponsored by University of Chicago.

RECRUITING
Registry status
Early Phase 1
Development phase
48 participants
Enrollment target
1
Study location

Study Summary

This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

Conditions Studied

Depression Major Depressive Disorder LSD

Interventions

  • DRUG Placebo
  • DRUG LSD

Study Locations (1)

Illinois

  • University of Chicago - Chicago

Trial Details

FieldValue
Enrollment Target 48 participants
Start Date 2025-06-09
Est. Completion 2026-06-01
Phase Early Phase 1

Sponsor

University of Chicago

796 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07017478

The ClinicalTrials.gov registry entry for NCT07017478 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 786-participant average among 679 other Depression trials with a reported enrollment target (94% lower). The listed sponsor is University of Chicago, which has 796 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Depression appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT07017478 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.

Frequently Asked Questions

What is clinical trial NCT07017478 about?

NCT07017478 is a clinical study titled "Mood Effects of Serotonin Agonists: Depression". This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

What is the current status of trial NCT07017478?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 48 participants. The study started on 2025-06-09. Estimated completion is 2026-06-01.

What conditions does trial NCT07017478 study?

This clinical trial studies the following conditions: Depression, Major Depressive Disorder, LSD.

What interventions are being tested in trial NCT07017478?

The interventions under investigation include: Placebo (DRUG), LSD (DRUG).

Who is sponsoring clinical trial NCT07017478?

This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07017478 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.